To provide a biomaterial of an artificial bone-cartilage complex type for which self-organizing cartilage-like biomaterial and an artificial bone are united.
The biomaterial of artificial bone-cartilage complex type can be successfully produced by contacting glycosaminoglycan, proteoglycan and collagen, which are components of a cartilage-like complex, with an artificial bone and allowing the self-organization of the complex based on the artificial bone. This complex type biomaterial is a biomaterial that is usable in reconstructing a joint tissue with the integration of the bone tissue, i.e., the skeleton and the cartilage tissue side, i.e., the movable face of the joint in any bone-cartilage lesion accompanied by the degeneration or fracture of joint such as rheumatoid arthritis, degenerative joint disease, bone fracture, bone tumor and so on.
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Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue
Masato Ozeki
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