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WO/2011/079188A2 |
Clickable polyunsaturated fatty acid analogs, methods of using these analogs and kits comprising these analogs.
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WO/2011/074643A1 |
Disclosed is an external preparation for skin, which is suitable for the prevention or amelioration of pigmentation. Specifically disclosed are: a prophylactic or ameliorating agent for pigmentation, comprising a compound represented by ...
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WO/2011/070028A1 |
Whilst methodologies for the Kinetic Resolution of alcohols are well established, no analogous direct methods exist for the highly selective, direct catalytic Kinetic Resolution of thiols (i.e., R-SH). The present invention relates to a ...
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WO/2011/069994A1 |
The invention relates to a method for producing 2,2-difluoroethylamine of formula (I) and salts thereof, such as sulfates, hydrochlorides, or acetates, starting from difluoroacetone nitrile.
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WO/2011/067266A1 |
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing...
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WO/2011/067278A1 |
The invention relates to a method for producing formamides by converting aromatic amines and a formic acid ester in the presence of a catalyst, the method being characterized in that the catalyst is a phosphoric acid or a Lewis acid meta...
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WO/2011/067174A1 |
Provided herein are compounds of the formula (I), as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing...
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WO/2011/066156A1 |
A method for preparing highly fluorinated carboxylic acids and theirs salts and the precursors thereof comprising subjecting a highly fluorinated olefin of the general formula (I) : Rf(O)n-(CF2)m-CF=CF2 to a derivative of formic acid acc...
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WO/2011/066414A1 |
The present invention provides arachidonic acid (AA) analogs and compositions containing those analogs as active agents for use in analgesic treatments. Various methods of r manufacturing the inventive compounds are provided and pharmace...
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WO/2011/063110A1 |
The present invention generally relates to a process for preparing 2,2- dibromomalonamide from 2,2-dibromo-3-cyanoacetamide.
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WO/2011/062052A1 |
Disclosed are: a novel fluorene compound which is capable of providing an organic material such as a polymer with high processing stability, high heat resistance and long life without using a secondary antioxidant; a stabilizer which con...
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WO/2011/058932A1 |
Disclosed is a compound represented by formula (I0) or a salt thereof. In the formula, R1 represents a methyl group or the like; R2 represents H or the like; L represents -NH-(C=O)- or the like; and Z represents a group that is represent...
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WO/2011/060302A1 |
The embodiments described herein provide a reduction of an aldehyde or a ketone, such as a Meerwein-Ponnorf-Verley (MPV) reaction of an aldehyde or ketone. In some embodiments, the reaction occurs in the presence of A1[OC(CH3)3]. In some...
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WO/2011/054436A2 |
The invention relates to halogen-substituted amide derivatives of general formula (I), in which R1 to R6, Q1 to Q8, A, V, W, X, Y, n and m are defined as cited in the description. The invention also relates to a method for producing same...
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WO/2011/054917A1 |
The invention provides a process for the preparation of the polymorph from I of agomelatine, characterized by the following crystal data: C15H17NO2 Mr = 243.30 Orthorhombic Pca21 a = 31.501 (4) A b = 9.5280 (1 O) A C = 17.906 (2) A Z = 1...
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WO/2011/051165A1 |
The present invention relates to novel 3-phenylpropionic acid derivatives, to a method for the production thereof, to the use thereof for treating and/or preventing diseases, and to the use thereof for producing medications for treating ...
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WO/2011/050742A1 |
Three new crystalline forms of Agomelatine, their preparation methods and the pharmaceutical compositions containing them and their preparation use of drug used for curing the diseases of central nervous system are provided. These three ...
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WO/2011/051375A1 |
(R,S) 2-aryl-propionamide derivatives, or their single enantiomers (R) and (S) are disclosed useful in the treatment or prevention of symptoms and disorders such as pain and inflammation associated with the bradykinin B1 pathway.
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WO/2011/048004A1 |
This invention relates to compounds of formula I, their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevent...
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WO/2011/048091A1 |
A novel process for the preparation of a phenylalanine derivative of formula (I):
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WO/2011/047432A1 |
The present invention relates to arylcarbonyl and heteroarylcarbonyl anthranilate compounds that may be useful as anti-fibrotic agents. The present invention also relates to methods for their preparation, pharmaceutical compositions cont...
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WO/2011/046007A1 |
Provided is a process for preparing easily and efficiently an intermediate compound for use in the synthesis of a gadolinium complex which has a substituent capable of improving retention in blood or organ specificity. Also provided is a...
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WO/2011/046954A1 |
The present embodiments relate to compounds with physiological effects, such as the activation of hematopoietic growth factor receptors. The present embodiments also relate to use of the compounds to treat a variety of conditions, diseas...
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WO/2011/044225A1 |
The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.
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WO/2011/044195A1 |
The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.
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WO/2011/038572A1 |
The present invention discloses novel compounds inhibiting LRRK2 kinase activity, the preparation processes thereof, the compositions containing them, as well as the use in treating diseases characterized by LRRK2 kinase activity, partic...
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WO/2011/039746A1 |
Amide derivatives of valproic acid are provided along their use in the treatment of epilepsy.
