Title:
標的遺伝子の発現を抑制する組成物
Document Type and Number:
Japanese Patent JP5801055
Kind Code:
B2
Abstract:
An object of the present invention is to provide a composition for suppressing expression of a target gene, and the like. A composition comprising an RNA-encapsulated liposome, wherein the RNA contains a sequence consisting of 15 to 30 contiguous bases of a target gene mRNA (hereinafter, sequence X) and a base sequence (hereinafter, complementary sequence X') complementary to the sequence X, 1 to 90% of all sugars binding to the bases of the sequence X and the complementary sequence X' being ribose substituted by a modifying group at 2' position, and the liposome being capable of reaching a tissue or an organ containing an expression site of the target gene is provide.
Inventors:
Nobuhiro Yagi
Junichi Enokien
Junichi Enokien
Application Number:
JP2010522765A
Publication Date:
October 28, 2015
Filing Date:
July 31, 2009
Export Citation:
Assignee:
Kyowa Hakko Kirin Co., Ltd.
International Classes:
A61K31/712; A61K9/127; A61K48/00; A61P29/00; A61P35/00
Foreign References:
| WO2007051303A1 | 2007-05-10 | |||
| WO2006080118A1 | 2006-08-03 |
Other References:
JPN6013046709; Ｂｉｏｃｈｅｍ Ｂｉｏｐｈｙｓ Ｒｅｓ Ｃｏｍｍｕｎ， ２００７， Ｖｏｌ．３６４， Ｎｏ．３，ｐ．４３６-４２
JPN7013003500; Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ， ２００５， Ｖｏｌ．４８， Ｎｏ．４， ｐ．９０１-９０４
JPN7013003501; ＲＮＡ，２００４， Ｖｏｌ．１０， Ｎｏ．５， ｐ．７６６-７１
JPN7013003502; ＲＮＡ， ２００３， Ｖｏｌ．９， Ｎｏ．９， ｐ．１０３４-４８
JPN7013003500; Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ， ２００５， Ｖｏｌ．４８， Ｎｏ．４， ｐ．９０１-９０４
JPN7013003501; ＲＮＡ，２００４， Ｖｏｌ．１０， Ｎｏ．５， ｐ．７６６-７１
JPN7013003502; ＲＮＡ， ２００３， Ｖｏｌ．９， Ｎｏ．９， ｐ．１０３４-４８