Heterocyclic Compounds

Matches 751 - 800 out of 2,716	< 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 >

Document	Document Title
WO/1996/029329A1	CYCLIC UREA HIV PROTEASE INHIBITORS This invention relates to substituted cyclic ureas and derivatives thereof, including compounds of formula (II), said compounds being useful as inhibitors of HIV protease. The present invention also relates to pharmaceutical compositions...
WO/1996/029316A1	NEW SULFONE ESTER ANALOGUES OF iso-CLOZAPINE AND RELATED STRUCTURES: ATYPICAL NEUROLEPTICS A compound of formula (I), or pharmaceutically acceptable acid addition salts thereof, wherein R1 is H, (C1-C8) alkyl or haloalkyl or hydroxyalkyl, alkenyl, alkynyl, cyclopropylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl; R2 is H...
WO/1996/026190A1	INTEGRIN RECEPTOR ANTAGONISTS Integrin receptor antagonists of formula (I) are disclosed, wherein: X-X' is NR1-CH, NC(O)R3-CH, N=C, CR1=C, CHR1-CH, O-CH or S-CH; R1 is H, C1-6alkyl, C3-7cycloalkyl-C0-6alkyl or ArC0-6alkyl; R2 is (CH2)nCO2R; R3 is H, C1-6alkyl, Ar-C0-...
WO/1996/022282A1	TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS Tricyclic compound of general formula (I) as defined herein which exhibit antagonist activity at V1 and/or V2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characteri...
WO/1996/018629A1	5-HT2 RECEPTOR LIGANDS Described herein are 5-HT2 receptor-selective compounds of formula (I), wherein: A and B are independently selected, optionally substituted, saturated or unsaturated 5- or 6-membered, homo- or heterocyclic rings; X1 is selected from O, S...
WO/1996/018622A1	N-METHYL PIPERAZINE COMPOUNDS HAVING DOPAMINE RECEPTOR AFFINITY Described herein are D4 receptor-selective compounds of general formula (I) wherein X1 is selected from CH2, NH, O and S; X2-- is selected from CH=, CH2-, and N=; R1 to R8 are each independently selected from H, C1-4alkyl, halo, cyano, n...
WO/1996/017833A1	BICYCLIC FIBRINOGEN ANTAGONISTS This invention relates to compounds of formula (I) which are effective for inhibiting platelet aggregation, pharmaceutical compositions for effecting such activity, and a method for inhibiting platelet aggregation.
WO/1996/014844A1	CYCLIC AMIDINE ANALOGS AS INHIBITORS OF NITRIC OXIDE SYNTHASE Disclosed herein are the heterocyclic compounds and pharmaceutically acceptable salts thereof which have been found to be useful in the treatment of nitric oxide synthase mediated diseases and disorders.
WO/1996/013488A1	NOVEL BENZODIAZEPINONE DERIVATIVE AND MEDICINAL COMPOSITION THEREOF A benzodiazepinone derivative represented by general formula (I) or a salt thereof, having a selective muscarine M2 receptor antagonism and being useful as a preventive or remedy for various diseases wherein muscarine M2 receptors partic...
WO/1996/011691A1	USE OF 1,5-BENZODIAZEPINE DERIVATIVES FOR THE CONTROL OF GASTRIC EMPTYING IN PATIENTS WITH NON-INSULIN DEPENDENT DIABETES MELLITUS The use of a compound of formula (1) or a physiologically salt thereof in the manufacture of a therapeutic agent for the treatment of early non-insulin dependent diabetic conditions.
WO/1996/011940A1	ACYL AMINO ACETAMIDE DERIVATIVES WITH AGONIST ACTIVITY FOR CCK-A RECEPTORS A CCK-A agonist of the general formula (I) R1R2NCOCH2N(R3)COR4 and physiologically acceptable salts thereof wherein, R1 is independently C3-6alkyl, C3-6cycloalkyl, C3-6alkenyl, phenyl, -(CH2)pCN or -(CH2)pCOO(C1-4alkyl) and R2 is indepen...
WO/1996/011701A1	ENTERIC COATED COMPOSITIONS OF 1,5-BENZODIAZEPINE DERIVATIVES HAVING CCK ANTAGONISTIC OR AGONISTIC ACTIVITY A pharmaceutical formulation in solid dosage form for oral administration which comprises a compound of general formula (I) or a physiologically salt thereof together with one or more pharmaceutically acceptable carriers wherein the form...
