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JP5595373B2 |
The present invention provides a method for producing sucralose from a feed stream including a sucrose-6-acylate in a reaction vehicle. The method includes: (i) reacting the sucrose-6-acylate with a chlorinating agent in order to chlorin...
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JP5586683B2 |
A method of forming a sucrose-6-ester includes in sequence the steps of: a) contacting sucrose with a organotin-based acylation promoter in a solvent in the presence of a base selected from amines and basic alkali metal salts; b) removin...
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JP5583027B2 |
The present invention provides a method for producing sucralose from a feed stream resulting from the chlorination of a sucrose-6-acylate in a reaction vehicle. The feed stream includes a sucralose-6-acylate, the reaction vehicle, water,...
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JP5581265B2 |
A phospholipid conjugate according to the general formula (I) or according to the general formula (II) for use in the treatment or prevention of a disorder selected from skin hypersensitivity, respiratory disease, eye disorder, and infla...
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JP5569877B2 |
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JP5564838B2 |
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JP5557243B2 |
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JP5555230B2 |
The invention relates to the compositions of synthetic oligo-²-(16)-2-amino-2-deoxy-D-glucopyranosides conjugated to carriers, and methods for making and use same. ed.
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JP5553168B2 |
Disclosed are an effective and highly safe agent or pharmaceutical preparation for ameliorating various disorders caused by an impaired brain function, and others. Specifically disclosed are: an agent for preventing or ameliorating an i...
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JP5539326B2 |
The invention relates to the use of certain derivatives of D-mannopyranoside for controlling angiogenesis. These compounds have a pro-angiogenic activity, and can particularly be used for preparing a pharmaceutical composition for treati...
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JP5538725B2 |
This invention relates to compositions and methods of preparing stable adjuvant diluent stock solutions and final adjuvant solutions comprising glycolipids, weak acids, alcohols, nonionic surfactants and buffers.
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JP2014513985A |
A method for generating human milk oligosaccharides (HMOs) or precursors thereof, compounds obtainable by the method, and uses and compositions involving such compounds. The method comprising the steps of a) providing at least one donor ...
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JP5515360B2 |
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JP5496181B2 |
A process for the extraction of sucralose from an aqueous solution containing at least sucralose, other chlorinated saccharides, sodium chloride and dimethylammonium chloride into an organic solvent for sucralose by contacting said organ...
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JP2014510098A |
A method for the synthesis of a fucooligosaccharide glycosides by reacting a fucosyl donor with H-A-R1 or a salt thereof, wherein A and R1 are as defined herein, under the catalysis of an enzyme capable of transferring fucose is provided...
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JP5431764B2 |
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JP5426099B2 |
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JP2014012684A |
To provide a method of rapidly and efficiently synthesizing positron emission tomography (PET) radiotracers including a radioisotope with a short half life used in the PET.One or more of the following steps are performed on a microfabric...
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JP2014001407A |
To use lipid conjugates consisting of phospholipids as a pharmaceutical.Phospholipid compounds (PL-Conjugates) of this invention have general formulae: [phosphatidyl ethanolamine-Y-]n-X, [phosphatidyl serine-Y-]n-X, [phosphatidyl choline...
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JP5356247B2 |
A composition comprising at least a compound (a) of general formula (I): and a fungicide compound (b) in a (a)/(b) weight ratio of from 1/1 to 1/1014. A method for preventively or curatively combating the pests and diseases of crops and ...
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JP5345928B2 |
A new class of paromomycin-derived aminoglycosides, which exhibit efficient stop-codon mutation suppression activity, low cytotoxicity and selectivity towards eukaryotic cells are provided. Also provided are processes of preparing these ...
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JP5341413B2 |
To provide a bacterium that belongs to the genus Klebsiella and has ability of producing L-tagatose from galactitol. The bacterium of the genus Klebsiella has ability of using 6-azide hexitol as a raw material in which the 6-position of ...
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JP5342163B2 |
To provide a method for introducing site-selectively different protective groups to various hydroxy groups of an alkyl β-D-(thio)glucopyranoside derivative. The method for producing a compound represented by general formula [7] (wherein...
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JP5327945B2 |
To provide a method for easily producing a glucoside from an unprotected sugar. The production method includes the use of a haloformamidinium derivative as a dehydrating condensation agent and a sugar having a free hemiacetal hydroxy gro...
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JP5318416B2 |
The invention relates to an improved process for the fluoridation of sugar derivatives in which a controlled amount of water is present in the solvent.
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JP2013189449A |
To provide polymers with specialized properties, making them particularly suitable for coatings on implanted medical devices, for forming films for use with medical devices, and other uses requiring the short- or defined-term presence of...
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JP5295124B2 |
The present application discloses a process for the synthesis of a sucrose-6-ester comprising: (a) forming a first reaction mixture comprising sucrose, a polar aprotic solvent, and an organotin-based acylation promoter; (b) removal of wa...
