To provide antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9), the antibodies being directed to peptides, in which the antibodies bind to PCSK9; and to provide a method of obtaining such antibodies and antibody-encoding nucleic acid.
This invention relates to: an isolated anti-PCSK9 antibody which specifically binds to PCSK9 and which is a full antagonist of the PCSK9-mediated effect on LDLR levels when measured in vitro using the LDLR down regulation assay in Huh7 cells; and therapeutic methods for use of these antibodies and antigen-binding portions thereof to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease, including treatment of hypercholesterolemia.
ABDICHE YASMINA NOUBIA
CHAPARRO RIGGERS JAVIER FERNANDO
GOMES BRUCE CHARLES
HAWKINS JULIE JIA LI
PONS JAUME
QIU XIAYANG
STROP PAVEL
WANG YULI
PFIZER
| WO2008057457A2 | 2008-05-15 | |||
| WO2008057458A2 | 2008-05-15 | |||
| WO2008057459A2 | 2008-05-15 | |||
| WO2008063382A2 | 2008-05-29 |
High Hoji Koji
Junko Miyazawa
Noh four
Maki Sato
Tatsuta Miyuki