Title:
メラノーマ特異的バイオマーカー及びその利用
Document Type and Number:
Japanese Patent JPWO2016152352
Kind Code:
A1
Abstract:
メラノーマを効率よく診断するマーカー分子や、効果的な治療法に利用できる新たな治療標的分子を提供することを課題とする。メラノーマ特異的なマーカーとして、PDZRN3、DTX3L、CSS3及びBRP44Lが提供される。また、これらの生体分子を利用した検査法、治療法などが提供される。
Inventors:
Masashi Kato
Ichiro Yajima
Takeda Hushu Megumi
Yuji Goto
Ichiro Yajima
Takeda Hushu Megumi
Yuji Goto
Application Number:
JP2017507616A
Publication Date:
January 11, 2018
Filing Date:
February 20, 2016
Export Citation:
Assignee:
Nagoya University
Chubu University
Chubu University
International Classes:
C12Q1/04; A61K31/7105; A61K31/713; A61K35/76; A61K38/00; A61K45/00; A61K48/00; A61P17/00; A61P35/00; A61P43/00; C12N15/09; C12N15/113; G01N33/53
Domestic Patent References:
| JP2011520451A | 2011-07-21 |
Foreign References:
| WO2013192616A1 | 2013-12-27 |
Other References:
YAJIMA, I. ET AL.: "Functional analysis of GNG2 in human malignant melanoma cells", JOURNAL OF DERMATOLOGICAL SCIENCE, vol. 68, JPN6019048374, 2012, pages 172 - 178, XP055317739, ISSN: 0004314584, DOI: 10.1016/j.jdermsci.2012.09.009
DENTE, L. ET AL.: "Cloning and developmental expression of zebrafish pdzrn3", THE INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, vol. 55, JPN6019048375, 15 December 2011 (2011-12-15), pages 989 - 993, XP055317704, ISSN: 0004314585, DOI: 10.1387/ijdb.113437ld
YAJIMA, I. ET AL.: "Reduced GNG2 expression levels in mouse malignant melanomas and human melanoma cell lines", AM J CANCER RES, vol. 2, no. 3, JPN6019048377, 2012, pages 322 - 329, XP055317709, ISSN: 0004314586
DENTE, L. ET AL.: "Cloning and developmental expression of zebrafish pdzrn3", THE INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, vol. 55, JPN6019048375, 15 December 2011 (2011-12-15), pages 989 - 993, XP055317704, ISSN: 0004314585, DOI: 10.1387/ijdb.113437ld
YAJIMA, I. ET AL.: "Reduced GNG2 expression levels in mouse malignant melanomas and human melanoma cell lines", AM J CANCER RES, vol. 2, no. 3, JPN6019048377, 2012, pages 322 - 329, XP055317709, ISSN: 0004314586
Attorney, Agent or Firm:
Mikiharu Hagino
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