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JP5272395B2 |
There is disclosed a method for producing a 4-deoxy-4-fluoro-D-glucose derivative by reacting a D-galactose derivative with either sulfuryl fluoride (SO 2 F 2 ), trifluoromethanesulfonyl fluoride (CF 3 SO 2 F) or perfluorobutanesulfonyl ...
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JP5258582B2 |
An object of the present invention is to provide a novel trehalose compound that exhibits excellent immunostimulating activity and that can be supplied in a large quantity in an industrial scale, and a method for producing the trehalose ...
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JP5256509B2 |
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JP5232083B2 |
The properties of biologically active compounds, for example drugs and agrochemicals, which contain in their molecular structure one or more functional groups selected from alcohol, ether, phenyl, amino, amido, thiol, carboxylic acid and...
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JP2013523759A |
Hypersulfated disaccharides, preferably octasulfated sucrose, with utility in asthma or asthma related disorders are disclosed. The compounds may optionally be formulated with pharmaceutically acceptable excipients or delivery agents. Th...
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JP2013107885A |
To provide a method of conjugating peptides and proteins by means of glycosyltransferase.It is an object of the invention to provide means and methods which allow for a convenient synthesis or semisynthesis of therapeutic proteins, where...
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JP5197358B2 |
The present invention relates to a process for generating glucosamine from plants wherein fresh plant materials, or re-hydrated dried plant materials or plant extracts, are heated at a temperature comprised between 70 and 110° C. for mo...
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JP5196702B2 |
The present invention relates to novel extractive methods for purifying sucralose. The present invention also relates to compositions comprising the sucralose preparations made by the methods of the present invention.
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JP2013082728A |
To provide purine phosphoramidate compounds, potent inhibitors of the HCV virus; and to provide a method of preparing the same.This invention relates to: a compound I or salts thereof or a compound II or salts thereof; and a process for ...
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JP5188960B2 |
The present invention relates to a process for generating glucosamine from plants wherein fresh plant materials, or re-hydrated dried plant materials or plant extracts, are heated at a temperature comprised between 70 and 110° C. for mo...
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JP2013512938A |
The present invention relates to a zinc sucrose octasulfate of the general formula I, a process for preparing same and its use in the pharmaceutical and/or cosmetic field wherein: 0≰n≰4 n is an integer Y represents OH, Cl, Br, I, NO3...
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JP5174672B2 |
The invention provides a method of identifying biologically active compounds comprising: (a) designing a first library of compounds of formula (1) to scan molecular diversity wherein each compound of the library has at least two pharmaco...
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JP5155999B2 |
Certain novel substituted imidazole 4-carboxamides are ligands of the human cholecystokinin receptor and, in particular, are selective ligands of the human cholecystokinin-1 receptor (CCK-1R). They are therefore useful for the treatment,...
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JP2013032306A |
To provide a novel substrate which can identify the reaction specificity of CBH I and CBH II, and to provide a method for measuring the CBH I and CBH II activities using the same.The thioglycoside compound is represented by general formu...
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JP5139797B2 |
The invention relates to compounds which are polysulfated oligosaccharide derivatives having activity as inhibitors of heparan sulfate-binding proteins and inhibitors of the enzyme heparanase; methods for the preparation of the compounds...
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JP5134530B2 |
New salts or ion-pair complexes obtained by a reaction between boswellic acids or selectively enriched 3-O-acetyl-11-keto-beta-boswellic acid (AKBA) or 11-keto-beta-boswellic acid (KBA) compounds obtained through a new improved process, ...
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JP5132665B2 |
A process for separating, in the liquid phase, a reaction mixture which comprises a first chlorinated sucrose and at least one additional component selected from the group consisting of at least one other chlorinated sucrose different fr...
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JP2013014622A |
To provide pyridazinone derivatives useful as glucan synthase inhibitors.In its many embodiments, the present invention provides: substituted pyridazinone compounds as glucan synthase inhibitors; methods of preparing such compounds; phar...
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JP2012532195A |
The invention relates to a method of inhibiting inflammation with milk oligosaccharides or glycoconjugates containing the oligosaccharides.
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JP2012236851A |
To provide a process of making an α-anomer enriched 2-deoxy-2,2-difluoro-D-ribofunanosyl sulfonate, which is useful as an intermediate in the preparation of a β-nucleoside, such as an anti-tumor agent or gemcitabine.A β-2-deoxy-2,2-di...
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JP5091126B2 |
A process of preparing an alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofunanosyl sulfonate, which is useful as an intermediate in the preparation of a beta nucleoside, such as gemcitabine, an anti-tumor agent. A beta-2-deoxy-2,2-difl...
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JP2012530075A |
The invention relates to disubstituted-aminodifluorosulfinium salts represented by the formula (I). Processes for preparing same and methods of use as deoxofluorinating reagent is also provided.
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JP5072264B2 |
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