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Title:
NEW FO-6979-M0 SUBSTANCE, FO-6979-M1 SUBSTANCE, FO-6979-M2 SUBSTANCE, FO-6979-M3 SUBSTANCE AND FO-6979-M4 SUBSTANCE AND METHOD FOR PRODUCING THE SAME
Document Type and Number:
Japanese Patent JP2002275194
Kind Code:
A
Abstract:

To provide FO-6979-M0 substance, FO-6979-M1 substance, FO-6979-M2 substance, FO-6979-M3 substance and FO-6979-M4 substance having an inhibitory activity for acyl-coenzyme A(acyl-CoA) cholesterol acyltransferase and a method for producing the substances.

A microorganism having an ability to produce the FO-6979-M0 substance, FO-6979-M1 substance, FO-69179-M2 substance, FO-6979-M3 substance and FO-6979-M4 substance is cultured in a culture medium to accumulate the FO-6979-M0 substance, FO-6979-M1 substance, FO-6979-M2 substance, FO-6979-M3 substance and FO-6979-M4 substance in a culture solution and the resultant FO-6979-M0 substance, FO-6979-M1 substance, FO-6979-M2 substance, FO-6979-M3 substance and FO-6979-M4 substance are then collected from the culture solution. Since the substances have low toxicity and specifically inhibit the acyl-CoA cholesterol acyltransferase, the substances are useful for prophylaxis and treatment of diseases caused by human cholesterol accumulation.


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Inventors:
OMURA SATOSHI
KODA HIROSHI
Application Number:
JP2001080388A
Publication Date:
September 25, 2002
Filing Date:
March 21, 2001
Export Citation:
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Assignee:
KITASATO GAKUEN
JAPAN SOC PROMOTION MACH IND
International Classes:
C12N9/99; A61K31/395; A61K38/00; A61K38/55; A61P3/06; A61P9/10; C07D273/00; C07K5/083; C07K5/087; C07K19/00; C12N1/14; C12P17/14; C12P21/02; C12R1/645; (IPC1-7): C07K5/083; A61K31/395; A61K38/00; A61K38/55; A61P3/06; A61P9/10; C07K5/087; C12N1/14; C12P21/02
Attorney, Agent or Firm:
Kazunori Kobayashi



 
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