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WO/2024/059952A1 |
This application relates to drug delivery systems comprising thin films configured for administration to the ocular mucosa. In some embodiments, a drug delivery system comprises a multi-layer thin film having a first bioadhesive layer fo...
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WO/2024/038870A1 |
Provided are: a compound having excellent abrasion resistance and slip resistance; a composition; a surface treatment agent; a coating liquid; an article; and a method for producing said article. The compound according to the present d...
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WO/2024/016438A1 |
The present invention relates to a preparation method for hexafluorobutadiene. The method comprises: 1) performing temperature raising and pressure increase reactions on chlorotrifluoroethylene, and then performing a thermal polymerizati...
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WO/2023/208151A1 |
The present disclosure provides a compound which has an inhibitory effect on USP, a pharmaceutically acceptable salt, a stereoisomer, a solvate or a prodrug thereof, as shown in formula (I), the definition of each group in the formula be...
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WO/2023/189217A1 |
This method for producing a fluorine-containing cyclic olefin composition includes: a mixing step for mixing an acid catalyst and one or more types of hydroxyl group-containing compounds (C) which are selected from the group consisting o...
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WO/2023/162998A1 |
The purpose of the present invention is to provide an iodo compound–containing liquid composition that has better photostability than conventional iodo compound–containing liquid compositions. According to the present invention, a ...
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WO/2023/047104A9 |
The invention relates to a process for producing a compound comprising an 18F-difluoromethyl group or a compound comprising an 18F-difluoromethylene group, which process comprises contacting a compound comprising a nucleophilic group wit...
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WO/2023/037934A1 |
A production method for an encapsulation of a bicycloalkane compound, the method comprising mixing a bicycloalkane compound and a cyclodextrin compound in a mixed solvent of water and an organic solvent.
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WO/2023/037933A1 |
A method for producing a halogenobicyclo[1.1.1]pentane comprising: a step (a) in which [1.1.1]propellane is obtained by causing a reaction between 1,1-dibromo-2,2-bis(chloromethyl)cyclopropane and an organometallic reagent in a solvent c...
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WO/2023/286753A1 |
The present disclosure addresses the problem of producing an alkene having a double bond in position 2 and having four or more carbons by means of isomerization. This method for producing an alkene having a double bond at position 2 and ...
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WO/2023/282241A1 |
This method is for producing a composition containing octafluorocyclobutane and octafluorobutane, and comprises (1A) a step for causing a reaction between a raw material composition and a gas containing hydrogen in the presence of a hydr...
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WO/2022/249788A1 |
The purpose of the present invention is to provide a method for producing cycloalkyl bromide without using heavy metals, etc. The present invention provides a method for producing a compound represented by formula (2) [in the formula, ...
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WO/2022/229377A1 |
The present invention relates to new amphiphilic perfluorinated compounds and their use as a detergent for extracting membrane-proteins or synthesizing membrane-proteins in acellular system. It also relates to a method for extracting a m...
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WO/2022/220231A1 |
The purpose of the present invention is to provide a novel technique which can be employed in the production of a fluorinated substance using 2,6-dimethyl-4-t-butyl-trifluorosulfanylbenzene, whereby it becomes possible to remove an SOF t...
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WO/2022/147465A1 |
The present invention provides compounds, compositions thereof, and methods of using the same.
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WO/2022/124273A1 |
According to the present invention, a fullerene derivative having a partial structure represented by general formula (1) is used. (In general formula (1), C*'s are carbon atoms which form a fullerene skeleton and are adjacent to each oth...
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WO/2022/100711A1 |
An environmentally-friendly and efficient novel synthetic method for 1-acetyl-1-chlorocyclopropane. Under the promotion effect of a ionic liquid, a raw material 3,5-dichloro-2-pentanone is subjected to a ring-closure reaction under alkal...
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WO/2022/059301A1 |
Provided is an octafluorocyclobutane purification method by which mixed-in fluorocarbons can be removed to obtain high purity octafluorocyclobutane. This octafluorocyclobutane purification method comprises: a decomposition step in which ...
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WO/2021/254417A1 |
Provided are a bicyclic compound as represented by formula (I), a composition and a preparation comprising the compound, a method for using the compound, and a method for preparing the compound.
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WO/2021/178857A1 |
Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for the inhibition of Signal Transducer and Activator of Transcription 5a and 5b (STAT5). Furthermore, the subject compounds and comp...
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WO/2021/168446A1 |
The present disclosure is directed to adenine analogs, methods of making adenine analogs, and methods of treating disorders associated with PINK1 kinase activity including, but not limited to, neurodegenerative diseases, mitochondrial di...
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WO/2021/167987A1 |
The present application is related to an improved process for synthesising 1 -(difluoromethyl)-3-iodobicyclo[1.1.1 ]pentane from difluoromethyl iodide and [1.1.1]propellane. Difluoromethyl iodide is made by reacting an iodide salt with c...
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WO/2021/029420A1 |
A method for producing at least one compound selected from the group consisting of 1,1,2-trifluoroethylene, hexafluoro-1,3-butadiene, and 1,2-dichlorohexafluorocyclobutane, the method including a step in which 1,1,2-trifluoro-2-chloroeth...
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WO/2020/230725A1 |
The present invention addresses the problem of providing a novel method for producing a fluorinated iodinated organic compound. This problem can be solved by a method for producing a fluorinated iodinated organic compound, the method inc...
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WO/2020/195454A1 |
The present invention provides a method for dehydrating an organic solvent, while suppressing an increase in the number of fine particles. A method for dehydrating an organic solvent according to the present invention comprises: a step (...