WO/1996/009297A1	COMPOSITIONS AND METHODS FOR TREATING MAST-CELL INFLAMMATORY CONDITION Novel compounds, compositions and methods effective for the prevention and treatment of mast-cell mediated inflammatory disorders are described. The compounds, compositions and methods are effective for the prevention and treatment of in...
WO/1996/005839A1	2,3-DIHYDRO-1-(2,2,2-TRIFLUOROETHYL)-2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPINES This invention is concerned with novel compounds represented by structural formula (I), where X and Y are independently hydrogen, chloro, fluoro, bromo, iodo, or trifluoromethyl and n is 0, 1 or 2; R is hydrogen, fluoro, chloro, bromo, i...
WO/1996/005827A1	N-2,3-DIHYDRO-1-(2-PROPYL)-2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPINES This invention is concerned with novel compounds represented by structural formula (I), where R1 is formula (II) or (III); X and Y are independently hydrogen, fluoro, chloro, bromo, iodo, or trifluoromethyl; n is 0, 1 or 2; and R2 is hyd...
WO/1996/006087A1	BICYCLIC COMPOUNDS This invention relates to compounds of formula (I) or a pharmaceutically acceptable salt thereof, which are effective for inhibiting platelet aggregation and bone resorption, pharmaceutical compositions for effecting such activity, and a...
WO/1996/005178A1	SYNTHESIS OF BENZODIAZEPINES A general method is provided for the synthesis of substituted 2,3-dihydro-5-phenyl-1H-1,4-benzodiazepines by the reaction of bis-triflated-2,5-dihydroxy benzophenones with 1,2-bisaminoethanes, followed by displacement of the 7-trifloxy g...
WO/1996/004254A2	BENZODIAZEPINE DERIVATIVES Benzodiazepine derivatives of formula (I) wherein R1 is aryl which may have one or more suitable substituent(s), R2 is C3-C8 cycloalkyl which may have one or more suitable substituent(s), A is lower alkylene, R3 is a heterocyclic group s...
WO/1996/004288A1	GLYCINE RECEPTOR ANTAGONIST PHARMACOPHORE Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotropic lateral sclerosis, Huntingto...
WO/1996/000730A1	VITRONECTIN RECEPTOR ANTAGONISTS Compounds are disclosed which are vitronectin receptor antagonists useful in the treatment of osteoporosis. These compounds comprise a fibrinogen receptor antagonist template linked to a heterocyclic moiety.
WO/1996/000728A1	PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF CYCLIC UREA HIV PROTEASE INHIBITORS This invention relates to novel compounds and derivatives thereof containing a trioxepane protected diol in addition to a hydrazone, hydrazine, amine, or cyclic urea moiety; methods for the preparation of said compounds; and the use of s...
WO/1996/000708A1	METHOD FOR PREPARING ALKYLATING AGENTS AND THEIR USE FOR ALKYLATING CYCLIC UREAS This invention relates to methods for preparing alkylating agents and use of the agents prepared. In particular, this invention relates to preparation methods for hydroxy halide and organooxy halide alkylating agents and their use for al...
WO/1996/000574A1	VITRONECTIN RECEPTOR ANTAGONISTS Compounds of formula (I) are disclosed which are inhibitors of the vitronectin receptor, wherein X-X' is NR1-CH, NC(O)R3-CH, N=C, CR1=C, CHR1-CH, O-CH or S-CH; R1 is H, C1-6alkyl or benzyl; R2 is (CH2)nCO2H; R3 is H, C1-6alkyl, Ar-C0-6al...
WO/1995/034540A1	BENZOHETEROCYCLIC DERIVATIVES USEFUL AS VASOPRESSIN OR OXYTOCIN MODULATORS A benzoheterocyclic derivative of formula (1) and pharmaceutically acceptable salts thereof, which show excellent anti-vasopressin activity, vasopressin agonistic activity and oxytocin antagonistic activity, and are useful as a vasopress...
WO/1995/033464A2	RETROVIRAL PROTEASE INHIBITOR COMBINATIONS The present invention is directed to a method for the treatment of mammalian retrovirus infections, such as HIV, using combinations of retroviral protease inhibitors which are effective in preventing the replication of the retroviruses i...
