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WO/2012/065110A2 |
S-protected cysteine analogs and related compounds and methods of using these compounds for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of Central Nervous System (CNS).
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WO/2012/060396A1 |
The purpose of the present invention is to provide a novel trans-2-decenoic acid derivative and a pharmaceutically acceptable salt thereof, and a medicament containing the compound described above as an active component and having a neur...
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WO/2012/059443A2 |
The invention relates to novel acylamino-hydroxy-benzamides of formula (I), wherein R1 is phenyl substituted by phenyl, phenoxy, phenylamino or heteroaryl, all optionally further substituted; bicyclic aryl, monocyclic heteroaryl substitu...
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WO/2012/058866A1 |
Provided are a benzamide derivative as shown in formula (I) or a pharmaceutically acceptable salt thereof, and the preparation method and use thereof for preparing a medicine for treating cancer, wherein the group definitions of formula ...
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WO/2012/052550A1 |
Disclosed are novel cross-linkable end-cappers for oligo-and polyamides. End-capped oligo-and polyamides comprising such an end-capper may be cured at a lower temperature compared to oligo-and polyamides end-capped with PEPA.
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WO/2012/052163A1 |
Dental cement composition comprising (i) a particulate filler reactive with a polyacid in a cement reaction; (ii) a water-soluble polymerizable compound of the following formula (1), AXn (1) wherein A is a linker group containing at leas...
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WO/2012/052829A1 |
The present invention provides novel process for the preparation of renin inhibitor Aliskiren or its derivatives, and its pharmaceutically acceptable salts. The present invention also provides novel intermediates used in the preparation ...
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WO/2012/052160A1 |
Dental composition comprising a water-soluble polymerizable compound of the following formula (1): wherein A is a linear or branched linker group represented by the following formula (3), wherein the nitrogen atom of at least two of the ...
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WO/2012/052161A1 |
Dental composition comprising (i) a particulate filler; (ii) a polymerizable hydrolysis-stable compound of the following formula (1) AXn wherein A is a linker group containing at least n nitrogen atoms and optionally one or more acidic g...
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WO/2012/049338A1 |
The present invention describes vinyl sulfone-derived compounds that comprise a core of PAMAM derivatized with alkyl sulfonyl groups, and the method for production thereof. These compounds form complexes with DNA fragments that are usefu...
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WO/2012/048845A1 |
Disclosed are halogenated diethyltoluenediamines of formula I, wherein either R1 is an amino group and R2 is chlorine or bromine, or R2 is an amino group and R1 is chlorine or bromine, and isomeric mixtures thereof. The halogenated dieth...
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WO/2012/050623A2 |
The present invention provides a process for the synthesis of substituted phenoxymethylpropionic acid and related compounds. The compounds are useful for inhibiting the formation of AGEs (Advanced Glycation End Products).
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WO/2012/047251A1 |
Low molecular weight gelators, methods of making such gelators, organogels comprising such gelators and systems and methods of using such gelators for the containment and/or remediation of a release and/or spill of a crude oil, a petrole...
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WO/2012/045734A1 |
The present invention relates to phenyl diamides according to the general formula (1) and their use as a medicament and a pharmaceutical preparation comprising as an active ingredient a phenyl diamide according to the general formula (1)...
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WO/2012/046253A2 |
The present invention relates to a process for the preparation of N-[2-(7-methoxy-l-naphthyl)ethyl]acetamide compound of formula-1 and novel crystalline forms of its intermediates as well as the final compound.
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WO/2012/042608A1 |
Provided is a novel 3-aminobenzoic acid derivative, said derivative being useful as an intermediate in the production of a 3-oxamoylaminobenzamide derivative which has a pesticidal and miticidal activity, and a method for producing the s...
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WO/2012/040922A1 |
A method for preparing N2-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-N6-trifluoroacetyl -L-lysine is provided. The method comprises: adding crude N2-[1-(S)-ethoxy carbonyl-3-phenyl-propyl]-N6-trifluoroacetyl-L-lysine to an organic solvent, ad...
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WO/2012/042621A1 |
Provided are a compound having a salty taste enhancing action and a salty taste enhancer and the like containing that compound. The salty taste enhancer, which is for food products, contains a compound represented by Formula (I) or an ed...
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WO/2012/038963A1 |
An acid addition salt of a nortriptyline-GABA conjugate, a novel crystalline form of a fumaric acid addition salt of a nortriptyline-GABA conjugate, and processes of preparing the forgoing are disclosed. Uses of the above-indicated forms...
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WO/2012/034991A1 |
The invention relates to a method for producing formamides by reacting carbon dioxide (1) with hydrogen (2) in a hydrogenation reactor I in the presence of: a catalyst, containing an element from group 8, 9 or 10 of the Periodic Table, a...
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WO/2012/016314A9 |
The present invention describes the production of arachidonic acid-derived coxib analogue-substituted compounds and salts thereof for use in treating pain. Furthermore, the invention relates to pharmaceutical compositions containing arac...
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WO/2012/031466A1 |
Disclosed are 2-(p-octylphenylethyl)-2-amino propanediol derivatives of formula (I) and uses thereof wherein, R1, R2, R3 is selected independently from H or acyl; R4 is selected from methylene, carbonyl, (II) or (III); R5 is trans-4-meth...
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WO/2012/029276A1 |
The present invention addresses the problem of providing a recording material or sheet which is excellent not only in the whiteness of non-image areas but also in the storage of non-image areas and images and which exhibits excellent col...
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WO/2012/029968A1 |
For many years, many insecticides, miticides, nematicides or soil pesticides have been used, but many of them have various problems such that the effects are inadequate, their use is restricted as insects, etc. have acquired resistance, ...
