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JP5307106B2 |
The present invention relates to modafinil polymorphic form VI, methods of preparation thereof, pharmaceutical compositions and methods of therapeutic treatment involving modafinil polymorphic form VI.
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JP5295560B2 |
Compounds of the formula (I): in which R, R1 and R2 are as defined in the description, the use thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, pharmaceutical compositions comprising them, and . processes for the...
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JP2013533219A |
A carbocatalyst for use in oxidation and polymerization reactions includes particles having a carbon and oxygen-containing material, such as catalytically-active graphene oxide and/or catalytically-active graphite oxide. In some cases, t...
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JP5263468B2 |
To provide a method for producing an optically active sulfoxide compound useful as a synthetic intermediate or base material for a physiologically active substance such as a medicine, etc., in a high optical purity. The method for produc...
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JP5254934B2 |
Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The power of Nature and the flexibility of organic synthesis are combined in nucleic acid-templated synthesis....
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JP2013142075A |
To manufacture an amine compound at high purity in a high yield.An alkali metal salt of formula (1) is caused to react with a compound of formula (2) in an aprotic polar solvent. In the formula, X is sulfonyl or carbonyl and Z is halogen.
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JP2013525328A |
Producing 4,4'-dichlorodiphenyl sulfone from monochlorobenzene, comprises (a) purifying monochlorobenzene to obtain monochlorobenzene, (b) coverting the monochlorobenzene obtained in the step (a) to a mixture containing 4,4'-dichlorodiph...
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JP2013521248A |
The invention relates to a method for producing 4-chlorobenzene sulphonic acid from 2-chlorobenzene sulphonic acid and/or 3-chlorobenzene sulphonic acid, comprising the reaction of 2-chlorobenzene sulphonic acid and/or 3-chlorobenzene su...
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JPWO2011093423A1 |
The present invention is characterized in that crystals of the compound represented by the formula (E) -I are precipitated in the presence of an acid to shift the isomerization equilibrium of the compound represented by the formula (Z) -...
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JP5196787B2 |
αβ-Unsaturated sulfoxides of Formula I: are useful as antiproliferative agents including, for example, anticancer agents, and as radioprotective and chemoprotective agents.
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JP5198780B2 |
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JP5192370B2 |
SUMMARY OF THE INVENTION The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulp...
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JP5186910B2 |
There is provided a method for producing a tris(perfluoroalkanesulfonyl)methide acid salt represented by formula [1], including the steps of (a) reacting a methylmagnesium halide represented by formula [2] with a perfluoroalkanesulfonyl ...
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JP2013060385A |
To provide a method for producing in good yield a fluorine-containing alkyl sulfone compound suitably usable for electrolytic solution for an electrochemical device, and to provide electrolytic solution for an electrochemical device cont...
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JP5149199B2 |
The invention relates to a process for selectively controlling the crystallisation mesotrione [2-(4-methylsulphonyl-2-nitrobenzoyl)cyclohexane-1,3-dione] from aqueous solution in which the aqueous mesotrione solution is introduced to a c...
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JP2013014542A |
To provide a highly pure product of, for example, trans-1,2-bis(phenylsulfonyl)ethylene.This invention relates to a reaction of a compound represented by general formula [I] [PhO2S-CR=CRX] [in general formula [I], Ph is a phenyl group wh...
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JP2013014543A |
To provide a method capable of producing, for example, trans-1,2-bis(phenylsulfonyl)ethylene simply at low cost in excellent productivity.This reaction method includes a reaction step A between a compound represented by general formula [...
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JP2013500971A |
Processes useful for the preparation of a Compound of Formula I: Formula (I). Intermediates useful for the preparation of the compound of Formula I, and processes useful for preparing said intermediates are disclosed.
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JP5112583B2 |
Methods of synthesizing pure enantiomers of acylanalides such as Casodex(R) (bicalutamide) and its derivatives utilizing a compound having a ring structure that, when opened, provides a substituent having the structure of Formula I: wher...
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JP5113754B2 |
A process for preparing ester oxazolidine compounds is disclosed. These compounds are useful intermediates in processes for making Florfenicol.
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JP5112074B2 |
The invention is directed at a new process for the preparation of pure enantiomers from the racemate of amidoacetonitrile compounds of formula wherein R1, R2 and R3, independently of each other, signify hydrogen, halogen, nitro, cyano, C...
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JP2012533417A |
A chemical reactor comprises a microwave irradiating apparatus and a chemical reaction apparatus. The microwave irradiating apparatus comprises a microwave generator and a microwave irradiating cavity (3). The chemical reaction apparatus...
