DEVICE AND METHOD FOR GENE DIAGNOSIS

Japanese Patent JP3781689

B2

PROBLEM TO BE SOLVED: To provide a device and a method for gene diagnosis capable of easily and accurately detecting a gene aberration of one base or more in a short time and reducing the size, weight, and costs of the device for automating the diagnosis at a low running cost.
SOLUTION: In this gene diagnosis device, a separating DNA conjugate, in which a base sequence and a polymer compound bondable with a DNA sample via hydrogen bonds are bonded for separating the DNA sample between a normal DNA, an abnormal DNA, and a noise DNA according to a difference of bonding strength, and the DNA sample are arranged in a buffer solution inside a sealed flow passage. When an absolute value of voltage is increased, the DNA sample inside the sealed flow passage is electrophoresed, and a passage amount of the normal DNA and that of the abnormal DNA are measured respectively by means of a detection part.

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Kazuyoshi Mori
Hideaki Hashimoto
Takeshi Nishida
Mizuo Maeda
Yoshiki Katayama

JP2002042943A

May 31, 2006

February 20, 2002

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Matsushita Electric Industrial Co., Ltd
Mizuo Maeda
Yoshiki Katayama

G01N27/447; G01N33/483; C12M1/00; C12M1/34; C12M1/38; C12M1/42; C12N15/09; C12Q1/68; G01N33/50; (IPC1-7): G01N27/447; C12M1/00; C12M1/34; C12M1/38; C12M1/42; C12N15/09; C12Q1/68; G01N33/483; G01N33/50

JP2001252098A
JP6138090A
JP5332992A

有澤卓己,キャピラリー電気泳動による遺伝子変異診断法の開発,九州大学大学院工学研究科 材料物性工学専攻 前田研究室 卒業論文,日本,2000年 3月
穴田貴久,DNAコンジュゲートを用いる遺伝子一塩基変位診断システムの開発,日本分析化学会第49年会講演要旨集,日本,2000年 9月,p.180

Fumio Iwahashi
Daisuke Nagano
Hiroki Naito

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