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Patent Searching and Data


Matches 701 - 750 out of 1,207

Document Document Title
JP2008120839A
To provide a compound useful for treating mammalian diseases characterized by undesired cell mitosis.A new estradiol derivative binds to tubulin, inhibits microtubule formation or exhibits anti-mitotic properties.  
JP2008120840A
To provide a compound useful for treating mammalian diseases characterized by undesired cell mitosis.A new estradiol derivative binds to tubulin, inhibits microtubule formation or exhibits anti-mitotic properties.  
JP2008105964A
To provide a simple and low-cost manufacturing method for extracting, from a plant, saponin having industrially high versatility as a raw material from which components other than saponin are moderately removed.The manufacturing method o...  
JP2008513360A
Novel compounds such as compounds designated herein as Xanifolia-Y or -Y3, -Y1, -Y2, -Y8, -Y9 and -Y10 are disclosed. These compounds have anticancer activity. The compounds of the present invention are obtainable from plants in the sapi...  
JPWO2005110958A1
過酸化水素およびタングステン触媒を含有す る混合試薬を用い、アミド系溶媒中でアルコ ールを酸化する方法。  
JP4057765B2  
JP2008505886A
This invention relates to novel corosolic acid analogs of the formula I, wherein R1, R2, R3, R4 and R5 are described herein. These compounds exhibit good hypoglycemic and 5-lipoxygenase inhibitory activities. They also inhibit tumour gro...  
JP4052485B2
A composition and method of inhibiting tumor growth and treating malignant melanoma without toxic side effects are disclosed. Betulinic acid or a betulinic acid derivative is the active compound of the composition, which is topically app...  
JP2008504337A
The invention relates to novel 2-substituted D-homo-estra-1,3,5(10)-trienes of general formula (I) wherein R2 represents a C1-C8 alkyl, a C1-C8 alkyloxy group or a halogen atom, R13 represents a hydrogen atom or a methyl group, and R17 r...  
JP2004529961A5  
JPWO2005090285A1
The medicine tablet obtained using the new crystal, its manufacturing method, and the crystal concerned of a new Triterpen derivative is provided. [Formula 1] The crystal of compound (I) come out of and shown.  
JPWO2005027892A1
The present invention is an initial secretion catalyst of an insulin which consists of corosolic acid etc. According to the initial secretion catalyst of an insulin of the present invention, an insulin is made to secrete quickly immediat...  
JP2007529544A
Salts of 3-O-(3',3'-dimethylsuccinyl)Betulinic acid (DSB) are disclosed. Particularly, the preparation, pharmaceutical evaluation, and in vivo bioavailability evaluation of N-methyl-D-glucamine and alkali metal salt forms of DSB are disc...  
JP3984310B2  
JP2007238468A
To find a new pharmacological action of saponins derived from seeds of Aesculus turbinata and provide a use of the saponin. Unknown lipase inhibition activity has been found in saponins such as escin existing in seeds of Aesculus turbina...  
JP3968114B2
To provide a new steroid compound useful as an anti-estrogenic agent. The compound has a structure of formula (III). The invention further relates to a pharmaceutical composition containing the compound or its pharmaceutically permissibl...  
JP2007523058A
This invention provides methods and process of identification and producing pure, biologically active compound(s) from Xanthoceras sorbifolia. This invention also provides the composition of the pure compound(s) of interest from Xanthoce...  
JP3958101B2
To improve Corey-Kim oxidation of an alcohol. The reagent for oxidation reaction of an alcohol comprises a compound represented by the formula: P-X1-SR (I) (wherein P is a polymer residue; X1 is a spacer; R is H or CH3). The reagent redu...  
JP2007186442A
To provide a new skin care preparation, excellent in safety and suitable for inhibiting the melanin production.This skin care preparation suitable for inhibiting the melanin production is provided by containing amorisin expressed by the ...  
JPWO2007072845A
Formula (I) :(Inside of a formula, R)1は水素 or a metabolic ester 残 machine is expressed, and it is R.2は水素 or *R3*R4(Being here. R)3は, *SO3* *CH2COO*, *COCOO*, or *COR5COO* (being here R)5は, low-grade Al Killen, or low-gra...  
JP2007161684A
To provide a triterpene compound having an excellent melamine production-inhibiting effect, and to provide an external preparation used for the skins and containing the compound as an active ingredient.This triterpene compound is represe...  
JP2007143413A
To provide a method for eliminating unfavorable smell-causing components and bitter taste components which a quillai extract contains, and a method for producing quillai extract from which the unfavorable smell-causing components and the...  
JP2007515455A
The invention provides 19-nor-D-homosteroids, having a mixed androgenic/progestagenic profile, which are orally active, prevent trabecular bone mineral density (BMD) loss, and which lack liver toxicity, having a structure according to th...  
JP2007512258A
Various compounds obtained from plants of the Barringtonia species which are derived from Barringtoside A and Barringtoside C as precursor compounds which especially have an arabinopyranosyl substituent at the 21 position which may optio...  
JP2005325076A5  
JP2007508294A
The present invention relates to the triterpene compounds improving in brain functions. In particular, the present invention relates to a novel use of the triterpene compounds represented by the Formula 1 for improving decreased memory a...  
JP2007506761A
