Title:
ベンゾイルグリシン誘導体およびその作製および使用の方法
Document Type and Number:
Japanese Patent JP7012289
Kind Code:
B2
Abstract:
Disclosed are compounds of formulae:and pharmaceutically acceptable salts thereof, wherein the variables, R1, R2, R3, R4, R5, R6, R7, R11, R12, R13, R14, R15, R16, R17, n, and m are defined herein. These compounds are useful for treating Gram-negative bacteria infections. Also disclosed are methods of making these compounds.
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Inventors:
Robert A. Nicholas
Liang Xiaofei
Pei butterfly
Eric Jay Toon
Ramesh Gopalaswamy
Frank Navas, The Third
Liang Xiaofei
Pei butterfly
Eric Jay Toon
Ramesh Gopalaswamy
Frank Navas, The Third
Application Number:
JP2018556890A
Publication Date:
February 14, 2022
Filing Date:
April 25, 2017
Export Citation:
Assignee:
Duke University
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
International Classes:
C07C259/06; A61K31/198; A61K31/396; C07C229/22; C07C311/06; C07D309/06
Domestic Patent References:
| JP51076220A | ||||
| JP2012502946A | ||||
| JP2010280684A | ||||
| JP62255460A | ||||
| JP2010530372A |
Foreign References:
| WO2015024011A1 | ||||
| US20150225388 | ||||
| WO2014165075A1 | ||||
| WO2015024010A1 | ||||
| WO2012031298A1 | ||||
| WO2013170030A1 |
Other References:
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SOLOSHONOK, V. et al.,Transition metal/base-catalyzed aldol reactions of isocyanoacetic acid derivatives with prochiral ketones, a straightforward approach to stereochemically defined β,β-disubstituted-β-hydroxy-α-amino acids. Scope and limitations,J. Org. Chem.,1997年,Vol.62,pp.3470-3479
SOLOSHONOK, V. A. et al.,Transition metal-catalyzed diastereoselective aldol reactions of prochiral ketones with methyl isocyanoacetate,Tetrahedron Letters,1996年,Vol.37, No.43,pp.7845-7848
LEE, C. J. et al.,Drug design from the cryptic inhibitor envelope,NATURE COMMUNICATIONS,2016年,pp.1-7,Supplementary Data,doi:10.1038/ncomms10638
Registry(STN)[online],2015年12月03日,CAS登録番号 1822350-04-8
SOLOSHONOK, V. et al.,Transition metal/base-catalyzed aldol reactions of isocyanoacetic acid derivatives with prochiral ketones, a straightforward approach to stereochemically defined β,β-disubstituted-β-hydroxy-α-amino acids. Scope and limitations,J. Org. Chem.,1997年,Vol.62,pp.3470-3479
SOLOSHONOK, V. A. et al.,Transition metal-catalyzed diastereoselective aldol reactions of prochiral ketones with methyl isocyanoacetate,Tetrahedron Letters,1996年,Vol.37, No.43,pp.7845-7848
LEE, C. J. et al.,Drug design from the cryptic inhibitor envelope,NATURE COMMUNICATIONS,2016年,pp.1-7,Supplementary Data,doi:10.1038/ncomms10638
Registry(STN)[online],2015年12月03日,CAS登録番号 1822350-04-8
Attorney, Agent or Firm:
Aoki Atsushi
Shinji Mihashi
Youichi Watanabe
Nakajima Masaru
Ryotaro Takei
Michiko Uehara
Shinji Mihashi
Youichi Watanabe
Nakajima Masaru
Ryotaro Takei
Michiko Uehara