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WO/2004/072094A2 |
An HMGB 1 modulator binding domain having the structure substantially as presented by the space filling balls in Figure 4 or Figure 11.
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WO/2004/072092A1 |
The invention relates to novel derivatives of betulinic acid with increased activity for the treatment of carcinomas and HIV diseases, to a method for producing novel betulinic acid derivatives of this type and to their use as medicaments.
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WO/2004/052383A1 |
The present invention relates to an composition containing triterpenoid saponins extracted from Bamboo, and the preparation method and use thereof. The triterpenoid saponins are extracted from various parts of bamboo belonging to Gramine...
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WO/2004/035601A1 |
The present invention includes the use of pelorol, related compounds and pharmaceutical compositions thereof as modulators of SHIP 1 activity. This invention also provides novel terpene compounds capable of modulating SHIP I activity and...
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WO/2004/028455A2 |
Betulin and dihydrobetulin acyl derivatives according to the present invention have been found to have potent anti-HIV activity. The compounds of the present invention have Formula I as described herein, or pharmaceutically acceptable sa...
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WO/2004/009521A1 |
A remedy or a preventive for diseases with a need for the enhanced production of nerve growth factor (NGF) for the treatment or prevention thereof, an NGF production enhancer and a food, a drink or a feed for enhancing NGF production eac...
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WO/2003/104253A2 |
The invention relates to novel 9$g(a)-substituted estratrienes of general formula (I) - wherein R3, R7, R7', R13, R16, R17 and R17' have the designations cited in the description, and R9 represents a linear-chain or branched-chain, optio...
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WO/2003/099218A2 |
Composition for halting the metastasis of cancer cells comprising rubidum ursolate. The rubidium ursolate is formed from a mixture of rubidium and ursolic acid obtained from the bark of the Virburnum plant.
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WO/2003/095979A1 |
Methods for the pressurized hot water extraction (PHWE) of compounds from a sample of interest are disclosed. Applications of the method to the extraction of bioactive compounds from botanical samples are disclosed. The disclosed methods...
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WO/2003/089593A2 |
An improved method is provided for treating disease states characterized by the existence of pathogenic cell populations. In accordance with the improved method, cell-targeted ligand-immunogen or ligand-hapten complexes are administered ...
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WO/2003/080643A1 |
A process for producing the compound (V) or a salt thereof, the process being shown by the following reaction scheme. (II) (I) → (III) → (IV) → (V) (In the scheme, R1 and R2 each independently represents C1-8 alkyl.)
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WO/2003/070263A1 |
It is intended to provide a process for obtaining a hydrophobic glycyrrhiza extract which is useful in foods, food additives, foods with nutrient function claims, foods for specified health uses, foods with health claims, drinks, feeds, ...
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WO/2003/066658A2 |
The invention relates to an improved method for preparing pure, crystalline betulin from a birch bark extract, said betulin being essentially free of betulinic acid.
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WO/2003/066659A2 |
The invention relates to an improved method for obtaining highly pure, crystalline betulinic acid from a methanolic extract of ground plane bark and/or plane rind. The invention also relates to a highly pure, crystalline betulinic acid, ...
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WO/2003/062260A1 |
The invention provides novel compounds that are quaternary amine derivatives of betulin and other triterpenes. The compounds have antibacterial, antifungal, and surfactant properties.
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WO/2003/057224A1 |
An apoptosis inductor containing as an active ingredient a compound having the effect of inducing apoptosis which is selected from the group consisting of maslinic acid, erythrodiol, uvaol, betulin, physiologically acceptable salts of th...
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WO/2003/045971A2 |
The present invention relates to 3β,28-diacetoxy-18-oxo-19,20,21,29,30-pentanorlupan-22-oic acid methanol solvate, its use in medicine and processes for its preparation.
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WO/2003/033517A1 |
The present invention includes the use of pelorol and related sesquiterpene compounds as modulators of SHIP 1 activity. This invention also provides novel sesquiterpene compounds capable of modulating SHIP 1 activity and methods of synth...
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WO/2003/033518A1 |
There is provided a compound having Formula (I) wherein G is H or a substituent, and wherein R?1¿ is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group, capable of inh...
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WO/2003/028475A1 |
Feeds, fertilizers, melanin−formation inhibitors for animals and plants and blackening&sol browning inhibitors for animals and plants which contain as the active ingredient(s) one or more members selected from among pentacyclic triterp...
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WO/2003/029391A1 |
A process for industrially and efficiently producing fat compositions containing oleanolic acid, maslinic acid, physiologically acceptable salts thereof and derivatives of the same. This process involves the step of extracting olive plan...
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WO2002068548A9 |
The present invention discloses the use of ERSS-selective ligands for production of medicaments for regulating fertility without additional use of a progestin. ERSS-agonists are used for treatment of infertility and ERSS-antagonists for ...
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WO/2003/011891A1 |
The present invention provides a process for the isolation of betulinic acid by extracting rhizomes of Nelumbo nucifera Gaertn (Family - Nymphaeaceae) with a polar solvent by conventional soxhlet extraction methods, concentrating the ext...
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WO/2002/094301A1 |
The present invention relates to a herbal drug composition for cartilage protection comprising plant extracts of Clematis Radix, Trichosanthis Radix, and Prunellae Spica and an optimal content of rosmarinic acid to: (i) alleviate pains; ...
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WO/2002/089791A2 |
The invention relates to the use of lipooxigenase inhibitors for treating acne, particularly inflammatory acne. The inventive lipooxigenase inhibitor can be used alone or in combination with other lipooxigenase inhibitors or anti-acne ac...