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WO/2020/195252A1 |
In the present invention, a halogenated cycloalkane compound is obtained at a high conversion rate by reacting a halogenated cycloalkene compound and a hydrogen-containing gas in the presence of a hydrogenated catalyst or a catalyst havi...
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WO/2020/145088A1 |
The purpose of the present disclosure is to produce a cyclobutane containing a fluorine atom with high selectivity. A method for producing a cyclobutane represented by general formula (1) (wherein X1, X2, X3, X4, X5 and X6 may be the s...
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WO/2020/137825A1 |
The purpose of the present disclosure is to produce a cyclobutene which contains a halogen atom with high selectivity. A method for producing a cyclobutene represented by general formula (1) (wherein X1, X2, X3 and X4 may be the same o...
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WO/2020/137824A1 |
The purpose of the present invention is to produce cyclobutene containing a halogen atom with a high conversion ratio (yield) and high selectivity. This method, for producing the cyclobutene represented in general formula (1) (in the f...
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WO/2020/075728A1 |
Through this method in which: a catalyst is included which is any of (a) a catalyst including a prescribed element, (b) a catalyst including at least two prescribed elements, (c) a prescribed fluorinated metal oxide having a pore volume ...
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WO/2020/075729A1 |
A perfluorocycloalkene compound represented by formula (1) [in the formula, R1-R4 are the same or different and represent a fluorine atom or a perfluoroalkyl group] is obtained at a high yield and high selectivity as well as a high react...
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WO/2020/051855A1 |
Disclosed are a reduction method and reduction product of an alkenyl active methylene compound. The reduction reaction comprises the following steps: taking an alkenyl active methylene compound as a substrate, a metal hydride as a reduci...
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WO/2020/047985A1 |
The present invention belongs to the technical field of chemical preparation, and particularly relates to a difluoromethylation agent, preparation therefor and use thereof. Aiming at the key problem of poor stability of current electroph...
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WO/2020/044825A1 |
A method for solvent purification which comprises distilling a solvent with distillation equipment 10 including a distillation vessel 1, thereby obtaining the solvent that has been purified. Members constituting the distillation equipmen...
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WO/2020/039297A1 |
The present invention relates to the novel compounds of Formula I, and salts thereof and use of said compounds as intermediates for the preparation of (E)-2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxoprop-1-
en-1-yl)phenoxy)-2-methyl...
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WO/2020/037209A1 |
A series of benzosuberene analogues demonstrate effective inhibition of tubulin polymerization, cytotoxicity against human cancer cell lines, and vascular dismption in tumors.
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WO/2020/031732A1 |
Provided are a refining method for reducing microparticles included in a fluorine-based-solvent-containing article, and a refined fluorine-based-solvent-containing article in which microparticles are reduced. This method for refining a f...
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WO/2019/127921A1 |
The present invention relates to a compound for a polypeptide liquid-phase synthesis carrier, a preparation method therefor and use thereof. Specifically, disclosed is a cyclic ketone compound as a polypeptide liquid-phase carrier, havin...
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WO/2019/018495A1 |
A polystyrene-g-(polyisobutylene-b-polystyrene) is taught. The polystyrene-g-(polyisobutylene-b-polystyrene) is synthesized by first providing a polystyrene backbone. Once the polystyrene backbone is provided, the polystyrene backbone is...
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WO/2018/235567A1 |
This method for producing octafluorocyclopentene involves bringing 1-chloroheptafluorocyclopentene into contact with an alkali metal fluoride. Said production method includes a fluorination step in which a suspension obtained by suspendi...
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WO/2018/235566A1 |
This method for producing octafluorocyclopentene involves bringing 1-chloroheptafluorocyclopentene into contact with an alkali metal fluoride. Said production method includes: a raw material heating step in which 1-chloroheptafluorocyclo...
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WO/2018/201000A1 |
Compounds and methods are provided for one-step functionalization of disulfide bonds in proteins.
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WO/2018/177661A1 |
The invention relates to a new type of process for synthesizing fluorinated cyclic aliphatic compounds from the analogous aromatic compounds by means of hydrogenation with an Rh-carbene catalyst system.
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WO/2018/133473A1 |
Provided in the present invention is a direct oxidation method for a saturated carbon hydrogen bond in an organic compound, comprising: under conditions of visible light irradiation, reacting the organic compound with an oxidising reagen...
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WO/2018/078068A1 |
The invention relates to a process for the preparation of substituted 2-halo-benzindene compounds. The invention further relates to a process for the preparation of a metallocene complex from such substituted 2-halo-benzindene compounds....
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WO/2018/037999A1 |
The purpose of the present invention is to provide an industrially convenient and inexpensive method for efficiently removing butenes from crude monofluorobutane that includes butenes without substantially causing the monofluorobutane to...
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WO/2017/181517A1 |
The present invention relates to a manufacturing method of 1,2-dichlorohexafluorocyclopentene. The manufacturing method of 1,2-dichlorohexafluorocyclopentene comprises the following reaction steps: (1) using cyclopentadiene as a starting...
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WO/2017/181566A1 |
Disclosed is a manufacturing method of 1,2-dichlorohexafluorocyclopentene. The first reaction uses dicyclopendatiene as a starting material and nitrogen gas or another inert gas as a diluting agent in a gas-phase thermal cracking reactio...
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WO/2017/176392A1 |
The invention provides a new convergent approach for the synthesis of 2'-fluoro-6'- methylene-carbocyclic adenosine (FMCA) and 2'-fluoro-6'-methylene-carbocyclic guanosine (FMCG) from a readily available starting material in eight steps....
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WO/2017/127642A1 |
In various embodiments, the present invention is directed to new low cost initiator compositions for use with the production of well-defined telechelic PIBs (by LC+P of isobutylene). In various other embodiments, the present invention is...
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