Title:
DIFFERENTIATION-INDUCING AGENT
Document Type and Number:
Japanese Patent JP3354090
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain a new benzamide derivative having differentiation inducing acton, useful as a medicine for treating and improving malignant tumor, autoimmune disease, dermatitis and parasitic infectious disease.
SOLUTION: This compound is shown by formula I {A is a (substituted) phenyl or a heterocycle (which may contain 1 to 4 substituent groups such as a halogen, hydroxyl group, amino, nitro and cyano); X is a direct bond, (CH2)e, (CH2)g-O-(CH2)e, etc. ((e) is 1-4; (g) is 0-4); Q is a structure shown by formula II [R7 is H, a 1-4C (substituted) alkyl], etc.; R1 and R2 are each H, a halogen, etc.; R3 is a hydroxyl group or amino}. The compound of formula I is obtained, for example, by subjecting a compound of the formula A-X-R9 [R9 is C(=G)OH (G is oxygen or sulfur) or NH2] and a compound of formula III [R9 and R10 are not the same and one is C(=G)OH and the other is NH2; R11 is a protected hydroxyl group] to condensation reaction.
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Inventors:
Tsuneji Suzuki
Tomoyuki Ando
Katsutoshi Tsuchiya
Osamu Nakanishi
Akiko Saito
Shun Yamashita
Gongo Shiraishi
Eiji Tanaka
Tomoyuki Ando
Katsutoshi Tsuchiya
Osamu Nakanishi
Akiko Saito
Shun Yamashita
Gongo Shiraishi
Eiji Tanaka
Application Number:
JP26027797A
Publication Date:
December 09, 2002
Filing Date:
September 25, 1997
Export Citation:
Assignee:
Schering Actien Gezel Shaft
International Classes:
A61K31/165; A61K31/167; A61K31/17; A61K31/27; A61K31/275; A61K31/38; A61K31/381; A61K31/415; A61K31/4166; A61K31/42; A61K31/421; A61K31/425; A61K31/426; A61K31/44; A61K31/4418; A61K31/4427; A61K31/443; A61K31/4433; A61K31/445; A61K31/495; A61K31/496; A61K31/505; A61P17/00; A61P33/00; A61P35/00; A61P35/02; A61P37/00; A61P43/00; C07C237/42; C07C255/31; C07C271/18; C07C271/40; C07C275/24; C07C275/28; C07C323/52; C07C323/62; C07C327/48; C07C335/16; C07D207/34; C07D209/42; C07D211/24; C07D213/30; C07D213/40; C07D213/56; C07D213/65; C07D213/70; C07D213/74; C07D213/75; C07D213/81; C07D213/82; C07D233/34; C07D233/42; C07D233/64; C07D239/28; C07D241/14; C07D261/08; C07D261/10; C07D263/48; C07D275/02; C07D277/20; C07D277/24; C07D277/40; C07D307/12; C07D307/68; C07D307/84; C07D333/16; C07D333/38; C07D333/62; C07D295/08; C07D401/06; C07D401/12; C07D405/12; C07D409/12; C07D413/12; C07D453/02; C07D491/048; C07D495/04; C07D521/00; (IPC1-7): C07C237/42; A61K31/167; A61K31/17; A61K31/27; A61K31/275; A61K31/38; A61K31/415; A61K31/42; A61K31/425; A61K31/44; A61K31/445; A61K31/495; A61K31/505; A61P17/00; A61P33/00; A61P35/00; A61P35/02; A61P37/00; A61P43/00; C07C255/31; C07C271/18; C07C271/40; C07C275/24; C07C275/28; C07C323/52; C07C323/62; C07C327/48; C07C335/16; C07D207/34; C07D209/42; C07D211/24; C07D213/30; C07D213/40; C07D213/56; C07D213/65; C07D213/70; C07D213/74; C07D213/75; C07D213/81; C07D213/82; C07D233/34; C07D233/42; C07D233/64; C07D239/28; C07D241/14; C07D261/08; C07D261/10; C07D263/48; C07D275/02; C07D277/24; C07D277/40; C07D295/08; C07D307/12; C07D307/68; C07D307/84; C07D333/16; C07D333/38; C07D333/62; C07D401/06; C07D401/12; C07D405/12; C07D409/12; C07D413/12; C07D453/02; C07D491/048; C07D495/04; C07D521/00
Domestic Patent References:
| JP9511764A |
Other References:
【文献】国際公開97/24328(WO,A1)
【文献】Chemical Abstracts,Vol.63(1965),abstract No.18311g
【文献】Chemical Abstracts,Vol.63(1965),abstract No.18311g
Attorney, Agent or Firm:
Takashi Ishida (4 others)