WO/1995/032191A1	INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the encogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compou...
WO/1995/029900A1	CONDENSED HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE AS GnRH ANTAGONISTS Compounds represented by formula (I), wherein ring A is benzene; Ar is aromatic group; R1, R2 and R3 each stands for H, acyl, hydrocarbon or heterocyclic, or R2 and R3, taken together, may form non-aromatic cyclic hydrocarbon; X is methy...
WO/1995/028640A1	COMPLEX COMBINATORIAL CHEMICAL LIBRARIES ENCODED WITH TAGS Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produc...
WO/1995/028419A1	CCK OR GASTRIN MODULATING 5-HETEROCYCLIC-1,5-BENZODIAZEPINES Compounds of general formula (I) and physiologically salts thereof, processes for their preparation and their use as modulators of the effects of gastrin and CCK.
WO/1995/028399A1	A METHOD OF INDUCING CHOLECYSTOKININ AGONIST ACTIVITY USING 1,4-BENZODIAZEPINE COMPOUNDS A method of inducing a Cholescystokinin-A receptor agonist response in a mammal by administering a compound of formula (I), where R1 is C1-C6alkyl, C3-6cycloalkyl, phenyl, or substituted phenyl; R2 is C3-6alkyl, C3-6cycloalkyl, C3-6alken...
WO/1995/028391A1	CCK OR GASTRIN MODULATING 1,5 BENZODIAZEPINES DERIVATIVES 1,5 Benzodiazepine compounds of formula (I), where R1 is selected from C1-C6alkyl, C3-C6cycloalkyl, phenyl, or substituted phenyl; R2 is selected from C3-C6alkyl, C3-C6cycloalkyl, C3-C6alkenyl, benzyl, phenylC1-C3alkyl or substituted phe...
WO/1995/021818A1	NOVEL PROCESS FOR PREPARATION OF CLONIDINE DERIVATIVES A novel process preparing clonidine derivatives has been discovered which is shorter, less expensive and safer than previously known methods. A new thiourea complex of formula (I) wherein: Ar is a phenyl or naphthyl and unsubstituted or ...
WO/1995/021174A1	PHENYLIMINO-THIADIAZABICYCLOALKANE DERIVATIVES, PROCESSES AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS HERBICIDES Compounds of formula (I): wherein R is C1-C6alkyl, C1-C6haloalkyl, C3-C6alkenyl, C3-C6alkynyl, C1-C4alkoxy or C3-C6cycloalkyl; R1 is halogen; R2 and R3 are each independently of the other C1-C4alkyl; R4 is halogen or a group of the formu...
WO/1995/018099A1	AMINOCARBOXYLIC ACID AMIDES, PROCESS FOR PREPARING THE SAME AND THEIR USE AS ANTI-ARRHYTHMIC AGENTS New compounds represent anti-arrhythmic agents, in particular of class III, and because of their large therapeutic spectrum may be used for treating heart rhythm disturbances. The new compounds have the formula (I), in which R1, R2, R3, ...
WO/1995/018104A1	NOVEL BENZAMIDE DERIVATIVE AND MEDICINAL COMPOSITION CONTAINING THE SAME A novel benzamide derivative represented by general formula (I), or a salt, hydrate or solvate thereof. The compound is useful as a 5-HT4 receptor agonist for preventing and treating central nervous system diseases such as schizophrenia,...
WO/1995/018110A1	NOVEL BENZODIAZEPINE DERIVATIVE A benzodiazepine derivative represented by general formula (I) and a pharmaceutically acceptable salt thereof, wherein R1 represents a single bond, -CH2-, -CH2O-, -OCH2-, -SCH2- or (a); R2 represents lower alkyl, -COOR5, -CONH(CH2)nCOOR5...
WO/1995/017400A1	N-HETEROBICYCLYL-PIPERAZINYL OR-PIPERADINYL TRICYCLIC DERIVATIVES USEFUL AS DOPAMINE RECEPTOR LIGANDS Described herein are D4 receptor-selective compounds of general formula (I) wherein A and B are independently selected, optionally substituted, saturated or unsaturated 5- or 6-membered, homo- or heterocyclic rings; X1 is selected from C...
