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WO/2021/122997A1 |
The present invention relates to the field of perfumery. The present invention relates to compounds of formula (I) that are able to provide a long-lasting or substantive odor, in particular floral and/or fruity odor, to the environment. ...
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WO/2021/126543A1 |
A method for forming a polyarylene sulfide with a relatively low content of volatile malodorous compounds is provided. More particularly, such low compound levels may be achieved by subjecting a washed polyarylene sulfide to a heat treat...
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WO/2021/114424A1 |
Provided is a method for preparing a trifluorohydrocarbyl sulfone compound. The preparation method comprises continuously sending a trifluorohydrocarbyl thioether compound, sodium tungstate dihydrate and a hydrogen peroxide solution to a...
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WO/2021/113808A1 |
The present disclosure relates to heterocyclic compounds, pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof. Also described herein are compositions and the use of such compounds in methods of treating dis...
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WO/2021/104503A1 |
Disclosed is a method for preparing β-carbonyl sulfone. The method comprises: by taking an α-carbonyl diazo compound and sodium arylsulfinate as reaction substrates, cheap silver nitrate as an optimal catalyst, 1,10-phenanthroline as a...
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WO/2021/102567A1 |
The synthesis of a range of pentylbezene- 1,3-diol compounds of formula I is disclosed. These compounds bind to cannabinoid 1 and 2 receptors (CB1 and CB2), and are thus presumed to be useful in modulating the activity of such receptors....
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WO/2021/105499A1 |
The present invention relates to N-(4-((4-(3- phenylureido)phenyl)sulfonyl)phenyl)benzolsulfonamide in the polymorphic form ω18.9, characterized by a an x-ray powder diffractogram having the Bragg angles (2θ/CuKα) 10.9, 11.7, 14.6, 15...
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WO/2021/098885A1 |
Provided are α-fluorochalcone derivatives and an application thereof, the derivatives comprising a pharmaceutically acceptable salt thereof. Also provided is an application for the derivatives and the pharmaceutically acceptable salt th...
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WO/2021/091905A1 |
Methods for producing large cannabinoid-loaded liposomes are provided. In one example, these liposomes are large and mostly multilamellar. In another example, the liposomes are a combination of large multilamellar and unilamellar liposomes.
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WO/2021/083209A1 |
Provided are a compound of formula (I') or (I), a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of SSAO, a pharmaceutical composition comprising a compound of...
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WO/2021/079617A1 |
The present invention provides: an amidite compound capable of improving the yield and purity of a polyoligonucleotide; a glycoside compound serving as an intermediate of the amidite compound; and a production method for a polynucleotide...
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WO/2021/069927A1 |
The disclosures herein relate to novel compounds of formula (1): (1) and salts thereof, wherein A, X, R1, R2, R3, R4, R10 and R11 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk o...
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WO/2021/069567A1 |
The present invention relates to novel heteroaryl-triazole compounds of the general formula (I), in which the structural elements X, Y, R1, R2, R3a, R3b, R4 and R5 have the meaning given in the description, to formulations and compositio...
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WO/2021/071372A1 |
The invention relates to an improved process of vitamin K2 derivatives preparation via the alkylation of the menadione-cyclopentadiene adduct.
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WO/2021/067799A1 |
The present application provides methods and compounds of modulating Nrf2 pathway. Methods for treating cancer and neurodegenerative conditions are also provided.
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WO/2021/060517A1 |
The present invention provides a novel method for producing a derivative of an organic substance that contains one or more groups selected from the group consisting of a sulfanyl group, a selanyl group and a sulfino group. A method for p...
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WO/2021/037683A1 |
The invention relates to a process for purifying 4,4'-dichlorodiphenyl sulfone comprising: (a) providing a suspension comprising particulate 4,4'-dichlorodiphenyl sulfone in carboxylic acid, (b) carrying out a solid-liquid separation of ...
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WO/2021/037677A1 |
The invention relates to a process for producing 4,4'-dichlorodiphenyl sulfone comprising reacting a solution comprising 4,4'-dichlorodiphenyl sulfoxide and at least one linear C6-C10 carboxylic acid as solvent with an oxidizing agent to...
