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WO/2009/067032A1 |
The invention relates to the lovastatin esterase enzyme immobilized on a solid support insoluble in water, the enzyme being covalently bound to a solid support activated with an at least difunctional coupling reagent, the immobilized lov...
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WO/2009/063312A2 |
Plant metabolism and alkaloid levels can be regulated by transcription factors that regulate the nicotinic alkaloid biosynthetic pathway.
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WO/2009/056539A1 |
The present invention relates to the biotechnological production of the HMG-CoA reductase inhibitor simvastatin by us ing a microorganism capable of producing monacolin J, a transesterase and the addition of 2,2-dimethylbutyric acid or a...
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WO/2009/054138A1 |
Disclosed is a novel process for producing a compound represented by the general formula (1) by using a microorganism, wherein the compound is useful as a plant growth stimulant. Specifically disclosed is a process for producing a succin...
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WO/2009/045383A1 |
Methods and materials for the production of the high intensity sweetener, monatin, in stereoisomerically-pure or stereoisomerically-enriched form are disclosed. For example, methods using stereoisoselective hydrolysis and separation of a...
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WO/2009/046153A1 |
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzy...
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WO/2009/040828A1 |
The present invention relates to a process for purification of mycophenolic acid comprising steps of: (a) extracting mycophenolic acid solution in a first water immiscible solvent with a first aqueous base to selectively remove polar imp...
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WO/2009/035407A1 |
The present invention relates to novel processes for the preparation of intermediate compounds which can be used to prepare therapeutic agents. The present invention also relates to novel intermediate compounds which can be used to prepa...
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WO/2009/032264A1 |
Processes of preparing an ezetimibe intermediate by microbial reduction and further converting the intermediate to ezetimibe are provided. Also provided is an ezetimibe intermediate with high diastereomeric excess.
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WO/2009/031195A1 |
[MEANS FOR SOLVING PROBLEMS] A composition effective in inhibiting the growth of human cancer cells, characterized by containing as an essential ingredient a flavonone compound monomer represented by the formula (1). [Chemical formula 1]...
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WO/2009/030098A1 |
A cellulosimicrobium cellulans and its hydrolase, which effectively transforms taxane xylosides into paclitaxel or its analogs. A method of high effectively preparing paclitaxel and its analogs by biotransformation reactions using the hy...
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WO/2009/028338A1 |
It is intended to provide a means of achieving the economical and convenient production of 3-indole-pyruvic acid. By using a polynucleotide that has a definite base sequence encoding a protein having an oxidase activity, a transformant i...
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WO/2009/029554A2 |
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzy...
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WO/2009/025439A1 |
The present invention relates to a fermentation and purification method of tricyclo compounds, especially FK506 and/or FK520, in detail, relates to a purification method by adding a hydrophobic adsorbent resin as their carrier in a cultu...
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WO/2009/021875A1 |
The present invention provides the genes encoding the biosynthetic pathway enzymes and the biosynthetic pathway enzymes for producing in a host micro-organism the compound etnangien. The invention provides the coding sequences and the re...
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WO/2009/023174A2 |
A method of converting hydroxymethylfurfural and is derivative species into hydroxymethylfurfural oxidation products is disclosed. The method includes contacting the hydroxymethylfurfural species in a mixture with an enzyme that oxidizes...
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WO/2009/019900A1 |
It is intended to provide an industrial purification method for PDC obtained by fermentative production. A purification method for 2-pyrone-4,6-dicarboxylic acid, characterized by allowing a monovalent to tetravalent cationic salt to exi...
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WO/2009/019561A2 |
The present invention is directed to a 2-deoxyribose-5-phosphate aldolase (DERA) chemoenzymatic process for making chiral compounds.
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WO/2009/015478A1 |
The invention provides a bacterial isolate defined by accession number 180507-1 filed with the International Depository Authority of Canada. The bacteria are capable of degrading trichothecene mycotoxins. Also provided are compositions c...
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WO/2009/009906A1 |
A method for producing one or more than one isoflavonoid compound in a plant is described. The method comprises providing a production plant comprising one or more than one nucleotide sequence encoding isoflavone glycosyltransferase oper...
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WO/2009/008503A1 |
Disclosed is a process for producing theaflavin selectively, in large quantity, in high yield, simply, and at low cost. Specifically disclosed is a process for producing theaflavin, which is characterized by mixing a processed plant extr...
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WO/2009/008834A1 |
Two novel microorganisms, Acinetobacter baumanni ATCC PTA-8303 and Cryptoeoecus albiduz ATCC PTA 8302 having epoxide hydrolase activity are described. The epoxide hydrolases from these microorganisms can be used to selectively hydrolyze ...
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WO/2009/007759A1 |
The invention relates to a process for the preparation of enantiomers of cyclic cis γ-amino acids and their derivatives of formula (I) wherein R1 is hydrogen atom or selected from the group consisting of alkyl, alkenyl, alkynyl, cycloal...
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WO/2009/009117A2 |
Compounds and processes for preparing intermediates in the synthesis of levetiracetam and precursors of levetiracetam and related compounds are provided. Also provided are processes for the preparation of levetiracetam or a pharmaceutica...
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WO/2008/151526A1 |
A method of inducing taxane production by utilizing Taxus sp. cells, wherein Taxus sp. cells are cultured in the media, the inoculation amouts of the cells are 50-200g/L wet weight, at the cell index growth early phase, an inducing agent...
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WO/2008/151636A1 |
The present invention relates to novel tools for improving MPA production. In particular, the present invention relates tofungal enzymes that are specific for MPA synthesis.
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WO/2008/153094A1 |
Disclosed is a method for producing an alkaloid (e.g., reticulin), which comprises the step of causing a monoamine oxidase, a norcoclaurine 6-O-methyltransferase, a coclaurine N-methyltransferase and a 3'-hydroxy-N-methylcoclaurine 4'-O-...
