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JP2018531951A |
Described herein are sustained release formulations of polymer-coated local anesthetics and their use for relieving or managing pain, including postoperative pain. [Selection diagram] Fig. 6
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JP2018531065A |
The multi-chamber syringe unit (10) has a side wall (210), a distal end (230), a proximal end (220) opposite the distal end (230), and a distal end (220). An interior defined by a side wall (210) between the 230) and the proximal end sid...
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JP2018530599A |
In general, the present invention provides kits, devices and methods for determining the ineffectiveness of an anesthetic (eg, lidocaine) using a topical method without injection. The method typically uses the placement of aliquots of tw...
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JP6392883B2 |
Provided are a propofol-containing oil-in-water emulsion composition having high stability even in a case in which the emulsion composition is charged into a plastic container; and a method for producing the same. Provided is a propofol-...
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JP2018138552A |
To provide cochleate formulations containing biologically relevant molecules.A cochleate composition comprises a population of cochleates, where the cochleates comprise: a) one or more negatively charged first lipids; b) a cation, where ...
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JP6378702B2 |
The present invention relates to a chewable formulation for delivering a nutritional or pharmaceutically active agent to an animal target. The chewable formulation comprises a nutritional ingredient or an effective amount of a pharmaceut...
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JP2018127481A |
To provide bile acid 11-hydroxyl derivatives and amino acid conjugates thereof, as farnesoid X receptor modulators.The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt, solvate or amino acid conj...
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JP2018127466A |
To provide pharmaceutical compositions comprising compounds for treating pain and methods for treating pain.The present invention relates to ketamine derivatives of the formula (I), pharmaceutical compositions comprising them, and method...
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JP6369551B2 |
Systems, devices, and methods for delivering therapeutic particles are disclosed. In one variation, a device for delivering particles includes a gas supply configured for supplying gas under pressure, a particle cassette comprising the p...
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JP6363115B2 |
What is disclosed is a semi-solid controlled release pharmaceutical composition containing biocompatible and bioerodible semi-solid lipid matrix incorporating local anesthetics agents to form a semi-solid solution, a method of using the ...
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JP2018519328A |
Equation (I)The compounds according to the invention and pharmaceutically acceptable salts thereof and their pharmaceutical compositions are provided; in the formula, R.1, R2, And R5Is as defined herein. The compounds of the present inve...
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JP6359586B2 |
Disclosed are: an ophthalmic composition according to a non-conventional novel preparation, which has histamine release inhibitory action; and an ophthalmic composition for a silicone hydrogel contact lens, which is capable of suppressin...
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JP2018517751A |
The present invention relates to a method of treating a patient in need of a treatment method using fentanyl or a salt thereof, which is essentially derived from fentanyl or a salt thereof as the only active ingredient, sugar or sugar al...
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JP2018516910A |
Processes that limit the effects of surgery on nerves, including the step of applying therapeutic material to nerves during surgery, are disclosed in several forms. In some embodiments, a formulation for reducing nerve trauma, with activ...
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JP6347784B2 |
The invention relates to an aqueous composition comprising a quaternary ammonium blocking agent and a polyhydroxy acid based excipient, and a method for producing said composition. In particular the neuromuscular blocking agent may be a ...
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JP6349330B2 |
Methods for providing post-operative pain control or relief, without a medically significant degree of numbness, to a patient are disclosed. Methods include, for example, administering bicarbonate and a calcium salt to an area of a patie...
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JP6334678B2 |
A medical dressing comprising an absorbent adhesive layer having a pharmaceutically active agent incorporated, the non-skin-facing surface being provided with a backing layer and the skin facing surface being interrupted by a pattern of ...
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JP6313420B2 |
Since each of the site I sodium channel blockers have a unique activity and cannot be used to extrapolate the same effective dosage for another site I sodium channel blocker, studies were conducted to identify dosages of neosaxitoxin ("N...
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JP6313286B2 |
The present invention provides novel compositions comprising benzodiazepine derivatives according to formula (I). Also provided are compositions comprising at least one hygroscopic excipient, in particular lactose and/or dextran.
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JP6312146B2 |
The present invention provides methods for reducing pain in a subject in need of such pain reduction by delivering, e.g., intrathecally or epidurally, a volatile anesthetic such as a halogenated ether compound in an amount effective to r...
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JP6309957B2 |
The present invention relates to ketamine derivatives of the formula (I), pharmaceutical compositions comprising them, and methods for treating pain comprising administering them, and their use in the manufacture of medicaments for treat...
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JP2018507087A |
The infusion device: has an internal chamber sized and configured to hold at least one flange of the syringe and a plunger, with a housing; with a trigger held by the housing; communicates with the trigger and has an upper end. Includes ...
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JP2018506603A |
Hyaluronic acid products contain crosslinked hyaluronic acid and one or more cyclodextrin molecules. Hyaluronic acid is cross-linked by ether bonds, and one or more cyclodextrin molecules are grafted to cross-linked hyaluronic acid by am...
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JP6290521B1 |
To enable continuous drug permeation for a long period of time without depleting the drug at an appropriate stage when the drug is applied in an appropriate range, and to increase the amount of exfoliation of the keratin when the patch i...
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JP6290081B2 |
The present invention concerns a solid, palatable composition and its preparation process which, relative to the total weight of the composition, comprises:5 to 30%, preferably 8 to 20% by weight of at least one fat chosen from among a l...
