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JP2004210664A |
To provide an external preparation which has an improving effect on atopic dermatitis and has high safety.This external atopic dermatitis-improving preparation contains an acidic xylooligosaccharide having uronic acid residues in the mol...
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JP2004182618A |
To obtain a therapeutic agent for osteoporosis, which has excellent promotion effect of bone formation, is highly safe, has high stability and is applicable as a therapeutic agent for osteoporosis to the human body.The therapeutic agent ...
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JP2004138397A |
To provide a method for specifically transmitting physiologically active substances to a specific internal organ in a living body, for example the spleen or the thymus.A probe expressed by a following expression (I) is medicated to anima...
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JP2004512805A |
A process for producing nitrosonium ions is described, in which a nitroxyl compound such as TEMPO is oxidized using an oxidizing agent in the presence of a complex of a transition metal such as Mn, Fe, Cu, and a complexing agent such as ...
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JP2004511489A |
The invention relates to novel amidines and quanidines, the production and use thereof and the use thereof as trypsine-type serine protease competitive inhibitors, especially thrombine and compliment proteases CIs and C1r. The invention ...
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JP3512553B2 |
To obtain a constipation-suppressing agent suitable for preventing and improving of constipation, containing an oligogalacturonic acid and/or its salt. This arterial sclerosis-suppressing agent contains an oligogalacturonic acid of the f...
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JP3512552B2 |
To obtain an arterial sclerosis-suppressing agent having excellent activity and safety, containing an oligogalacturonic acid and/or its salt. This arterial sclerosis-suppressing agent contains an oligogalacturonic acid of the formula and...
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JP2004507587A |
The present invention provides a new class of compounds presenting a high compatibility with tissues and organic fluids. Such new compounds are polysaccharides, essentially formed of units of uronic acid and/or hexosamine, containing nit...
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JP3501415B2 |
PURPOSE: To obtain the subject stimulation agent containing N-acetylneuraminic acid and/or sialyllactose having strong growth stimulation activity against bifidus and lactobacillus as an active component and useful for an oral preparatio...
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JP3491033B2 |
To provide a method for producing useful N-glycolylneuraminic acid by using an unused resource, Cucumaria echinata as a raw material and a method for obtaining a high purity N-glycolylneuraminic acid in a high yield by treating the Cucum...
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JP3476455B2 |
Oligosaccharide compounds that are substrates and inhibitors of glycosyltransferase and glycosidase enzymes and compositions containing such compounds are disclosed. A method of glycosylation is also disclosed. An E. coli transformed wit...
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JP2003335762A |
To provide a new compound having high antibacterial activity on multidrug-resistant bacteria (e.g. MRSA, VRE, PRSP) as well as sensitive bacteria for which existing drugs are effective.The new compound is a biphenyl derivative of the gen...
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JP2003335683A |
To develop a technique capable of inexpensively obtaining a substance scarcely having fear of adverse effect, or the like, and having high safety and high hypertension-preventing effect in high yield, and to obtain the substance utilizab...
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JP2003300853A |
To obtain a composition of a skin care preparation rapidly raising skin bleaching effects in formation of pigmentation with sunburn or hormones, or the like, and formation of the pigmentation after inflammations (atopic dermatitis, burns...
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JP2003525859A |
Conjugates of a saccharide and an acetamidino- or guanidino-compound, of the formula:wherein A is CH3 or NH2; X is a linear or branched C1-C8 alkyl chain optionally containing hydroxy, amino and/or oxo groups; n is an integer from 1 to 6...
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JP2003523164A |
A process for purifying and concentrating a gluconic acid derivative, such as 2-keto-L-gulonic acid, comprising introducing a non-viable and/or acidified fermentation medium or an in-vitro reactor medium comprising at least the gluconic ...
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JP2003221339A |
To obtain an anti-inflammatory agent which has a high pharmacologi cal activity, is prepared by using a natural substance as a raw material, does not cause side effects, and is highly safe.This anti-inflammatory agent contains an acidic ...
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JP2003521513A |
The invention relates to the discovery that specific adamantyl or adamantyl group derivatives containing retinoid-related compounds induce apoptosis of cancer cells and therefore may be used for the treatment of cancer, including advance...
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JP2003176296A |
To provide a new monocyclic L-nucleoside compound which is supposed to be useful for treating various diseases including infections, parasite invasion, neoplasms and autoimmune diseases.This new L-nucleoside compound represented by the g...
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JP2003516939A |
In a new process for oxidizing a primary and/or secondary alcohol, an oxidizing agent is used in the presence of a di-tertiary-alkyl nitroxyl, in an aqueous reaction medium at a pH of below 7. The di-tertiary-alkyl nitroxyl is especially...
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JP2003514512A |
Chimeric carbohydrates produced by recombinant microorganism carrying exogenous glycosyl transferases act with or without exogenous enzymes required for synthesis or nucleotide synthesis precursors. These recombinant microorganism can be...
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JP2003511385A |
The current invention relates to the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including human) origin. In particular, this invention pr...
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JP2003506333A |
The present invention relates to a process for the purification of 2-keto-L-gulonic acid by continuous liquid chromatography using a weakly basic ion exchange resin.
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JP3374129B2 |
The invention relates to substituted benzo(b)thiepine-1,1-dioxide derivatives and to the acid addition salts thereof. The invention relates to compounds of formula (I), wherein R1, R2, R3, R4, R5 and Z have the cited descriptions, to the...
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JP2002542316A |
Crosslinked compounds of hyaluronic acid and the derivatives thereof, prepared by the technique of precipitation induced by supercritical antisolvent (SAS), can be used to advantage for the preparation of biomaterials for use in the fiel...
