Title:
新規ピリジノン誘導体およびmGluR2ポジティブアロステリックモジュレーターとしてのその使用
Document Type and Number:
Japanese Patent JP2008513414
Kind Code:
A
Abstract:
The present invention relates to novel compounds, in particular novel pyridinone derivatives according to Formula (I) wherein all radicals are defined in the application. The compounds according to the invention are positive allosteric modulators of metabotropic receptors-subtype 2 ("mGluR2") which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions and processes to prepare such compounds and compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR2 is involved.
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Inventors:
Imogai Hassan Julian
Sid Nues Jose Maria
Duvey Giraum Albert Jacques
Borea Christella Martin
Nem Vanta
Fin terry patrick
Le Paul Emmanuel Christian
Rocher Jane-Philip Francis Christian
Rutgens Robert Johans
Sid Nues Jose Maria
Duvey Giraum Albert Jacques
Borea Christella Martin
Nem Vanta
Fin terry patrick
Le Paul Emmanuel Christian
Rocher Jane-Philip Francis Christian
Rutgens Robert Johans
Application Number:
JP2007531759A
Publication Date:
May 01, 2008
Filing Date:
September 16, 2005
Export Citation:
Assignee:
Jansen Pharmaceuticals NV
ADEX Pharma SA
ADEX Pharma SA
International Classes:
C07D213/64; A61K31/4412; A61K31/4436; A61K31/4439; A61K31/4704; A61K31/472; A61K31/4725; A61K31/4965; A61K31/497; A61K31/506; A61K31/513; A61K31/5377; A61K31/695; A61P3/04; A61P25/00; A61P25/06; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P25/32; A61P25/34; A61P25/36; A61P43/00; C07D213/69; C07D217/24; C07D239/36; C07D241/18; C07D401/04; C07D401/10; C07D401/12; C07D405/04; C07D405/06; C07D405/12; C07D409/04; C07D409/10; C07D409/12; C07D413/06; C07D413/12; C07D417/04; C07D417/06; C07D417/12; C07F7/08; C07F7/10; C07D215/22
Domestic Patent References:
| JPH02258766A | 1990-10-19 | |||
| JPH05255258A | 1993-10-05 | |||
| JP2004510764A | 2004-04-08 | |||
| JPH054983A | 1993-01-14 | |||
| JP2008502674A | 2008-01-31 | |||
| JPH02258766A | 1990-10-19 | |||
| JPH05255258A | 1993-10-05 |
Foreign References:
| WO2003059884A1 | 2003-07-24 | |||
| WO2002102807A1 | 2002-12-27 | |||
| WO2001096308A1 | 2001-12-20 | |||
| WO2003068750A1 | 2003-08-21 | |||
| WO2004078176A1 | 2004-09-16 | |||
| WO2003065994A2 | 2003-08-14 | |||
| SU1796625A1 | ||||
| US4066651A | 1978-01-03 | |||
| WO2003059884A1 | 2003-07-24 |
Other References:
JPN6011034408; Ｍａｌａｍａｓ， Ｍｉｃｈａｅｌ Ｓ．: 'Ｎ-Ｓｕｂｓｔｉｔｕｔｅｄ Ｓｐｉｒｏｓｕｃｃｉｎｉｍｉｄｅ， Ｓｐｉｒｏｐｙｒｉｄａｚｉｎｅ， Ｓｐｉｒｏａｚｅｔｉｄｉｎｅ， ａｎｄ Ａｃｅｔｉｃ Ａｃｉｄ Ａｌｄｏｓｅ Ｒｅｄｕｃｔａｓｅ Ｉｎ' Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ ３７（１３）, 1994, ｐ． ２０５９-２０７０
JPN6011034413; Ｃｏｏｋ， Ｄ． Ｊ．: 'Ｄｉｅｔｈｙｌａｍｉｎｏａｌｋｙｌ ｅｓｔｅｒ ｈｙｄｒｏｃｈｌｏｒｉｄｅｓ ｏｆ Ｎ-ａｌｋｙｌ-４-ｃａｒｂｏｓｔｙｒｉｌｃａｒｂｏｘｙｌｉｃ ａｃｉｄｓ' Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ ７４, 1952, ｐ． ５４３-５４４
JPN6011034416; 中野博人: '１-Ａｌｋｙｌ-３-ｐｈｅｎｙｌｐｙｒｉｄｉｎｉｕｍ塩の赤血塩酸化による１-Ａｌｋｙｌ-２（１Ｈ）-ｐｙｒｉｄｏｎｅの３-Ｐｈｅｎｙｌ体と５-Ｐｈｅｎｙｌ体の生成比' 東北薬科大学研究年報 ４５, 1998, ｐ． １４５-１４８
JPN6011034413; Ｃｏｏｋ， Ｄ． Ｊ．: 'Ｄｉｅｔｈｙｌａｍｉｎｏａｌｋｙｌ ｅｓｔｅｒ ｈｙｄｒｏｃｈｌｏｒｉｄｅｓ ｏｆ Ｎ-ａｌｋｙｌ-４-ｃａｒｂｏｓｔｙｒｉｌｃａｒｂｏｘｙｌｉｃ ａｃｉｄｓ' Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ ７４, 1952, ｐ． ５４３-５４４
JPN6011034416; 中野博人: '１-Ａｌｋｙｌ-３-ｐｈｅｎｙｌｐｙｒｉｄｉｎｉｕｍ塩の赤血塩酸化による１-Ａｌｋｙｌ-２（１Ｈ）-ｐｙｒｉｄｏｎｅの３-Ｐｈｅｎｙｌ体と５-Ｐｈｅｎｙｌ体の生成比' 東北薬科大学研究年報 ４５, 1998, ｐ． １４５-１４８
Attorney, Agent or Firm:
Shunichiro Suzuki
Koji Makimura
Yoshiko Yamoto
Koji Makimura
Yoshiko Yamoto