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WO/2011/035569A1 |
A novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, in particular neutral endopeptidase (NEP) inhibitors.
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WO/2011/037833A2 |
A first aspect of the invention is a compound (sometimes also referred to herein as an "active agent" or "active compound") of Formula Ia, or more particularly Formula Ib, or a pharmaceutically acceptable salt or prodrug thereof. Composi...
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WO/2011/032277A1 |
Compounds of formula I: (I) wherein X, R2, R3, R5 and R6 are defined herein, are useful as inhibitors of the hepatitis C virus NS5B polymerase.
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WO/2011/031042A2 |
The present invention relates to a PEGylated triiodinated aryl compound and to an X-ray contrast agent comprising same. The PEGylated triiodinated aryl compound of the present invention not only exhibits low viscosity and osmolarity, but...
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WO/2011/027106A1 |
The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-amido-aryl compounds of the following formula (for convenience, collectively referred to herein as "AAA compounds"), wh...
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WO/2011/025790A1 |
The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quant...
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WO/2011/022805A1 |
The invention relates to colchicine derivatives, methods and uses thereof for treatment of cancer. In certain embodiments, the colchicine derivative comprises a compound of formula (I), wherein Z is O or S; R1 is selected fro H, a halo g...
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WO/2007/054776A9 |
The present invention relates to novel stilbene like compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, m...
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WO/2011/023667A1 |
The present invention relates to the use of a compound of general formula (I) wherein R1/R2 are independently from each other hydrogen, lower alkyl, -CH2)o-cycloalkyl for o being 0 or 1, or are benzyl or heterocycloalkyl; or R1 and R2 ar...
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WO/2011/023324A1 |
The present invention relates to a process for producing substituted biphenyls by reacting aryl halides with tetraarylborates in the presence of palladium catalysts.
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WO/2011/021623A1 |
Disclosed is a compound represented by formula (a): CH2=CR1-CONJ-CKR2-(CH2)n-COO-Q1-Rf1, which is capable of forming a polymer having oil repellency equivalent to that of a conventional polymer containing a polyfluoroalkyl group having 8...
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WO/2011/021397A1 |
Provided are 4-modified colchicine compounds and medicines using the same. Specifically provided are colchicine derivatives represented by general formula (1), salts thereof, and solvates of the same. In general formula (1), R1 is a halo...
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WO/2011/018170A2 |
The object of the present invention is to provide novel carboxamides which exhibit an excellent pesticidal activity as pesticides. Disclosed are the carboxamides represented by the following Formula (I) wherein each substituent is as def...
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WO/2011/010610A1 |
Provided is a catalyst precursor, which has excellent safety and stability, has a high stable activity retention rate, is capable of repeated use, has a high reaction recovery rate, and is easily worked into various shapes. The catalyst ...
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WO/2011/009540A2 |
To provide novel carboxamides which exhibit an excellent pesticidal activity as pesticides. Carboxamides represented by the following Formula (I) and use thereof as pesticides and an animal parasite control agent wherein each substituent...
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WO/2011/007807A1 |
Provided is an amide ester that is useful as an intermediate manufacturing product for an aroma compound such as spilanthol or the like. Also provided is a spilanthol manufacturing method using said amide ester. High-purity spilanthol ca...
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WO/2011/006387A1 |
The preparing process of agomelatine is provided, which comprises reacting 7-methoxy-1-tetralone with a cyano compound in presence of n-butyllithium (n-BuLi) to obtain 2-(1,2,3,4-tetrahydro-1-hydroxyl-7-methoxy-1-naphthyl)aceton
itrile, ...
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WO/2011/000459A1 |
The invention relates to a continuous method for producing amides of aromatic carboxylic acids by reacting at least one carbonic acid ester of formula (I) R3-COOR4, wherein R3 represents an optionally substituted aromatic hydrocarbon gro...
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WO/2011/000537A1 |
Method of preparing 1-chloroacetamido-1,3,3,5,5-pentamethylcyclohexane, an intermediate in the synthesis of 1-amino-1,3,3,5,5-pentamethylcyclohexane (Neramexane) or a pharmaceutically acceptable salt thereof, comprising step (iii): (iii)...
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WO/2011/002339A2 |
The invention relates to peptide mimetics, more specifically to pharmaceutically acceptable salts of (S)-N-[4-(1-adamantyl)benzoyl]-α-amino acids of the general formula (1), where A+ is an ion of an alkali metal, ammonium and N+(C1-4alk...
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WO/2011/003061A2 |
Methods of producing compositions of trans-4-amino-2-cyclopentene-1-carboxylic acid derivatives are described. Also described is an amine salt of a compound having formula A, having components present in both cis and trans structures.
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WO/2010/150564A1 |
A compound represented by formula (I), which has an effect of promoting the folding of a mutant rhodopsin and is useful as the active ingredient of a drug for preventing and/or treating retinitis pigmentosa, or a salt thereof [in formula...
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WO/2010/150816A1 |
Disclosed is a composition including at least one compound represented by formula (Z): A-L-{D1-(E)q-D2-(B)m-Z1-R}p (Z), where A is a linear or cyclic residue having a valence of p; L is a single bond or a divalent linking group; p is an ...
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