Title:
COMPOSITIONS OF MGD-CSF IN DISEASE TREATMENT AND USE METHODS THEREOF
Document Type and Number:
Japanese Patent JP2016146850
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide compositions of MGD-CSF in disease treatment and use methods thereof.SOLUTION: Disclosed is a newly identified secreted molecule, identified herein as "monocyte, granulocyte, and dendritic cell colony stimulating factor" (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion protein. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss.SELECTED DRAWING: None
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Inventors:
BEHRENS DIRK
BOSCH ELIZABETH
DOBERSTEIN STEPHEN
HALENBECK ROBERT FORGAN
HESTIR KEVIN
HUANG MIN MEI
ERNESTINE LEE
LIN HAISHAN
LINNEMANN THOMAS
SHANNON MARSHALL
JUSTIN G P WONG
WU GE
AILEEN ZHOU
WILLIAMS LEWIS T
CINDY LEO
BOSCH ELIZABETH
DOBERSTEIN STEPHEN
HALENBECK ROBERT FORGAN
HESTIR KEVIN
HUANG MIN MEI
ERNESTINE LEE
LIN HAISHAN
LINNEMANN THOMAS
SHANNON MARSHALL
JUSTIN G P WONG
WU GE
AILEEN ZHOU
WILLIAMS LEWIS T
CINDY LEO
Application Number:
JP2016103092A
Publication Date:
August 18, 2016
Filing Date:
May 24, 2016
Export Citation:
Assignee:
FIVE PRIME THERAPEUTICS INC
International Classes:
C12N15/09; A01K67/027; A61K31/7088; A61K31/7105; A61K31/713; A61K35/12; A61K35/17; A61K35/76; A61K38/00; A61K39/00; A61K39/395; A61K48/00; A61P1/04; A61P1/16; A61P9/00; A61P9/10; A61P15/00; A61P17/06; A61P19/02; A61P25/00; A61P29/00; A61P31/04; A61P31/10; A61P31/12; A61P33/00; A61P35/00; A61P35/02; A61P37/04; C07K14/47; C07K16/18; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/113; C12P21/02; C12Q1/68; G01N33/15; G01N33/50; G01N33/53
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita
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