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WO/2010/081788A1 |
The present invention relates to a new process for the preparation of N-[5-(3-dimethylamino-acryloyl)-2-fluoro-phenyl]-N-methyl-ac
etamide (I) in a high yield and high purity, which is an intermediate in the synthesis of compounds with a...
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WO/2010/081410A1 |
Process for manufacture and resolution of 2-acylamino-3-diphenylpropanoic acid and intermediates useful in the synthesis of pharmaceutically active compounds, in particular neutral endopeptidase (NEP) inhibitors.
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WO/2010/080795A2 |
Provided is a complex of hydrogen peroxide and at least one compound represented by Formula (I): wherein X is ( ), -C(R3)3, -C=C(R3), -O(R3), -N(R3)2, or -S(R3); and R1, R2, and R3 are each independently selected from H, alkyl, alkenyl, ...
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WO/2010/079774A1 |
An N-(1-hydroxyethyl)carboxamide compound represented by general formula (1), a process for producing the compound, a process for producing an N-(1-alkoxyethyl)carboxamide compound, a process for producing an N-vinylcarboxamide compound,...
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WO/2010/072480A1 |
A novel method is described, which allows n-isopropyl(meth)acrylamide to be obtained in a simple way in high purity and high yield in that methacrylic acid anhydride is reacted with isopropylamine, optionally in a solvent.
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WO/2010/072166A1 |
The invention provides a new kind of dihydroindene amide compounds of general formula I or their pharmaceutically acceptable salts or prodrug thereof which can be used as protein kinase inhibitor. The invention provides a preparation met...
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WO/2010/072543A1 |
The invention relates to a method for producing N-vinylcarboxamides by pyrolyzing a compound of the formula (I), in which R and R1 stand for H or C1 to C6 alkyl, in the presence of solids that are doped with alkali metal or alkaline-eart...
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WO/2010/072727A1 |
The present invention relates to new retinoid derivatives of Formula (I), and to pharmaceutical compositions containing them for the treatment of patients affected by pathologies such as arthritic conditions, tumours, metastatic cancer, ...
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WO/2010/069266A1 |
The heterocyclic nitrogenous or oxygenous compounds of formula (A), (B), (C) or (D) formed from dialdehydes, their optical isomers, cis- and trans- isomers, or agrochemically acceptable salts, their preparation methods, agrochemical comp...
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WO/2010/069854A2 |
Described is a method for modifying the thermal softening behaviour of a polyolefin wax, which comprises the incorporation into the wax of at least one compound of the formula (I) wherein Q is a C3-C12alkyltriyl, a tris(C1-C8alkylene)ami...
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WO/2010/069758A1 |
A polymerizable photoinitiator represented by Formula (I): wherein R1, R2 and R3 are independently selected from the group consisting of a hydrogen, an optionally substituted alkyl group and an optionally substituted aryl group or R1 and...
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WO/2010/070076A1 |
The invention related to alkanoic acid derivatives of Formula (IIa) and (IIb). These compounds of the invention were found to have activity as HDAC inhibitors.
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WO/2010/070167A1 |
The invention relates to various haptens derived from bromopropylate (BP), the uses thereof for the synthesis of immunoreagents and an immunochemical method for bromopropylate (BP) detection and/or quantification, as well as the respecti...
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WO/2010/069561A1 |
The present invention relates to co-crystals of tramadol and paracetamol, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.
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WO/2010/066909A2 |
The present invention relates in general to a compound which is characterized by a formula selected from the following formulas A, B, C, D, E or F; or a pharmaceutically acceptable salt thereof. The present invention further relates to p...
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WO/2010/067069A1 |
The present invention concerns compounds derived from the anaethetic propofol. The compounds may be useful in the treatment of pain, particularly, but not exclusively, chronic pain and central pain sensitisation.