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WO/2012/029672A1 |
The present invention relates to amine derivatives each represented by chemical formula (I) (wherein Ar represents a phenyl group or the like; R1 represents a hydrogen atom or the like; R2 represents a C1-6 alkylcarbonyl group or the lik...
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WO/2012/028676A1 |
The invention relates to new compounds of the formula (I) to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
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WO/2012/029794A1 |
The present invention provides an aromatic compound containing a specific branch. This aromatic compound containing a specific branch is easily soluble in isopropyl acetate, which is excellent for separating liquids, and can be used for ...
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WO/2012/026639A1 |
The present invention relates to a novel compound having an acceleration effect on the secretion of human β-defensin, LL-37, which is a human-derived anti-microbial peptide, a method for preparing same, and a composition for acceleratin...
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WO/2012/026403A1 |
A condensed ring compound capable of becoming an intermediate product suitable for isoxazolines is represented by formula (I). In formula (I), X" represents a halogen atom or the like; n represents any one of integers 0 to 5; X' represen...
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WO/2012/026886A1 |
The invention includes a compound represented by the following structural formula: wherein R is described herein. The compounds of the invention are useful in staining embryonic stem cells.
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WO/2012/026743A2 |
Disclosed is a compound that uses a hydrogen isotope that is capable of reducing costs for labeling agent synthesis and also simultaneously quantifying multiple samples. The present invention also relates to a novel method of quantitativ...
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WO/2012/021788A2 |
Compounds, pharmaceutically acceptable salts thereof, and compositions useful as calpain inhibitors are disclosed. Certain compounds are also useful for the treatment of acute or chronic neurodegenerative disorders. Other compounds are u...
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WO/2012/020483A1 |
A 3-aminooxalyl aminobenzamide derivative used in an insecticide and miticide is provided. The 3-aminooxalyl aminobenzamide derivative is represented by the following formula. (In the formula, R1 represents a C1 to C3 halo alkylthio grou...
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WO/2012/020484A1 |
A 3-aminooxalyl aminobenzanilide derivative used in an insecticide and miticide is provided. The 3-aminooxalyl aminobenzanilide derivative is represented by the following formula. (In the formula, R1 and R2 are both halogen atoms; R3 and...
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WO/2012/021800A2 |
Compounds, pharmaceutically acceptable salts thereof, and compositions useful as caspase inhibitors are disclosed. Certain compounds are also useful for the treatment of neural or organ injury. Other compounds are useful as neural and or...
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WO/2012/017966A1 |
The invention addresses the problem of providing complex compound catalysts that have high catalytic activity, are inexpensive and do not have the theoretical production limitations of solid catalytic methods (problems of contamination w...
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WO/2012/014760A1 |
Disclosed is a method for producing a carboxylic acid amide, which involves a step in which a carboxylic acid ester represented by formula (1) (in the formula, R1 represents an optionally substituted C1-20 hydrocarbon group or an optiona...
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WO/2012/011693A2 |
Provided are a cationic lipid, a production method for the same and a vehicle comprising the same. The present invention can provide: a cationic lipid which improves the efficiency with which various anionic target compounds such as drug...
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WO/2012/005317A1 |
Provided are: a methylenebis(fatty acid amide) composition which exhibit stable adhesive characteristics and peeling characteristics under various environmental conditions and which can minimize the stains of an adherend; a pressure-sens...
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WO/2012/005200A1 |
An industrially advantageous method for producing an optically active 1,2-bis(dialkylphosphino)benzene derivative, wherein borane is removed from a phosphine-borane compound (1), followed by lithiation, then the reaction product is react...
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WO/2012/003145A2 |
This invention provides well defined 6-alkyl or hydroxyalkyl-1-naphthamide or quinoline compounds for treating glaucoma or ocular hypertension.
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WO/2012/001191A1 |
The invention relates to a family of compounds having a structural nucleus of amino alcohol derivatives and to the use thereof for the detection of Farber's disease, using a diagnosis method performed outside the human body, comprising t...
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WO/2012/001151A1 |
The present invention relates to a salt selected from the group comprising the N-methyl-D- glucamine salt (NMG), the diethylamine salt (DEA) salt, the magnesium salt, the tromethamine salt, the choline salt, the L-arginine salt, the zinc...
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WO/2011/061330A9 |
The invention relates to a TRPM8 modulator for achieving a cooling effect on skin or mucous membrane.
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WO/2012/001148A1 |
The present invention relates to calcium salts of compounds of the general formula (I) wherein X is selected from the group consisting of CH2, S, or O; D is O or S; R8 is hydrogen or alkyl; E is an optionally substituted phenylene group;...
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WO/2011/163502A1 |
The invention provides well defined compounds having FPRL-1 agonist or antagonist activity. As such, the compounds of the invention are useful for treating a variety of ocular disorders.
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WO/2011/159781A2 |
The present invention includes antagonists of human type 2 taste receptors (hT2Rs) having structural Formula (I). The present invention also provides compositions containing these antagonists, the use of these antagonists for modulating ...
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WO/2011/157986A1 |
The present invention relates to a process for the preparation of substantially pure nateglinide of formula (I), substantially free from the cis-isomer and L-enantiomer and preparation of enantiomerically pure nateglinide form B, directl...
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WO/2011/158918A1 |
Disclosed is a novel polynuclear metal compound which is specific, has high catalytic properties, and has great potential as a novel functional material or the like. Specifically disclosed is a polynuclear metal compound which has at lea...
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WO/2011/154140A2 |
A novel process for the preparation of N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide, also known as agomelatine, Compound (I), from 7-methoxy-tetralone as starting material, and to a new crystalline form X of agomelatine.
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