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JP2018504420A |
The present disclosure provides an injectable ganaxolone formulation containing ganaxolone, sulfobutyl ether-β-cyclodextrin, and water. The injectable ganaxolone preparation optionally contains a surfactant and a pH regulator. Ganaxolon...
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JP2018002746A |
To provide a formation for the application to the body surface.The invention relates to a formation with a certain shape, applicable to the body surface comprising a skeletogenic agent consisting of a soluble alginate with low viscosity;...
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JP2017538777A |
The present invention relates to a tetracaine-based anesthetic preparation and a method for using the same. The present invention also uses tetrakine-based dental anesthesia formulations, as well as maxillary dental arches including the ...
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JP2017226691A |
To provide novel formulations of volatile anesthetics and methods of use for treating an inflammation or wound.In a composition, a component of an emulsion comprising a lipid, such as soybean oil or olive oil, is a solution comprising: a...
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JP6254681B2 |
The present invention relates to a phenol derivative and the preparation method and use in medicine thereof, and particular to a phenol derivative represented by general formula (A) or a stereoisomer, a solvate, a metabolite, a prodrug, ...
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JP2017537127A |
Lines that can be molded in the form of large and / or heavy film strips or sheets during production and subsequently cut into uniform dosage units, each dosage unit being uniform in content and distributed therein. A film product that h...
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JP2017218450A |
To provide methods and formulations for regional delivery and for reducing a pain in a subject in need of pain reduction.The present invention provides use of volatile anesthetics, methods of administering the same, and formulations suit...
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JP2017215332A |
To provide compositions and methods of using the compositions for diagnosis and treatment of immune-related diseases.The invention provides a method of determining whether a test immune cell is an activated or normal Treg, memory T cell,...
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JP2017535612A |
Sublingual administration of riluzole is disclosed. In particular, methods of treating neuropsychiatric disorders or neuropsychiatric symptoms by administering a sublingual preparation of riluzole are provided. In addition, a method of a...
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JP2017534656A |
The present invention provides a method for treating extremity licking granulomas in canines using capsaicinoids such as capsaicin. The present invention also uses capsaicinoids such as capsaicin to form C and A delta fibers, respectivel...
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JP6236077B2 |
We describe ultra-short, short, and intermediate duration neuromuscular blocking compounds, reversible by cysteine or similar compounds, that are bisquaternary diesters of chlorofumaric, fumaric, or maleic acids where the quaternary grou...
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JP2017531011A |
Provide a method of treatment useful in inducing or maintaining anesthesia in a subject. The method comprises administering the compounds disclosed herein to a subject in need of anesthesia. Also provided are novel compounds having an an...
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JP6215354B2 |
Disclosed are aqueous pharmaceutical compositions which provide sustained released delivery of corticosteroid compounds. The pharmaceutical composition comprises an insoluble corticosteroid; a soluble corticosteroid; and at least one vis...
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JP6209749B2 |
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JP2017528527A |
Described herein are injectable drug-filled microparticles, a pharmaceutical composition of the microparticles and a method of using the pharmaceutical composition in a body compartment or for systemic administration.
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JP6202570B2 |
To provide a solid anesthetic for fishes by utilizing carbon dioxide derived from sodium hydrogen carbonate, in which whether an anesthetic effect of the solid anesthetic for fishes has been lost by the anesthetic absorbing moisture in t...
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JP6200648B2 |
The present invention relates to, among other things, methods for treating trigeminal cephalgias such as migraine and migraine like headaches and other cerbrovascular conditions associated with pain and or inflammation. When non-steroida...
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JP2017159298A |
To provide an apparatus for formulating a pharmaceutical formulation containing large-diameter synthetic membrane vesicles such as multivesicular liposomes.This invention is generally related to a field of pharmaceutical science. In part...
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JP6196986B2 |
Provided herein are compounds according to formula (I): Provided herein is also a pharmaceutical composition comprising a compound according to formula (I) and a pharmaceutically acceptable carrier, and a method for providing anesthesia ...
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JP6189313B2 |
The invention relates to substituted pyrazolyl-based carboxamide and urea derivatives of formula (Q) as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the trea...
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JP6186494B2 |
The present disclosure provides substituted pyridyl-, pyrimidinyl-, pyrazinyl-, pyridazinyl-, and triazinyl-based carboxamides of FormulaI-A:and the pharmaceutically acceptable salts and solvates thereof, wherein Z, HET, R10, and E are d...
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JP2017523175A |
Dimethylaniline long chain compounds, and their preparation, self-assembling structure and uses. The compound is an n-diethylaminoacetyl-2,6-dimethylaniline compound having a structure represented by the following formula (1), which can ...
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JP6174690B2 |
The invention relates to a method of preparing a composition, the composition comprising a crosslinked first polymer, optionally a second polymer, which may be crosslinked or non-crosslinked, and water, wherein the first and the second p...
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JP6168420B2 |
An object of the present invention is to provide a medicine for general anesthesia which can prevent and/or alleviate an anesthetic-induced neurological deficit in the brain (preferably in the developing brain). The present invention rel...
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JP6161744B2 |
A method for treating subjects experiencing neuropathic pain is provided. The method involves the application of a solid-forming local anesthetic formulation to a skin surface of the subject experiencing the neuropathic pain and then mai...
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