Title:
シクロプロパン化合物及びその医薬用途
Document Type and Number:
Japanese Patent JP2007516982
Kind Code:
A
Abstract:
The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): wherein R1 is —(CH2)m—X—(CH2)n-A1 etc., wherein m and n are the same or different and each is 0 to 6, X is a single bond, etc. and A1 is a substituted C3-14 hydrocarbon ring group, etc.; R2 and R3 are the same or different and each is a hydrogen atom, —(CH2)p—X1—(CH2)q-A2, etc., wherein p and q are the same or different and each is 0 to 6, X1 is a single bond, etc. and A2 is an optionally substituted C3-14 hydrocarbon ring group, etc.; R4 is —CO2R9, etc., wherein R9 is a hydrogen atom, etc.; and R20 and R21 are the same or different and each is a hydrogen atom, —(CH2)m12—X12—(CH2)m12—R30, etc., wherein m12 and m12 are the same or different and each is 0 to 6, X12 is a single bond, etc. and R30 is a hydrogen atom, etc.; or a prodrug thereof or a pharmaceutically acceptable salt thereof.
Inventors:
Takayuki Inaba
Hearth Julia
Makoto Shiozaki
Littman Nicole M
Katsuhisa Yasue
Andrews Stephen W
Atsushi Sakai
Flyer Andrew M
Takafumi Matsuo
Laird Ellen Earl
Suma Yo
Yuichi Shinozaki
Yoshikazu Hori
Hiroto Imai
Yu Negoro
Hearth Julia
Makoto Shiozaki
Littman Nicole M
Katsuhisa Yasue
Andrews Stephen W
Atsushi Sakai
Flyer Andrew M
Takafumi Matsuo
Laird Ellen Earl
Suma Yo
Yuichi Shinozaki
Yoshikazu Hori
Hiroto Imai
Yu Negoro
Application Number:
JP2006545808A
Publication Date:
June 28, 2007
Filing Date:
December 14, 2004
Export Citation:
Assignee:
Japan Tobacco Inc.
International Classes:
C07C311/20; A61K31/18; A61K31/196; A61K31/27; A61K31/343; A61K31/381; A61K31/397; A61K31/40; A61K31/4025; A61K31/4035; A61K31/41; A61K31/415; A61K31/4155; A61K31/4164; A61K31/417; A61K31/4184; A61K31/4192; A61K31/42; A61K31/422; A61K31/4245; A61K31/426; A61K31/427; A61K31/429; A61K31/433; A61K31/437; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4418; A61K31/4436; A61K31/4439; A61K31/445; A61K31/4465; A61K31/4468; A61K31/4535; A61K31/455; A61K31/472; A61K31/473; A61K31/495; A61K31/496; A61K31/498; A61K31/4985; A61K31/50; A61K31/501; A61K31/506; A61K31/519; A61K31/53; A61K31/5375; A61K31/5377; A61K31/541; A61K31/55; A61K31/551; A61P19/02; A61P29/00; A61P43/00; C07C311/13; C07C311/22; C07C311/29; C07C311/36; C07C311/46; C07D205/04; C07D207/08; C07D207/12; C07D207/48; C07D209/44; C07D211/14; C07D211/34; C07D211/58; C07D211/96; C07D213/18; C07D213/30; C07D213/36; C07D213/65; C07D213/71; C07D213/74; C07D213/81; C07D213/82; C07D217/04; C07D217/08; C07D217/16; C07D231/12; C07D231/18; C07D233/54; C07D233/60; C07D233/64; C07D235/18; C07D237/12; C07D237/20; C07D239/22; C07D239/42; C07D241/04; C07D241/38; C07D241/50; C07D243/08; C07D257/04; C07D261/08; C07D261/20; C07D263/58; C07D265/30; C07D271/06; C07D271/10; C07D271/107; C07D277/20; C07D277/26; C07D277/36; C07D277/82; C07D285/125; C07D295/08; C07D295/22; C07D295/26; C07D307/79; C07D307/81; C07D307/91; C07D333/06; C07D333/18; C07D333/34; C07D333/36; C07D333/38; C07D333/40; C07D333/54; C07D333/62; C07D401/04; C07D403/04; C07D409/04; C07D409/12; C07D409/14; C07D413/04; C07D413/12; C07D413/14; C07D417/04; C07D417/12; C07D419/04; C07D419/14; C07D471/04; C07D487/04; C07D513/04; C07D513/06
Domestic Patent References:
| JP2005504026A | 2005-02-10 | |||
| JP2005502632A | 2005-01-27 | |||
| JP2005504021A | 2005-02-10 | |||
| JP2004530691A | 2004-10-07 | |||
| JP2000319250A | 2000-11-21 | |||
| JP2005504026A | 2005-02-10 | |||
| JP2005502632A | 2005-01-27 | |||
| JP2005504021A | 2005-02-10 | |||
| JP2004530691A | 2004-10-07 | |||
| JP2000319250A | 2000-11-21 |
Other References:
JPN6010002733, Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ, 1993, ３（４）, ｐ．６６７−６７０
JPN6010002731, Ｈｅｔｅｒｏｃｙｃｌｅｓ, 1987, ２６（１０）, ｐ．２５７９−２５８１
JPN6010002731, Ｈｅｔｅｒｏｃｙｃｌｅｓ, 1987, ２６（１０）, ｐ．２５７９−２５８１
Attorney, Agent or Firm:
Ryu Iwatani