Title:
COMBINATION COMPRISING S-[2-([[1-(2-ETHYLBUTYL)CYCLOHEXYL]CARBONYL]AMINO)PHENYL] 2-METHYLPROPANETHIOATE AND HMG-COA REDUCTASE INHIBITOR
Document Type and Number:
Japanese Patent JP2012107018
Kind Code:
A
Abstract:
To provide a combination and pharmaceutical composition for the treatment or prophylaxis of circulatory disorders in a patient, such as hyperlipemia, coronary heart disease, and atherosclerosis in particular.
There are provided a combination, a pharmaceutical composition, a package and a kit comprising (a) S-[2-([[1-(2-ethylbutyl)cyclohexyl]carbonyl]amino)phenyl]2-methylpropanethioate or prodrug of the active form thereof, and (b) at least one HMG-CoA reductase inhibitor, and a method for the treatment and prophylaxis.
Inventors:
URATA YASUO
HOSHINO SHOJI
KAWAMURA HITOSHI
OKAMOTO HIROSHI
FURUKAWA NOBORU
HOSHINO SHOJI
KAWAMURA HITOSHI
OKAMOTO HIROSHI
FURUKAWA NOBORU
Application Number:
JP2011284636A
Publication Date:
June 07, 2012
Filing Date:
December 27, 2011
Export Citation:
Assignee:
JAPAN TOBACCO INC
International Classes:
A61K31/167; A61K31/22; A61K31/225; A61K31/325; A61K31/366; A61K31/40; A61K31/401; A61K31/404; A61K31/47; A61K31/505; A61K45/00; A61K45/06; A61P3/00; A61P3/06; A61P3/10; A61P9/00; A61P9/10; A61P43/00
Domestic Patent References:
| JPH1149743A | 1999-02-23 |
Foreign References:
| WO2000038722A1 | 2000-07-06 | |||
| WO2002013797A2 | 2002-02-21 |
Other References:
JPN7010002840; Ｃｕｒｒｅｎｔ ｏｐｉｎｉｏｎ ｉｎ ｉｎｖｅｓｔｉｇａｔｉｏｎａｌ ｄｒｕｇｓ Ｍａｒ． ２００３， Ｖｏｌ．４， Ｎｏ．３, ｐａｇｅｓ ２９１-２９７
JPN7010002841; Ｅｘｐｅｒｔ ｏｐｉｎｉｏｎ ｏｎ ｅｍｅｒｇｉｎｇ ｄｒｕｇｓ ２００３， Ｖｏｌ．８， Ｎｏ．２, ｐａｇｅｓ ３６５-３７６
JPN7010002842; Ｅｕｒｏｐｅａｎ ｊｏｕｒｎａｌ ｏｆ ｐｈａｒｍａｃｏｌｏｇｙ １１ｔｈ Ａｐｒ． ２００３， Ｖｏｌ．４６６， Ｎｏ．１-２, ｐａｇｅｓ １４７-１５４
JPN6010052238; Ｃｉｒｃｕｌａｔｉｏｎ ２００２， Ｖｏｌ．１０５, ｐａｇｅｓ ２１５９-２１６５
JPN6010052241; Ｎａｔｕｒｅ（Ｌｏｎｄ） ２０００， Ｖｏｌ．４０６， Ｎｏ．６７９２, ｐａｇｅｓ ２０３-２０７
JPN7010002841; Ｅｘｐｅｒｔ ｏｐｉｎｉｏｎ ｏｎ ｅｍｅｒｇｉｎｇ ｄｒｕｇｓ ２００３， Ｖｏｌ．８， Ｎｏ．２, ｐａｇｅｓ ３６５-３７６
JPN7010002842; Ｅｕｒｏｐｅａｎ ｊｏｕｒｎａｌ ｏｆ ｐｈａｒｍａｃｏｌｏｇｙ １１ｔｈ Ａｐｒ． ２００３， Ｖｏｌ．４６６， Ｎｏ．１-２, ｐａｇｅｓ １４７-１５４
JPN6010052238; Ｃｉｒｃｕｌａｔｉｏｎ ２００２， Ｖｏｌ．１０５, ｐａｇｅｓ ２１５９-２１６５
JPN6010052241; Ｎａｔｕｒｅ（Ｌｏｎｄ） ２０００， Ｖｏｌ．４０６， Ｎｏ．６７９２, ｐａｇｅｓ ２０３-２０７
Attorney, Agent or Firm:
Takashima Ichi
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Kenji Yamamoto
Murata Miyuki
Junzo Koike
Hirofumi Toma
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Kenji Yamamoto
Murata Miyuki
Junzo Koike
Hirofumi Toma
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