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WO/2021/037672A1 |
The invention relates to a process for producing 4,4'-dichlorodiphenyl sulfone, comprising: (a) reacting 4,4'-dichlorodiphenyl sulfoxide and an oxidizing agent in at least one carboxylic acid as solvent to obtain a reaction mixture compr...
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WO/2021/037675A1 |
The invention relates to a process for producing 4,4'-dichlorodiphenyl sulfone, comprising: (I) reacting thionyl chloride, chlorobenzene and aluminum chloride forming an intermediate reaction product and hydrogen chloride; (II) mixing aq...
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WO/2021/037682A1 |
The invention relates to a process for purifying crude 4,4'-dichlorodiphenyl sulfone comprising: (a) dissolving the crude 4,4'-dichlorodiphenyl sulfone which may contain water in an organic solvent in which 4,4'-dichlorodiphenyl sulfone ...
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WO/2021/036845A1 |
Provided is a substituted benzoyl compound and an application thereof; specifically, provided is a compound represented by formula (I), a preparation method therefor and a use thereof as an herbicide. Q is optionally substituted oxocyclo...
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WO/2021/037680A1 |
The invention relates to a process for obtaining 4,4'-dichlorodiphenyl sulfone from an organic mixture comprising 4,4'-dichlorodiphenyl sulfone and a linear C6 to C10 carboxylic acid as organic solvent, comprising: (a) cooling the organi...
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WO/2021/037797A1 |
The invention relates to crystals (C) consisting of at least 98 % by weight of 4,4'- dichlorodiphenylsulfone, 0 to 2 % by weight of impurities and 0 to 2 % by weight of at least one solvent (c). Moreover, the present invention relates to...
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WO/2021/020429A1 |
The present invention provides a compound represented by formula (I) or a pharmaceutically acceptable salt thereof which has the effect of antagonizing the LPA1 receptor.
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WO/2021/012014A1 |
The present invention relates to methods for preparing a variety of difluorohaloallylamine derivatives. The present invention also relates to novel difluorohaloallylamine derivatives that are capable of inhibiting certain amine oxidase e...
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WO/2021/007840A1 |
Provided is a carbamate-substituted styryl sulfone compound, a preparation method, and an application thereof. The carbamate-substituted styryl sulfone compound has a structure represented by general formula I. The carbamate-substituted ...
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WO/2021/007663A1 |
This disclosure relates to cannabinoid derivatives of formula (I), pharmaceutical compositions comprising them, and methods of using the cannabinoid derivatives in treating or preventing a diseases associated with a cannabinoid receptor ...
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WO/2021/007478A1 |
Provided herein are sulfone compounds, for example, a compound of Formula A, or an enantiomer, a mixture of enantiomers, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotopic variant there...
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WO/2020/257573A1 |
The invention provides crystalline salt and cocrystal forms of bempedoic acid. Also provided are compositions and pharmaceutical materials including a crystalline salt or cocrystal form of bempedoic acid as well as methods of treating va...
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WO/2020/257571A1 |
The invention provides methods of preparing 8-hy droxy-2,2, 14,14- tetramethylpentadecanedioic acid and methods of making a pharmaceutical material comprising a purified amount of 8-hy droxy-2,2, 14, 14-tetramethylpentadecanedioic acid. ...
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WO/2020/257093A1 |
The present invention is directed to a method for treating Asthma. The method comprises administering to a subject in need thereof 3-methanesulfonylpropionitrile (dapansutrile), or a pharmaceutically acceptable solvate thereof, in an eff...
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WO/2020/251012A1 |
Provided is are an agricultural and horticultural agent, in particular a compound which is useful as the active ingredient of an agricultural and horticultural pest control agent, a mite control agent, a nematode control agent or a disea...
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WO/2020/239568A1 |
There is disclosed a salt of Formula III, a method for manufacturing thereof as well as uses thereof. ( Formula III ), wherein X is H or OH, Y is H or a cation selected from the group consisting of Li, Na and K, is a single bond or a dou...