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WO/2008/144792A1 |
The invention relates to a method for producing ascorbic acid, according to which in a first step a carbon source is converted by fermentation into 2,5-diketo-D-gluconic acid, which is then enzymatically reacted with 2,5-diketo-D-gluconi...
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WO/2008/142433A1 |
A process for producing a composition comprising at least 3% by weight of total tocopherols and tocotrienols comprises: providing a product obtained from palm oil comprising tocopherols and tocotrienols, together with free fatty acids an...
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WO/2008/144073A1 |
The present invention provides a process for the preparation of a 4H- pyrrido[l,2-a]- pyrimidin-4-one derivative, wherein the 4H-pyrrido[l,2-a]- pyrimidin- 4-one derivative is Paliperidone or 3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hydrox...
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WO/2008/142155A2 |
The present invention concerns a method for preparing C-6 phosphorylated D- aldohexoses and C-6 phosphorylated D-aldohexose derivatives, new C-6 phosphorylated D-aldohexoses derivatives and uses thereof. The method comprises incubating p...
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WO/2008/143150A1 |
It is intended to produce 3-carboxy-cis,cis-muconic acid via fermentation from terephthalic acid on an industrial scale. A gene-disrupted strain of protocatechuic acid 4,5-ring cleaving enzyme in which, on chromosomal DNA in a microbial ...
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WO/2008/138243A1 |
Provided is a preparation method of icaritin, comprising treating the icariin with β-glucosidase in ethanol-water solution, then obtaining the icaritin by centrifugation and recrystallization. Also provided is a preparation method of ic...
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WO/2008/139844A1 |
It is intended to provide a microorganism having an excellent ability to specifically oxidize a hydroxymethyl group of glucose and a method for producing glucuronic acid and/or glucuronolactone by direct oxidation of glucose using this m...
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WO/2008/136753A1 |
Method to produce eritadenine by liquid phase fermentation of Lentinus edodes without formation of the fruit body wherein the Lentinus edodes is exposed to shear during its cultivation.
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WO/2008/132531A1 |
The present invention provides a fermentative production of clavulanic acid using agro-industrial residues and solid-state fermentation technique. The process involves cultivating the selected strain of Streptomyces clavuligerus MTCC 114...
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WO/2008/127663A1 |
The present invention relates to methods for reducing impurities of mycophenolic acid during fermentation by controlling the level of carbon source during fermentation of mycophenolic acid and for the isolation and use as a standard mark...
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WO/2008/122511A2 |
The present invention relates to biocatalytic asymmetric reduction for the preparation of 2-amino- [5-( l-hydroxy-2-hydroxy or halogen-ethyl) ] -pyrazine derivatives of the formula (formula I) wherein R is lower alkylcarbonyl or an amino...
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WO2008001306B1 |
The present invention relates to an isolated microorganism of the strain type SPRT (=DSM 44925T = NRRL B-24448T). The microorganism preferably includes genetic material of GenBank accession number DQ141528 (16S-rDNA-sequence). The invent...
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WO/2008/114954A1 |
The present invention relates to uses of Macrolactin A produced by Bacillus polyfermenticus KJS-2 (KCCM 10769P), which is a new bacillus strain, as an antibiotic. Macrolactin A of the present invention, which is produced by Bacillus poly...
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WO/2008/102253A2 |
Provided are methods for the biosynthesis of tetrodotoxin (TTX) comprising the steps of: obtaining a culture from a seed culture or storage possessing one or more of Vibrio species, inoculating the culture and a growth tissue extract fro...
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WO/2008/096021A2 |
Process for continuous production of lovastatine. The present invention consists of the production of lovastatine, from cultures of Aspergillus terreus in the form of pellets, by means of a continuous fermentation process in a bubble col...
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WO/2008/096586A1 |
Disclosed is a novel methylated catechin having higher antiallergic activity than conventionally known methylated catechins such as epigallocatechin-3-O-(3-O-methyl) gallate and epigallocatechin-3-O-(4-O-methyl) gallate. Specifically dis...
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WO/2008/098199A2 |
Polynucleotides encoding the polypeptides involved in biosynthesis of FK 228 and those involved in synthesis of a novel FK228 analog, thailandepsin are disclosed herein. Also provided are methods of making FK228, thailandepsin and analog...
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WO/2008/092950A1 |
The present invention relates to the improved production of pravastatin by fermentation using unpurified or partially purified raw materials or precursors.
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WO/2008/081568A1 |
Disclosed are: a novel dinoflagellate alga; and a macrolide compound which can be used as a novel anti-cancer agent. Specifically disclosed is a macrolide compound produced by a dinoflagellate Amphidinium sp. strain HYA002 or HYA0024. Th...
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WO/2008/082562A2 |
This invention relates to a novel antibiotic compounds, pharmaceutically acceptable salts and to methods for obtaining such compounds.
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WO/2008/072764A1 |
Disclosed is a method for producing an optically active piperidine-3-carboxylic acid compound and an optically active piperidine-3-carboxylic acid alkyl ester compound, wherein one enantiomer of a piperidine-3-carboxylic acid alkyl ester...
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WO/2008/071673A1 |
The present invention provides a polypeptide having an amino acid sequence according to SEQ ID NO 3, SEQ ID NO 6 or SEQ ID NO 43-59. The present invention also provides a polynucleotide comprising a DNA sequence encoding these polypeptid...
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WO/2008/069168A1 |
Disclosed are: a method for producing a 2-hydroxymethylpyrrolidin-3,4-diol compound or a xylulose compound which is an intermediate for the 2-hydroxymethylpyrrolidin-3,4-diol compound, and others. Specifically disclosed are a method for ...
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