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WO/2002/086142A1 |
It is intended to provide a novel process for producing soyasapogenol B which is useful as a drug or a material for producing drugs. Sophoradiol employed as a starting material is treated with a hydroxylase originating in a plant to ther...
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WO/2002/085827A1 |
The invention relates to an extract from the pods of lupin seeds containing lupeol, more particularly an extract wherein the content thereof by weight is greater than 30 %, preferably greater than 50 %, even more advantageously 70 - 100 ...
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WO/2002/085921A2 |
The invention relates to a method for producing a pure boswellic acid from a boswellic acid mixture, comprising the following steps; (a) acetylation by a suitable acetylation reagent or deacetylation by a suitable deacetylation reagent, ...
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WO2001072315A9 |
The invention relates to a method for obtaining triterpenes from plants and/or the constituents thereof, in addition to an emulsion whose aqueous and fatty phase is emulsified by the plant extract. The plant extract contains at least one...
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WO/2002/076435A2 |
The invention provides use of an agent which lowers levels of 11$g(b)-HSD1 in the manufacture of a composition for the promotion of an atheroprotective lipid profile, for reducing cardiovascular disease risk, for increasing insulin sensi...
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WO/2002/072536A1 |
The invention relates to novel compounds having Vanilloid Receptor (VR1) antagonist activity, processes for their preparation, to compositions containing them and to their use in the treatment of various disorders.
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WO/2002/067962A1 |
The invention discloses a method for preparating an anemone raddeana extract and a pharmaceutical composition containing the same as well as use thereof, the method comprises the following steps: a) the rhizome, stem, leaf, flower and fr...
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WO/2002/066491A1 |
A new composition which can be formed through a method comprising: (a) dissolving mixtures of boswellic acids in a water and alcohol solution to form a mixture; (b) adding one or more alkali salts to the mixture to form a salt solution; ...
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WO/2002/055529A2 |
A method for recovering soy saponis which comprises extracting a soy isoflavone concentrate derived from soy molasses with a mixture of acetone and water, removing undissolved solids from the extract, cooling the extract such that soy sa...
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WO/2002/043736A1 |
Foods and drinks, each containing one or more members selected from among pentacyclic triterpenes, physiologically acceptable salts thereof, and derivatives of both; and peroral beautifying preparations each containing as the active ingr...
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WO/2002/026761A1 |
Methods of treating a fungal or yeast infection and of killing or inhibiting fungi or yeast are disclosed. The methods use derivatives of triterpenes that are abundant in birch bark and other plants. The triterpenes include betulin, allo...
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WO/2002/026762A1 |
Methods of treating a bacterial infection and of killing or inhibiting bacteria are disclosed. The methods use derivatives of triterpenes that are abundant in birch bark and other plants. The triterpenes include betulin, allobetulin, and...
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WO/2002/016395A1 |
A composition and method of preventing or inhibiting tumor growth and, more particularly, of treating a malignant tumor, using prodrugs of plant-derived compounds and derivatives is disclosed. In the method, a composition containing betu...
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WO/2002/012159A1 |
A process for producing oleanolic acid and/or maslinic acid and physiologically acceptable salts thereof characterized by comprising extracting with water and/or an organic solvent olive plant and/or products formed in the course of the ...
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WO/2002/004410A1 |
A process for producing a sulfamate compound which comprises reacting a hydroxylated compound with sulfamoyl chloride, characterized in that the reaction is conducted in the presence of a compound such as N,N-dimethylacetamide or 1-methy...
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WO/2001/090046A1 |
The present invention relates to the use of a compound of formula (I), or a pharmaceutically acceptable salt, crystal form, complex, hydrate, or hydrolysable ester thereof, in the preparation of a medicament for treating a patient suffer...
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WO/2001/090136A2 |
The present invention relates to the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in therapy. Preferably, the compound may be used for treating a patient suffering from leukaemia, cancer or other proli...
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WO/2001/064709A1 |
A novel, simple and ecofriendly method for manufacturing betulinic acid from the plant extract of Ziziphus jujuba (Rhamnaceae) by solvent crystallisation without employing chromatographic separation.
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WO/2001/049293A1 |
The present invention relates to a pharmaceutical composition that is lower toxicity and antiphlogistic as well as anti-exudation. The composition contains escin of general formula (I) and escin of general formula (II) as active componen...
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WO/2001/030803A1 |
The invention provides B-ring expanded estra-1,3,5(10)-triene compounds of general formula (1) which modulate the polymerization of tubulin and/or the depolymerization of microtubules. The compounds have anti-angiogenic and anti-tumor ac...
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WO/2001/018029A1 |
The invention relates to novel betulinic acid derivatives having antiangiogenic activity, processes for producing such derivatives and their use for treating tumor associated angiogenesis.
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WO/2001/015717A1 |
Medicinal compositions and preparations for administration comprising ginseng, which is useful as a cell protecting agent and a remedy for nerve trauma, its extract, ginseng components, metabolites thereof or salts thereof (for example, ...
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WO/2001/010885A2 |
The invention provides methods for separating outer birch bark from inner birch bark. The invention also provides methods for isolating betulin; lupeol; betulinic acid; 9,10-epoxy-18-hydroxyoctadecanoic acid; 9,10,18-trihydroxyoctadecano...
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WO2000046235B1 |
The invention relates to novel betulinic acid derivatives of structural formula having modifications at C2, C3, C17, C20 and/or C29 positions, said derivatives being useful as inhibitors of tumor/cancer cells; process for preparation of ...
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WO/2000/047594A1 |
This invention relates to novel gymnemic acid derivatives represented by formula (I) and (II), pharmaceutical compositions containing them and their use as medicine.
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