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Matches 451 - 500 out of 7,756

Document Document Title
WO/2015/117146A1
β-Substituted -amino acids, β-substituted γ-amino acid derivatives, and β-substituted γ-amino acid analogs and (bio)isosteres and their use as chemotherapeutic agents are disclosed. The β-substituted γ-amino acid derivatives and ...  
WO/2015/115650A1
Provided is a method for producing an optically active carboxylic acid ester at a high yield and with high enantioselectivity using dynamic kinetic resolution, said optically active carboxylic acid ester having an α-nitrogen substituent...  
WO/2015/116786A1
In one aspect, the invention relates to compounds having the formula (I): where R1-R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another asp...  
WO/2015/117147A1
β-Substituted β-amino acids, β-substituted β-amino acid derivatives, and β-substituted β-amino acid analogs and (bio)isosteres and their use as chemotherapeutic agents are disclosed. The β-substituted β-amino acid derivatives and...  
WO/2015/109935A1
The invention generally relates to compounds of formula (I) with neural protective effect, and preparation and uses thereof. The compounds have multiple mechanisms or functions, for example, inhibition of monoamine oxidase and cholineste...  
WO/2015/109666A1
Disclosed are an ester group-containing aromatic propionamide compound, and a preparation method therefor and uses thereof, and provides a chemical structure formula of the new ester group-containing aromatic propionamide compound. The c...  
WO/2015/107064A1
The present invention relates to methods for linking tetrazines with dienophiles to establish at least two linkages by sequentially performing at least two cycloaddition reactions. The methods in particular allow establishing multi-label...  
WO/2015/093469A1
The present invention involves preparing compounds represented by the formula. (In the formula: R1 represents a Br group, an iodine group, a Cl group, an NO2 group, or an NH2 group; R2 represents a halogen group, an NO2 group, an NH2 gro...  
WO/2015/087341A1
The present invention relates to an improved process for the preparation of dimethyl carbonate and methyl-N-methyl carbamate starting from methanol and methyl carbamate catalyzed by ionic liquid catalyst in batch or continuous reactor.  
WO/2015/077451A1
The present invention relates to N-phenyl carbamate derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide 2 receptor.  
WO/2015/076346A1
An optically active 2,6-dimethyltyrosine derivative represented by formula (1) (wherein R1 represents a hydrogen atom or a protecting group for a phenol group; R2 represents a protecting group for an amino group; and * represents an asym...  
WO/2015/075744A1
The present invention relates to novel carbamate intermediate of formula (II), process for its preparation and process for its conversion into 3-[(1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol, tapentadol and its pharmaceuticall...  
WO/2015/074085A1
What is described is a compound of formula (I), wherein R1 and R2 are the same or different, each a linear or branched alkyl with 1-9 carbons, or an alkenyl or alkynyl with 2 to 11 carbon atoms; L1 and L2 are the same or different, each ...  
WO/2015/060359A1
Provided are a novel diamine, and a polyimide precursor and polyimide using the same. A diamine represented by formula (1). (In formula (1), X1 and X5 each independently represents a single bond or the like, X2 and X4 each independently ...  
WO/2015/055447A1
The present invention relates to a process for preparing substituted isatoic acid anhydride compounds of the formula (I) in which R1 is Cl, Br, I, or CN; and R2 is CH3, Cl, Br; using anthranilic acid derivative compounds of formula (III)...  
WO/2015/054476A1
Methods of halogenating a carbon containing compound having an sp3 C-H bond are provided. Methods of fluorinating a carbon containing compound comprising halogenation with Cl or Br followed by nucleophilic substitution with F are provide...  
WO/2015/039172A1
The present invention relates to novel compounds and their use in the prophylactic and/or therapeutic treatment of hypertension and/or fibrosis.  
WO/2015/036550A1
The invention relates to an improved process and novel intermediates (4) and (6) for the preparation of pharmaceutically active compound etoricoxib of formula (1).  
WO/2015/037460A1
Optically active 3-(biphenyl-4-yl)-2-[(t-butoxycarbonyl)amino]propan-1-ol can be produced through: a step of reacting an optically active biphenylalanine compound represented by formula [I] with a reducing agent to produce an optically a...  
WO/2015/032939A1
A solid catalyst component for the polymerization of olefins comprising Mg, Ti and an electron donor of formula (I), where R1 is selected from C1-C15 hydrocarbon groups, R2 groups, equal to or different from each other, are hydrogen or R...  
WO/2015/032357A1
Zanamivir, a Zanamivir intermediate compound (formula 2), and a preparation method therefor. The preparation method is method 1 or 2. Method 1 comprises the following steps: compound 3 undergoes a reaction to remove a protecting group so...  
WO/2015/030106A1
The present invention relates to compounds represented by general formula (I) (where Z, R, Ra, R', * and n are each as defined in the description) or salts thereof.  
WO/2015/025960A1
Provided are: a compound having high activity against harmful organisms; a harmful organism control agent comprising the compound; and a method for controlling harmful organisms by applying the compound. A phenoxyalkylbenzamide-type comp...  
WO/2015/025773A1
This method for producing an m-xylylene diisocyanate contains: a reaction step for generating a bisamide compound by reacting, in the presence of an acidic liquid, a monohalogenated benzene, formaldehyde, and an amide compound indicated ...  