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JP5097043B2 |
The invention relates to a sulfur-containing compounds of formula 1, wherein R 2 is S or SO 2 and R 1 , R 3 and R 4 are as defined in the claims, and the preparation thereof. The invention also relates to the uses of the sulfur-containin...
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JPWO2010143578A1 |
An object of the present invention is to provide a method for producing an alkyl sulfone compound easily and safely in a high yield, and an alkyl sulfone compound. The present invention is a method for producing an alkyl sulfone compound...
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JP2012228647A |
To provide continuous crystal purification equipment which has the same efficiency or is better than the conventional continuous crystal purification equipment and which has a wide application range while the structure is simpler and sti...
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JP5064503B2 |
The present invention relates to compounds of formula I wherein R1, R2, R3, R4, R5, X, and n are as defined herein and the dotted line denotes an optional bond and pharmaceutically acceptable acid addition salts thereof. The compounds ar...
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JP5054532B2 |
The present invention relates to compounds having the general formula (I) with the definitions of R 1 -R 6 given below, and/or a salt or ester thereof. Furthermore the invention relates to the use of said compounds as a medicament, prefe...
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JP5044788B2 |
To provide an industrially easily adoptable method for producing a trans-ethylene derivative by which simplicity is high at high speed with high economical efficiency and a small load on environments. The method for producing the trans-e...
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JP5046650B2 |
The invention concerns a compound of the Formula (I), wherein Qa is heteroaryl and is substituted with halogeno; R1 and R2 are hydrogen; and Qb is phenyl or heteroaryl, and Qb may optionally bear 1 or 2 substituents selected from hydroxy...
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JP5042843B2 |
The present invention provides an industrially advantageous process for producing hydrazone derivative represented by the formula (5), which is shown by the following reaction formula.
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JP5041646B2 |
The present invention relates to a procedure for the oxidation of a thioether group to a sulfoxide group, with aqueous sodium percarbonate in the presence of a molybdenum salt as a catalyst. The procedure is of application to oxidize the...
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JP5042422B2 |
Substituted 2-dialkylaminoalkylbiphenyl derivatives, processes for their preparation, pharmaceutical compositions comprising these compounds and methods using these compounds for the preparation of medicaments and for the treatment of di...
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JP5025264B2 |
The invention relates to substituted phenoxyacetic acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.
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JP2012520276A |
There is provided compounds of formula I, wherein Y, ring A, Da, Db, D2, D3, L1, Y1, L2, Y2, L3 and Y3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of ...
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JP5016178B2 |
The present invention relates to compounds of the of the formula I, in which R<1>, R<2>, A and B have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a st...
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JP5005852B2 |
Benzoylcyclohexanediones of the formula (I), process for their preparation and their use as herbicides and plant growth regulators are described.In this formula (I), R11, R2, R3, R4, R5, R6 and R7 are various radicals, L is an alkylene c...
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JP5003239B2 |
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JP4998042B2 |
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JP2012517978A |
The invention relates to the use of compounds of formula I wherein the substituents are described in the description and claims for the treatment of psychoses, dysfunction in memory and learning, schizophrenia, dementia, attention defici...
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JP2012517454A |
The present invention provides phenoxyacetic acid derivatives of Formula (I) for the treatment of CRTH2 related disorders and disease selected from asthma, atopic dermatitis and inflammatory dermatoses.
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JP4982021B2 |
The use of bissulfonamides for producing medicines for the treatment of hyperlipidemia.The invention relates to the use of bissulfonamides and their salts for producing medicines for the treatment of hyperlipidemia.The use of compounds o...
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JP4977607B2 |
Novel optically active phthalamides of the formula (I) in which A, q, R1, R2, E1, E2, X, m, Y, n and Z are as defined in the description, processes for preparing these compounds and their use for controlling pests.
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JP4980309B2 |
The present invention provides a new crystalline form of modafinil and processes for preparing the same.
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JP4969750B2 |
The present invention relates to an NHE-1 selective Na+/H+ antiporter inhibitor N-(4,5-bismethanesulfonyl-2-methylbenzoyl)guanidine, hydrochloride, to its hydrochloride hydrate, and to a process for the preparation.
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JP4960380B2 |
Compounds of formula I wherein X is O or S(═O)n; n is 0, 1 or 2; R1 is optionally substituted alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, cycloalkyl, halocycloalkyl, cycloalkenyl, halocycloalkenyl, phenyl, hetaryl, ph...
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JP4955868B2 |
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JP4951754B2 |
A novel 1-fluoro-1,1-bis(arylsulfonyl)methane is provided which is useful in monofluoromethylation. Also provided is a production method thereof. A method for producing a fluorobis(arylsulfonyl)methane, the method including the steps of:...
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JP4942463B2 |
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JP4942391B2 |
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JP4938035B2 |
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