WO/1995/015963A1	BICYCLENE DERIVATIVES, THEIR PRODUCTION AND USE The description relates to bicyclene derivatives of formula (I) in which A, B, D, E, G, K, L, R1, R2, Z1 and Z2 have the meanings given in the description, and their production. These compounds are suitable for treating diseases.
WO/1995/014473A1	ANTIARRHYTHMIC BENZODIAZEPINES Benzodiazepine derivatives with an amide or urea function in the 3-position are useful in the treatment of arrhythmia. The compounds have structural formula (I).
WO/1995/014676A1	3-ACYLAMINOBENZODIAZEPINES 3-Acylamino-5-Aminobenzo[1,5] diazepines are useful in the treatment of arrhythmia. The compounds have structural formulae (I) and (II).
WO/1995/014471A1	ANTIARRHYTHMIC BENZODIAZEPINES Benzo-(1,5)-diazepine derivatives with an amide or urea function in the 3-position are useful in the treatment of arrhythmia. The compounds have structural formulae (I) and (II).
WO/1995/014470A1	METHODS OF TREATING CARDIAC ARRHYTHMIA Benzodiazepine analogs have been found to be useful in treating cardiac abnormalities.
WO/1995/007269A1	POLAR-SUBSTITUTED HYDROCARBONS The invention relates to retroviral protease inhibitors of the general formula (I): W-(A)n-B-(A)m-V where W, A, B, A, V, n and m are as defined herein, including related prodrugs of general formula (I) comprising a solubilising group w...
WO/1995/006041A1	3-PHENYLUREIDO-1,4-BENZODIAZEPINES USEFUL AS SELECTIVE CCK-B ANTAGONISTS A benzodiazepine derivative of formula (I), or a pharmaceutically acceptable salt thereof, wherein (a) R1 is selected from alkyl or cycloalkyl groups, (b) R2 is a tertiary cyclic amino substituent of structure (II), (III) or (IV), in whi...
WO/1995/003830A2	IMPROVEMENTS RELATING TO PRODRUGS The present invention provides a prodrug of the general formula FTLi-(PRT)m, where FTLi is a ras inhibitor such as a farnesyltransferase inhibitor compound and PRT represents m protecting groups capable of being cleaved from the ras inhi...
WO/1995/003279A1	SULFONAMIDE AND SULFONIC ESTER DERIVATIVES EACH HAVING TRICYCLIC HETERO RING Novel antitumor sulfonamide and sulfonic ester derivatives each having a tricyclic hetero ring, represented by general formula (I), and a process for producing the same, wherein G represents a 5- or 6-membered aromatic ring; L represents...
WO/1995/003285A1	1,5-BENZODIAZEPINE DERIVATIVES USEFUL AS CCK OR GASTRIN ANTAGONISTS Compounds of formula (I) wherein R1 represents a phenyl, C3-7cycloalkyl, c7-11 bridgedcycloalkyl or C1-6alkyl group which alkyl group may be substituted by a hydroxy, phenyl, C1-6alkoxycarbonyl, C3-7cycloalkyl, or C7-11 bridgedcycloalkyl...
WO/1995/003284A1	1,5-BENZODIAZEPINE DERIVATIVES USEFUL AS CCK OR GASTRIN ANTAGONISTS Compounds of formula (I) wherein R1 represents a phenyl, C3-7cycloalkyl, C7-11 bridgedcycloalkyl or C1-6alkyl group which alkyl group may be substituted by a hydroxy, phenyl, C1-6alkoxycarbonyl, C3-7cycloalkyl, or C7-11 bridgedcycloalkyl...
WO/1995/001964A1	NOVEL CRYSTAL OF BENZODIAZEPINE DERIVATIVE A type B crystal of (R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo-5-phenyl-1H-1 ,4-benzodiazepin-3-yl]-3-(3-tolyl)urea. It is produced by conducting recrystallization in a solvent mixture composed of 5 parts by volume of alcohol and at ...
WO/1995/000521A1	HERBICIDAL THIADIAZABICYCLODECANES Thiadiazabicyclodecanes of formula (I) wherein, Z is oxygen or sulfur; R is an optional substituent and W is an optionally condensed or substituted phenyl radical and the salts, complexes and stereisomers thereof, have good selective pre...

Matches 751 - 800 out of 2,716	< 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 >