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JP5037337B2 |
Novel cyclohexyl-1,4-diamine compounds corresponding to formula I, processes for the production thereof, pharmaceutical compositions containing these compounds, methods of producing pharmaceutical compositions including these compounds a...
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JP2012520887A |
The present invention relates to novel heterocyclic compounds as diacylglycerol acyltransferase ("DGAT") inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventin...
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JP5016666B2 |
The invention is concerned with novel diazepan derivatives of formula (I) wherein A, X, R3, R4, R5, R6, R8, R9, R10, R11, R12, R13, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts ...
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JP5021488B2 |
The present invention is related to derivatives of Formula (I) and use thereof in particular for the treatment and/or prophylaxis of autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, cancer...
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JP5009785B2 |
Urea derivatives represented by the following general formula (I) : which have an agonism of V2 receptor, are useful as agents for the treatment or prevention of diabetes insipidus, nocturia, nocturnal enuresis, overactive bladder or the...
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JP5004590B2 |
A compound, or its salt or a solvate thereof, having the formula (Va): for producing a 7-membered heterocyclic compound, or its salt or a solvate thereof having formula (I): the compound of formula (I) having a chymase inhibitory action ...
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JP5001372B2 |
The invention relates to 4-oxo-2,3,4,5-tetrahydro-benzo [b][1,4]diazepines of formula I wherein R1, R2, R3 and R4 are as defined in the description and claims, which are gamma-secretase inhibitors and which may be useful in the treatment...
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JP2012517997A |
The present invention relates to a compound represented by a formula (I): wherein R1 represents a halogen atom or the like; R2 represents a hydrogen atom or the like; R3 and R4 each independently represents lower alkyl; R5 represents phe...
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JP2012144533A |
To provide an identification method of a compound useful as an anti-infective agent that decreases resistance, virulence or growth of microbes.A microbial cell including (1) a selectable marker under the control of a transcription factor...
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JP4991527B2 |
The present invention provides analogs and derivatives of thalidomide which inhibit cancer and angiogenesis. The present invention further provides compounds which disrupt microtubule polymerization. The present further provides methods ...
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JP4980358B2 |
Use of a benzodiazepine of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in treating or preventing a hepatitis C infection, wherein: —R1 represents C1-6 alkyl, aryl or heteroaryl...
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JP2012515713A |
The present invention relates to a compound represented by the formula (I): wherein R1 represents a hydrogen atom or the like; R2 represents lower alkyl or the like; R3 and R4 represent lower alkyl or the like; R5 represents phenyl or th...
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JP2012515202A |
The invention relates to methods for diagnosis and treatment of autism spectrum disorders, particularly for autism spectrum disorders characterized by increased head size (circumference) and deficits in social behavior.
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JP4967401B2 |
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JP2012121898A |
To provide a pharmaceutical used for prevention or therapy of various types of diseases that involve the kimase.The pharmaceutical is a compound containing a 7-membered heterocyclic compound represented by formula (I). The compound is, f...
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JP2012514655A |
Fluorinated compounds and methods of making fluorinated compounds are described herein.
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JP4963671B2 |
The present invention is directed to novel substituted aminocyclohexanes which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DPP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipept...
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JP4956426B2 |
The present invention relates to a novel class of paramagnetic ion-based contrast agents of formula (I), wherein a chelating backbone moiety is highly functionalized by the presence of one or more polyhydroxylated chain, that show a phar...
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JP4957250B2 |
To provide a pharmaceutical agent or an antitumor agent useful for the treatment and/or prevention of gastrointestinal cancer, leukemia, pituitary tumor, small cell lung cancer, thyroid cancer, and neuroastrocytoma. The antitumor agent c...
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JP2012111775A |
To provide a method for improving pharmacokinetics of drugs which are metabolized by cytochrome P450 monooxygenases.The method comprises administering a combination of: the drugs which are metabolized by cytochrome P450 monooxygenases or...
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JP2012107022A |
To provide new compounds, methods for their discovery, and their therapeutic use.There are provided benzodiazepine derivatives and methods for using benzodiazepine derivatives as therapeutic agents to treat a number of conditions associa...
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JP4942915B2 |
Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit HIV protease activity and/or are useful therapeutically for th...
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JP4943858B2 |
A present invention provides aromatic amide derivatives which have an agonism of V2 receptor, are useful as agents for the treatment or prevention of diabetes insipidus, nocturia, nocturnal enuresis, overactive bladder or the like, and a...
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JP4933730B2 |
Methods for identifying compound useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. In one embodiment, the method comprises contacting a microbial cell comprising: 1) a selectable marker un...
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JP2012087082A |
To provide a pharmaceutical composition which is useful as a pharmaceutical composition for preventing or treating diseases caused by thrombus or embolus.The pharmaceutical composition comprises: N-(3-hydroxy-2-{[4-(4-methyl-1,4-diazepam...