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WO/2020/238779A1 |
The present invention relates to a method for synthesizing florfenicol. The method comprises the steps of: using sulfuryl fluoride as a fluorinating reagent to fluorinate compound I to obtain a product, and then performing a ring opening...
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WO/2020/229685A1 |
A pharmaceutical composition or combination product comprising certain polyunsaturated long-chain ketones in combination with certain protein kinase inhibitors, in particular phosphatidylinositol-4,5-bisphosphate 3-kinase inhibitors (PI3...
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WO/2020/221960A1 |
The present invention relates to a stable formulation comprising at least one organic solvent selected from a group consisting of aliphatic esters and cyclic esters, and a compound of Formula (I).
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WO/2020/212543A1 |
The present invention relates to novel ophthalmic devices comprising polymerized compounds comprising a photoactive unit, said polymerized compounds, and special monomer compounds being particularly suitable for compositions and ophthalm...
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WO/2020/207929A1 |
The invention relates to a process for working up a composition comprising solid 4,4'- dichlorodiphenyl sulfoxide and a solvent, wherein the amount of solvent in the composition is in the range between 5 and 25 wt% based on the total mas...
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WO/2020/186632A1 |
The present application relates to a benzidine compound and an application thereof, the benzidine compound having the structure as shown in formula I below. Further provided in the present application are a pharmaceutically acceptable sa...
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WO/2020/187795A1 |
The invention relates to an anionic surfactant of general formula (I) or general formula (II) or mixtures thereof, in which R represents hydrogen or a linear or branched alkyl, alkenyl, alkyl-aryl or alkenyl-aryl group with 5 to 25 C ato...
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WO/2020/161225A1 |
The invention relates to a process for purifying 4,4'-dichlorodiphenyl sulfoxide comprising: (a) providing a suspension comprising particulate 4,4'-dichlorodiphenyl sulfoxide in monochlorobenzene, (b) solid-liquid separation of the suspe...
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WO/2020/161228A1 |
The invention relates to a process for producing 4,4'-dichlorodiphenyl sulfoxide comprising: (I) reacting thionyl chloride, chlorobenzene and aluminum chloride in a molar ratio of thionyl chloride : chlorobenzene : aluminum chloride of 1...
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WO/2020/161226A1 |
The invention relates to a process for obtaining 4,4'-dichlorodiphenyl sulfoxide from a liquid mixture comprising 4,4'-dichlorodiphenyl sulfoxide and a solvent, comprising: (a) cooling the liquid mixture to a temperature below the satura...
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WO/2020/142764A1 |
The present application relates to new HtrA inhibitors and use thereof. Additionally, the present application also relates to new peptides for inhibiting CagA and use thereof.
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WO/2020/135000A1 |
Disclosed is a preparation method for 3-phenyl-L-serine or derivatives thereof, comprising the following steps: a. obtaining 3-phenyl-L-serine or derivatives thereof on the basis of the reaction formula represented by Formula I, wherein ...
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WO/2020/127960A1 |
The present invention relates to disubstituted alkyne derivatives. These compounds are useful for the prevention and/or treatment of several medical conditions including hyperproliferative disorders and diseases.
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WO/2020/127675A1 |
Described are colour developers of formula (I) Ar1-SO2-NH-C6H4-SO2-C6H4-NH-CO-NH-Ar2 (I), a heat-sensitive recording material, comprising a base substrate and also a heat-sensitive, colour-forming layer comprising at least one colour for...
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WO/2020/102901A1 |
Provided herein are synthetic compounds useful for inhibiting bacterial growth and uses thereof. Also provided are pharmaceutical compositions. The compounds and pharmaceutical compositions are useful for inhibiting growth of a bacterium...
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WO/2020/094917A1 |
The present invention relates to a process for the preparation of arylsulfonylpro- penenitriles. The reaction starting from arylsulfonyl halides is catalyzed by a cat- alyst compound comprising a transition metal. The process is scalable...
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