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JP2002541248A |
The invention relates to substituted 1,4-benzothiazepine-1,1-dioxide derivatives and their acid addition salts.1,4-Benzothiazepine-1,1-dioxide derivatives of formula 1,wherein R1, R2, R3, and Z have the meanings indicated in the specific...
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JP2002335988A |
To provide a method for the efficient synthesis of an oligosaccharide by the combination of a cyclic synthesis of a sugar nucleotide accompanying the regeneration of nucleoside 5'-triphosphate(NTP) from inexpensive nucleoside 5'-monophos...
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JP3345020B2 |
A synthetic polysaccharide including an antithrombin III binding domain consisting of a concatenation of five monosaccharides supporting a total of two carboxylic acid functions and at least four sulpho groups, said domain being directly...
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JP2002537374A |
A process for producing nitrosonium ions is described, in which a nitroxyl compound such as TEMPO is oxidized using an oxidizing agent in the presence of a complex of a transition metal such as Mn, Fe, Cu, and a complexing agent such as ...
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JP2002533477A |
A system and method for providing improved de novo structure-based drug design that includes a method for more accurately predicting binding free energy. The system and method use a coarse-graing model with corresponding knowledge-based ...
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JP2002533400A |
Methods for preventing or treating a viral infection in a subject are described that include administering N-glycolylneuraminic acid or a derivative thereof to the subject.
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JP2002532719A |
The present invention provides a method for immobilising a polysaccharide (PS) to a solid surface, said polysaccharide having a keto-carboxy group (-C(=O)-COOH) or a ketal or hemiketal group corresponding thereto, e.g. derived from KDO (...
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JP2002530288A |
The present invention discloses chemiluminescent 1,2-dioxetane substrates capable of reacting with a neuraminidase to release optically detectable energy. These 1,2-dioxetanes have the general formula:wherein Z isand the variables are se...
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JP2002525375A |
The invention is directed to a method for synthesizing C-glycosides of ulosonic acids, as well as intermediates thereof and C-glycosides prepared by this method.
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JP2002218992A |
To provide a method for the preparation of a saccharide composition.The method is a reiterative method comprising the following three steps. (i) A step of bringing an acceptor moiety composed of proteins, glycoproteins, lipids, glycolipi...
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JP2002153294A |
To provide a method for easily producing a glucuronic acid compound and/or D-glucuronolactone on an industrial scale at low cost in high yield, and to provide a method for producing a composition comprising the glucuronic acid compound a...
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JP3286340B2 |
PURPOSE: To provide a new sialic acid derivative useful as a neuropathy therapeutic agent, cancer cell metastasis-inhibiting agent, antiinflammatory agent, demyelinating disease-therapeutic agent, etc., chemically and enzymatically stabl...
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JP2002514652A |
Disclosed are novel 1-galactose derivatives having a carbon- or nitrogen-containing aglycon linkage. The disclosed compounds inhibit binding of toxins, such as heat-labile enterotoxin or cholera toxin, to their receptors either in vitro ...
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JP2002515064A |
Novel piperidine compounds are provided, and those compounds are useful in the treatment and/or prevention of diabetes, and especially non- insulin dependent diabetes (NIDDM or type 2 diabetes) including overnight or meal treatment and t...
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JP2002513809A |
Primary alcohols, especially in carbohydrates, can be selectively oxidized to aldehydes and carboxylic acids in a low-halogen process by using a peracid in the presence of a catalytic amount of a di-tertiary-alkyl nitroxyl (TEMPO) and a ...
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JP2002068970A |
To obtain a new sugar derivative which is not metabolized with Sreptcoccus mutans as bacterium causing dental caries to prevent the dental caries, and thereby substantially does not cause acidification due to the production of lactic aci...
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JP2002503212A |
Novel monocyclic L-Nucleoside compounds have the general formula Embodiments of these compounds are contemplated to be useful in treating a wide variety of diseases including infections, infestations, neoplasms, and autoimmune diseases. ...
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JP2002502393A |
(57) [Summary] A scaffold-designed sugar compound and sugar compound library incorporating a carboxylic acid moiety, a free or protected hydroxyl group, and an amino group or a protected amino group is disclosed.
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JP2002501546A |
C-nucleosides are synthesized by a method in which a sugar is derivatized in a single step to provide a heterocycle at the C1 position, and then the heterocycle is aromatized in another single step. In one class of preferred embodiments ...
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JP2002500167A |
The present invention discloses a method for the synthesis of derivatives of aloesin, alkylated at the C-7 hydroxyl group. The present invention includes the modified aloesins produced by the method of this invention and the use of these...
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JP3242472B2 |
PURPOSE: To obtain a new low toxic compound, having water-solubility and useful as a cancerous cell metastatic suppressor. CONSTITUTION: (3S,4S,5R,6R)-6-(Trifluoroacetamino)-4,5-dihydroxypiperdine-
3- carboxylic acid of formula I and its...
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JP2001515912A |
The present invention is directed to novel compositions and their use in the treatment of inflammatory responses. Specifically, the invention is directed to novel synthetic oligosaccharide constructs and their use to block lymphocyte bin...
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JP2001514865A |
The present invention provides methods for producing sialyloligosaccharides in situ in dairy sources and cheese processing waste streams, prior to, during, or after processing of the dairy source during the cheese manufacturing process. ...
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JP2001240599A |
To obtain a lactic oligosaccharide fraction having a high sialic acid content.The lactic oligosaccharide fraction, is obtained by adding ethanol into a lactic oligosaccharide fraction with weight ratio of sialic acid to hexose is ≥1.0 ...
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JP3202365B2 |
PURPOSE: To efficiently separate oligomannuronic acids according to polymerization degree by treating a mixture of the oligomannuronic acids different in polymerization degree by the anion-exchange chromatography using a bicarbonate comp...
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