Login| Sign Up| Help| Contact|

Patent Searching and Data

Document Type and Number:
Japanese Patent JP5801055
Kind Code:
An object of the present invention is to provide a composition for suppressing expression of a target gene, and the like. A composition comprising an RNA-encapsulated liposome, wherein the RNA contains a sequence consisting of 15 to 30 contiguous bases of a target gene mRNA (hereinafter, sequence X) and a base sequence (hereinafter, complementary sequence X') complementary to the sequence X, 1 to 90% of all sugars binding to the bases of the sequence X and the complementary sequence X' being ribose substituted by a modifying group at 2' position, and the liposome being capable of reaching a tissue or an organ containing an expression site of the target gene is provide.

Nobuhiro Yagi
Junichi Enokien
Application Number:
Publication Date:
October 28, 2015
Filing Date:
July 31, 2009
Export Citation:
Click for automatic bibliography generation   Help
Kyowa Hakko Kirin Co., Ltd.
International Classes:
A61K31/712; A61K9/127; A61K48/00; A61P29/00; A61P35/00
Foreign References:
Other References:
JPN6013046709; Biochem Biophys Res Commun, 2007, Vol.364, No.3,p.436-42
JPN7013003500; Journal of Medicinal Chemistry, 2005, Vol.48, No.4, p.901-904
JPN7013003501; RNA,2004, Vol.10, No.5, p.766-71
JPN7013003502; RNA, 2003, Vol.9, No.9, p.1034-48