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WO/2010/066912A2 |
The present invention relates to a compound which is characterized by the formula (I) or a pharmaceutically acceptable salt, solvate, hydrate thereof, wherein the ring systems A and B are independently selected from a monosaccharide, ary...
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WO/2010/064785A2 |
The present invention relates to a method for selectively crystallizing Z isomer of iopromide of formula (I) comprising a) dissolving a crude iopromide comprising a mixture of E and Z isomers or a concentrate thereof in an alcohol, and b...
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WO/2010/063080A1 |
Amphiphilic prodrugs of general formula A-X are disclosed, wherein A is a biologically active agent or may be metabolised to a biologically active agent; and X is selected from the group consisting of R, or up to three R moieties attache...
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WO/2010/061621A1 |
Disclosed is a method for manufacturing, efficiently and with high yield, a trans-{4-[(alkyl amino) methyl] cyclohexyl} acetic ester which is useful as a starting material compound for the manufacture of medicines and the like, said meth...
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WO/2009/074020A9 |
Disclosed are α-amino-N-substituted amide compounds having the following structure or their pharmaceutically acceptable salts, and pharmaceutical compositions containing said compounds or their pharmaceutically acceptable salts. The pre...
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WO/2010/062239A1 |
A new catalytic asymmetric two-step or one-pot method for the preparation of the C-13 side-chain of paclitaxel (Taxol) and derivatives of the general formula (I) in the form of an acid, salt or ester, in which R represents an aryl group ...
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WO/2010/057874A1 |
The present invention relates to a process for preparing secondary amides with good selectivity by carbonylating a corresponding tertiary amine with carbon monoxide in a reaction mixture in the presence of a metal catalyst and in the pre...
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WO/2010/058577A1 |
Disclosed is a method for producing an unsaturated aminocarboxylic acid derivative, which is useful as a pharmaceutical raw material, at low cost. Specifically, an unsaturated aminocarboxylic acid derivative is produced by hydrolyzing a...
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WO/2010/055911A1 |
A compound represented by formula (I) or a salt thereof, which is useful as an agent for treatment or prevention of various epileptic seizures, namely partial seizures and/or generalized seizures. (In the formula, R1, R2 and R3 may be th...
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WO/2010/050516A1 |
Disclosed is a method for producing an L-amino acid by allowing L-succinylase to act on a mixture of N-succinyl amino acid enantiomers in the coexistence of N-acylamino acid racemase to specifically hydrolyze the L-form. In particular, ...
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WO/2010/044685A1 |
The invention provides nitrophenyl mustard compounds useful in cancer therapy as targeted cytotoxic agents, of Formula (I) and Formula (II): wherein X represents C1, Br, I, or OSO2R1, Y represents C1, Br, I, or OSO2R1, Z represents at an...
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WO/2010/041847A2 |
Disclosed are a gene carrier in which poly(ethyleneglycol) is conjugated with polyethylenimine and a method for the synthesis thereof. The gene carrier is useful in transferring DNA, siRNA and negatively charged peptides.
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WO/2010/040843A2 |
The invention relates to compounds of formula (I), in which R1, R2, R3, R4, X and Y are defined as cited in the description. The compounds have an immune-modulating action and inhibit or regulate the release of IL-1β and/or TNF-α. They...
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WO/2010/041748A1 |
Disclosed is a prophylactic or therapeutic agent for diabetes, diabetic complications, insulin resistance syndrome, metabolic syndrome, hyperglycemia, dyslipidemia, atherosclerosis, heart failure, cardiomyopathy, myocardial ischemia, cer...
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WO/2010/038633A1 |
Disclosed is a production process which can produce a trans-dicyclohexane derivative in high yield. The production process comprises hydrogenating a specific phenyl-trans-cyclohexane derivative in the presence of a rhodium catalyst to pr...
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WO/2010/039793A1 |
The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds ...
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WO/2010/037271A1 |
A group of amino substituted benzoyl derivatives, their preparation and their use. The screening and research on an antiviral drug with hA3G/Vif as a target point proves that the 3-amino benzoyl derivatives not only have inhibiting the c...
