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Title:
新規ピリジノン誘導体およびmGluR2ポジティブアロステリックモジュレーターとしてのその使用
Document Type and Number:
Japanese Patent JP2008513414
Kind Code:
A
Abstract:
The present invention relates to novel compounds, in particular novel pyridinone derivatives according to Formula (I) wherein all radicals are defined in the application. The compounds according to the invention are positive allosteric modulators of metabotropic receptors-subtype 2 ("mGluR2") which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions and processes to prepare such compounds and compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR2 is involved.

Inventors:
イモガイ ハッサン ジュリアン
シド ヌエス ホセ マリア
ドゥヴェイ ギラウム アルバート ジャクーズ
ボレア クリステラ マーティン
ネム ヴァンタ
フィン テリー パトリック
ル ポール エマニュエル クリスティアン
ロシャー ジェーン-フィリップ フランシス クリスティアン
ルトジェンス ロバート ヨハンス
Application Number:
JP2007531759A
Publication Date:
May 01, 2008
Filing Date:
September 16, 2005
Export Citation:
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Assignee:
ジャンセン ファーマシュウティカル エヌ ヴィ
アデックス ファーマ エス エー
International Classes:
C07D213/64; A61K31/4412; A61K31/4436; A61K31/4439; A61K31/4704; A61K31/472; A61K31/4725; A61K31/4965; A61K31/497; A61K31/506; A61K31/513; A61K31/5377; A61K31/695; A61P3/04; A61P25/00; A61P25/06; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P25/32; A61P25/34; A61P25/36; A61P43/00; C07D213/69; C07D217/24; C07D239/36; C07D241/18; C07D401/04; C07D401/10; C07D401/12; C07D405/04; C07D405/06; C07D405/12; C07D409/04; C07D409/10; C07D409/12; C07D413/06; C07D413/12; C07D417/04; C07D417/06; C07D417/12; C07F7/08; C07F7/10; C07D215/22
Domestic Patent References:
JPH02258766A1990-10-19
JPH05255258A1993-10-05
JP2004510764A2004-04-08
JPH054983A1993-01-14
JP2008502674A2008-01-31
JPH02258766A1990-10-19
JPH05255258A1993-10-05
Foreign References:
WO2003059884A12003-07-24
WO2002102807A12002-12-27
WO2001096308A12001-12-20
WO2003068750A12003-08-21
WO2004078176A12004-09-16
WO2003065994A22003-08-14
SU1796625A1
US4066651A1978-01-03
WO2003059884A12003-07-24
Other References:
JPN6011034408; Malamas, Michael S.: 'N-Substituted Spirosuccinimide, Spiropyridazine, Spiroazetidine, and Acetic Acid Aldose Reductase In' Journal of Medicinal Chemistry 37(13), 1994, p. 2059-2070
JPN6011034413; Cook, D. J.: 'Diethylaminoalkyl ester hydrochlorides of N-alkyl-4-carbostyrilcarboxylic acids' Journal of the American Chemical Society 74, 1952, p. 543-544
JPN6011034416; 中野博人: '1-Alkyl-3-phenylpyridinium塩の赤血塩酸化による1-Alkyl-2(1H)-pyridoneの3-Phenyl体と5-Phenyl体の生成比' 東北薬科大学研究年報 45, 1998, p. 145-148
Attorney, Agent or Firm:
鈴木 俊一郎
牧村 浩次
八本 佳子