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JP2012087053A |
To provide a P2X4 receptor antagonist.A preventive or therapeutic agent of neurogenic pain contains a diazepinedione derivative expressed by 5-(3-hydroxyphenyl)-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5
H)-dione, etc. or a pharmacological...
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JP2012087069A |
To provide a method for producing a 2,3,4,5-tetrahydro-1H-1,4-diazepine-2,3-dicarboxylic acid diester derivative condensed at the [6,7] sites with an aromatic ring, and to provide the derivative.The method for producing a 2,3,4,5-tetrahy...
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JP4929500B2 |
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JP4926362B2 |
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JP4919599B2 |
the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n represents an integer being 1 or 2; R1 and R2 each independently represents hydrogen C1-4alkyl, NR9R10, C1-4alky...
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JP4913588B2 |
This invention relates to a novel farnesylated dibenzodiazepinone, named ECO-04601, its pharmaceutically acceptable salts and derivatives, and to methods for obtaining such compounds. One method of obtaining the ECO-04601 compound is by ...
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JP4901065B2 |
The invention is to provide a thermoplastic resin composition rich in heat resistance, oil resistance, and thermal aging resistance and excellent in tensile elongation characteristics, by adding a specific partially hydrogenated block co...
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JP4895416B2 |
The present invention is aimed at a process for controlled polymerization of ethylenically unsaturated monomers in the presence of heterocyclic sterically hindered alkoxyamine compounds. The intermediate N-oxyl derivatives, a composition...
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JP2012505185A |
The invention relates to the use of and mainly novel compounds of the formula I wherein the moieties are as defined in the description, which are useful as farnesyl pyrophosphate synthase modulators and e.g. in the treatment of prolifera...
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JP4866738B2 |
Cyclic carbonate and urea derivatives (I) and (II) are new. Cyclic carbonate and urea derivatives of formulae (I) and (II) are new. [Image] R : 1-12C alkylene; X : -CONHR 1>; R 1>1-30C alkyl (optionally substituted by halo, hydroxy, 1-6C...
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JP4857748B2 |
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JP4847320B2 |
A method of evaluating memory/ learning functions with the use of a model with glutamic acid N-methyl-D-aspartate (NMDA) type receptor hypofunction as an animal model for schizophrenia and with the use of reference memory task, wherein t...
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JP4824567B2 |
The present invention relates to novel diazepanyl derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
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JP4816814B2 |
The present invention provides a Michael addition reaction product between a specified compound having a group which functions as a Michael donor and a monomer or polymer having a group which functions as a Michael acceptor, a photoiniti...
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JP4787234B2 |
Carbamoylalkyl 1-((hetero)aryl-substituted alkyl)-piperazine (or homopiperazine) 4-carboxylates (I) are new. Piperazine or homopiperazine derivatives of formula (I) and their acid addition salts, hydrates and solvates are new. n : 1 or 2...
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JP2011525478A |
The present invention relates to piperazine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatme...
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JP4776778B2 |
Arylpiperazines of formula (I) useful as metalloproteinase inhibitors, especially as inhibitors of MMP 13
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JP4769562B2 |
It has now been found that compounds of the present invention as described in Benzodiazepine derivatives of Formula (I) containing a carboxylic ester moiety and thereby capable of being inactivated by nonspecific tissue esterases in an o...
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JP4769760B2 |
It has now been found that compounds of the present invention as described in Benzodiazepine derivatives of Formula (I) containing a carboxylic ester moiety and thereby capable of being inactivated by nonspecific tissue esterases in an o...
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JP4769759B2 |
It has now been found that compounds of the present invention as described in Benzodiazepine derivatives of Formula (I) containing a carboxylic ester moiety and thereby capable of being inactivated by nonspecific tissue esterases in an o...
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JP4752011B2 |
The invention relates to new 8-chloro-2,3-benzodiazepine derivatives of the general formula (I), wherein R stands for a lower alkyl group or a group of the general formula —NH—R′, wherein R′ stands for a lower alkyl or a lower cy...
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JP4731114B2 |
The present invention relates to substituted sulfonamide compounds of the general formula (I), wherein P is sulfonamide or amide-substituted sulfonic acid, which compounds are potentially useful for the prophylaxis and treatment of medic...
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JP4725946B2 |
This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing th...
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JP2011519354A |
The invention relates to novel amide derivatives that are positive allosteric modulators of neuronal nicotinic receptors, compositions comprising the same, processes for preparing such compounds, and methods for using such compounds and ...
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JP4719466B2 |
Benzodiazepine derivative of formula (I), and pharmaceutically acceptable salts thereof, are found to be active against RSV Formula (I) Wherein: —R1 represents C1-6 alkyl, aryl or heteroaryl; —R2 represents hydrogen or C1-6 alkyl; -e...
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