WO/2015/025826A1
The purpose of the present invention is to provide: a novel substituted phenyl ether compound which has a control effect against pests; and a pest control agent which contains this substituted phenyl ether compound as an active ingredien...  
WO/2015/024991A1
The invention relates to a novel synthesis route towards R- biphenylalaninol and to the intermediates applied in this synthesis route. The process according to the invention and the intermediate compounds are useful in the synthesis of p...  
WO/2015/016263A1
The present invention relates to a reaction method having a step for supplying a liquid including at least one species of a raw material compound and a low-boiling compound having a standard boiling point lower than the standard boiling ...  
WO/2015/010436A1
Disclosed is a new Carfilzomib intermediate and a preparation method therefor, and a preparation method for Carfilzomib using the intermediate. The Carfilzomib intermediate provided by the invention is easily separated from the isomers t...  
WO/2015/012407A1
The present invention pertains to a cellulose acylate film containing a compound having at least one linking group selected from the group consisting of a bivalent linking group represented by -NH-(C=O)-O- and a bivalent linking group re...  
WO/2015/012258A1
A composition including: a polymerizable compound (A) having a (meth) acryloyl group and an isocyanate group in each molecule; and a reaction accelerator (B) comprising a compound having a (meth) acryloyl group and a carbamoyl halide gro...  
WO/2015/012259A1
Provided is a reaction accelerator used in a reaction between a compound having an isocyanate group that does not directly bond to an aromatic ring, in each molecule, and a compound having an active hydrogren-containing group. The reacti...  
WO/2015/010014A1
The present invention relates to a method for treating or preventing obesity in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of certain carbamate compounds. The invention further r...  
WO/2015/007897A1
The present invention provides a very simple, efficient and economic technology for racemisation of amines, alcohols or thioalcohols where the chiral carbon (benzylic position) is located at the β-position of the heteroatom (amino, hydr...  
WO/2015/006685A1
The present invention relates to a method for promoting cessation or reduction in the smoking and/or chewing of tobacco or nicotine-containing products in a subject in need thereof, comprising administering to the subject an effective am...  
WO/2014/207071A1
The present invention relates to novel strobilurine type compounds, to compositions comprising at least one such compound, to methods for combating phytopathogenic fungi, to the use of such compounds and to seeds coated with at least one...  
WO/2014/202703A1
The present invention relates to novel strobilurine type compounds I, processes for preparing these compounds, a use of compounds of the formula I and/or their agriculturally useful salts for controlling phytopathogenic fungi, to composi...  
WO/2014/200094A1
[Problem] To provide a novel production method for a stereoselective, optically active alcohol compound. [Solution] From the compound represented by formula (3), the optically active alcohol compound represented by formula (8) can be pro...  
WO/2014/185856A1
The present invention relates to functionalized cyclic carbonates, urethanes and polyurethanes, their methods of production and uses thereof.  
WO/2014/183221A1
Resveratrol analogs and their use to inhibit Kv1.5 channels are provided. The resveratrol analogs are useful in the treatment of atrial arrhythmias, including atrial fibrillation (AF). Exemplary resveratrol analogs are compounds of gener...  
WO/2014/184116A1
The invention relates to new carbodiimides having terminal urea and/or urethane groups of formula (I), wherein R can be the same or different and is selected from the group of the -NHCONHR', -NHCONR'R'', and -NHCOOR''' residues. The inve...  
WO/2014/179859A2
A polymorphic form APO-I of Ezogabine, processes for the preparation thereof and pharmaceutical formulations comprising the polymorphic form APO-I are provided.  
WO/2014/164969A1
The present invention relates to a method of treating cataplexy in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of certain carbamate compounds.  
WO/2014/163016A1
This xylylene dicarbamate contains impurities represented by formulas (1)-(4) in a ratio such that the total thereof constitutes less than 100ppm on a mass basis. (In formulas (1)-(4), R represents a monovalent hydrocarbon group.)  
WO/2014/157653A1
The present invention addresses the problem of providing an efficient process for preparing important intermediate compounds (1) and (1a) for the production of FXa inhibitors (X) and (X-a). The present invention pertains to: a process wh...  
WO/2014/155264A1
The present invention provides an improved and commercial process for the preparation of Lacosamide having formula (I). Further, the present invention also provides the novel intermediate compounds of formula (VI) and (VII) and their pro...  
WO/2014/157636A1
A method for producing isocyanate, said method comprising: a carbamation step for producing an N-substituted carbamate by a carbamation reaction using an organic primary amine, urea and an organic hydroxy compound, and then collecting fi...  
WO/2014/153147A1
Disclosed are compounds of the general formula I and II (as further defined herein) are useful in the production of inhibitors of sphingolipid synthesis the production of sphingolipids. Suitable sphingolipids, include, but not limited to...  
WO/2014/151363A1
Addition- fragmentation agents having the following functional groups: 1) a labile addition- fragmentation group that can cleave and reform to relieve strain, 2) at least one high refractive index group, and 3) at least one ethylenically...  
WO/2014/141578A1
The present invention is a symmetrical hyperbranched silicone-modified polymerizable compound which includes a compound represented by general formula (1). As a result, a positionally and sterically symmetrical hyperbranched silicone-mod...  
WO/2014/142547A1
The present invention relates to a composition for neuroprotection comprising a phenyl carbamate compound and a method for providing neuroprotection therewith. The present invention ensures the enhancement of neuroprotection, such that i...  

Matches 451 - 500 out of 7,756