The present invention relates to novel synthetic derivatives of triterpenes and the use of such derivatives as pharmaceuticals. The present invention is directed to novel compounds of Formula I: or pharmaceutically acceptable salt or est...  
JP2007051101A
To elucidate a compound originated from Hippophate rhamnoides L, and having an anti-inflammatory effect, and also develop a new use of the compound.This nitrogen monoxide production inhibitor and radical-eliminating agent contains a trit...  
JP2007502801A
The invention relates to Delta15-D-homosteroids of general formula (I) process for their production and pharmaceutical compositions that contain these compounds. The compounds of general formula I according to the invention have androgen...  
JP2007022923A
To provide a hair follicle apoptosis inhibitor having prevention of fallen hair caused by hair follicle apoptosis and growth promotion effect of healthy hair thereby, and a hair cosmetic composition in which the hair follicle apoptosis i...  
JPWO2006132033A
By phosphorylating at least one of the hydroxyl groups of Tori terpene acid which has a hydroxyl group, and guiding to phosphorylation Tori terpene acid and/or its salt, the solubility in the inside of a skin medicine for external applic...  
JP2006327965A
To provide a skin care preparation capable of being suitably applied to inflammation such as allergic inflammation and atopic dermatitis, of which the control is difficult for an ordinary anti-inflammatory, such as indomethacin or predni...  
JP2003508543A5  
JP2006265232A
To obtain a skin cosmetic formulated with a substance having an elastase inhibitory action, an inhibitory action on matrix metalloprotease-1, a promotion action on epidermal keratinocyte proliferation or a promotion action on fibroblast ...  
JP3828953B2
To obtain an inhibitor of a lipase, having high safety and high inhibiting activities against the lipase and capable of preventing a food from deteriorating by blending at least one of a compound of triterpenes and its derivative, etc., ...  
JP2006522051A
A process for producing an extract of ivy leaves using an extracting agent, with the extract comprising alpha-hederin. In this process, a quantity of dried ivy leaves is first of all comminuted, then fermented by adding water and subsequ...  
JP2006520756A
Inhibition of HIV-1 replication by disrupting the processing of the viral Gag capsid (CA) protein (p24) from the CA-spacer peptide 1 (SP1) protein precursor (p25) is disclosed. Amino acid sequences containing a mutation in the Gag p25 pr...  
JP3820349B2
A sulphamate compound suitable for use as an inhibitor of oestrone sulphatese (E.C.3.1.6.2) is described. The compound is a polycyclic compound comprising at least two ring components, wherein the polycyclic compound comprises at least o...  
JP3810827B2
PURPOSE: To easily obtain at low cost in an industrially advantageous way a tea leaf saponin useful for the food area, medicines, quasi-drugs etc., by subjecting the hot water extraction residues of tea leaves to extraction with a hydrou...  
JP2006517946A
This invention relates to 2-substituted D-homo-estra-1,3,5(10)-trien-3-yl sulfamates of general formula I (I), in which R3 means a C1-C5-alkyl or C1-C5-alkyloxy group as well as their use for the production of a pharmaceutical agent for ...  
JPWO2006077801A
How to manufacture the compound shown by formula (II) by making the compound shown by formula (I) react using hydrogen peroxide and a molybdenum catalyst.(Inside of a formula, R)1And R1'It is low-grade アルキル which may achieve は...  
JP3802034B2
To obtain a cosmetic composition highly stimulating collagen synthesis. Betulic acid is used in production of therapeutic agents for wrinkles of the skin, slackening of the skin, phlegmon and actinic diseases. The betulic acid is used in...  
JP2006517208A
The present invention relates to novel betulinic acid derivatives with increased activity for the treatment of carcinomas and HIV diseases, a method for preparing such novel betulinic acid derivatives as well as their use as pharmaceutic...  
JP2006516962A
Production of an extract (A) of Centella asiatica, containing a mixture of madecassoside (I) and terminoloside (II), involves: (a) extracting above-ground plant parts with alcoholic solvent; (b) passing the extract through anionic resin;...  
JP2006169236A
To provide a new diabetes-therapeutic agent having both properties of a biguanide-based medicine and a nateglinide-based medicine and reduced in adverse effects less than those of the medicines.The new diabetes-therapeutic agent is a gly...  
JP2006151902A
To provide a metastasis-controlling substance excellent in controlling metastasis of tumor cells such as malignant melanoma, neuroblastoma, glioblastoma and astrocytoma, and a composition containing the same.A triterpene derivative for c...  
JP2006515859A
New triterpenoid derivatives with various substituents at the C-17 position of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO) were synthesized. Among them, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile (CNDDO), 1-(2-cyano-3...  
JP2005532296A5  
JP3783200B2
To obtain a composition having a vascularizing action. This vascularizing agent is characterized by formulating friedelin and/or an extract obtained from one or more plants selected from plants containing the friedelin.  
JP2006124324A
To provide a method for producing soybean saponin, capable of easily purifying and obtaining the high-purity saponin, especially a soybean saponin B group having high biological activity.This method for producing the high-purity soybean ...  

Matches 701 - 750 out of 1,207