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WO/2010/034236A1 |
A novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active N-acylbiphenyl alanine compounds, in particular neutral endopeptidase (NEP) inhibitors.
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WO/2010/034917A2 |
The invention relates to a compound of the formula (I) where m is an integer equal to 0 or 1, and p is an integer equal to 0, 1, 2 or 3. The invention also relates to a method for preparing same, to the use thereof as a skin lightening a...
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WO/2010/032771A1 |
Disclosed is a novel amino acid derivative having excellent analgesic activity. The amino acid derivative is a novel compound which exhibits excellent analgesic activity not only with respect to nociceptive pain model animals, but also w...
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WO/2010/031867A1 |
The invention relates to novel products containing diamide compounds, to the uses of said products, and to at least one method for preparing same. The products can particularly be used as solvents, e.g. in phytosanitary formulations.
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WO/2010/026325A1 |
The invention relates to the use of an N-acyl amino acid selected from among N-palmitoyl alanine, N-palmitoyl glycine, N-palmitoyl isoleucine, and N-cocoyl alanine as an active agent controlling the proportion of basal keratinocytes of t...
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WO/2010/026119A1 |
The invention relates to a (meth)acrylate monomer of general formula (I), where R1 represents hydrogen or a methyl group, X represents oxygen or a group of formula NR' in which R' represents hydrogen or a group comprising 1 to 6 carbon a...
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WO/2010/027051A1 |
Disclosed is a novel intermediate for producing a substituted isoxazoline compound that is useful as a harmful organism control agent. Specifically disclosed are: a substituted acetophenone compound represented by general formula (1) or ...
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WO/2010/023390A1 |
The invention relates to use of an N-acyl amino acid selected from among N-palmitoyl alanine, N-palmitoyl glycine, and N-palmitoyl isoleucine as a regulating active agent of the genetic profile of senescent replicating fibroblasts of the...
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WO/2009/030964A9 |
The compounds of general formula (I) wherein: R1 is hydrogen, phenyl, C1-6 alkyl which can be further substituted with R3 R3 is 5- or 6- membered aromatic or heteroaromatic ring system which can be further substituted with benzyl or hydr...
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WO/2010/021956A2 |
Methods of producing the N-alkyl (alkyl)acrylamides. In a general embodiment, the present disclosure provides a method of producing an N-alkyl (alkyl)acrylamide comprising providing an aqueous solution comprising an N-alkyl amine and add...
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WO/2010/019646A1 |
The invention provides certain well-defined benzamides that are useful as sphingosine-1-phosphate antagonists. As such, the compounds described herein are useful in treating a wide variety of disorders associated with modulation of sphin...
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WO/2010/018023A1 |
The present invention relates to a process for producing an aqueous methacrylamide solution, where water is passed through a fixed bed which comprises methacrylamide as solid. The present invention further describes a solids container an...
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WO/2010/018047A2 |
The invention relates to compositions comprising at least one oil from the fruit of a sumac plant.
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WO/2010/019730A1 |
The present invention provides synthetic routes for preparing various isomers of cyclohexane-based coolants, such as menthyl esters and menthanecarboxamide derivatives, in particular those substituted at the amide nitrogen, for example w...
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WO/2010/015655A1 |
There are described cyclohexyl amide derivatives useful as corticotropin releasing factor (CRF1) receptor antagonists.
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WO/2010/015747A1 |
Process for obtaining the crystalline form V of the compound of formula (I), characterised in that a solution of agomelatine dissolved in one or two miscible solvents in all proportions and having a boiling temperature of less than 120°...
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WO/2010/015744A1 |
Process for the industrial synthesis of the compound of formula (I), characterised in that the (7-methoxy-1-naphtyl)acetonitrile of formula (II) is reacted and subjected to a hydrogen reduction in the presence of Raney nickel in a medium...
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