Title:
凝固因子阻害剤としてのジペプチド類似体
Document Type and Number:
Japanese Patent JP5318094
Kind Code:
B2
Abstract:
Disclosed are novel dipeptide analogs compounds of Formula (I), (II) or (III): or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a solvate, or a prodrug thereof, which are inhibitors of factor XIa and/or plasma kallikrein, compositions containing them, and methods of using them, for example, for the treatment or prophylaxis of thrombotic diseases.
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Inventors:
Donald Jay P. Pinto
Mimi El Kwan
Leon M Smith the Second
Michael Jay Owat
Paul Jay Gilligan
Mimi El Kwan
Leon M Smith the Second
Michael Jay Owat
Paul Jay Gilligan
Application Number:
JP2010512311A
Publication Date:
October 16, 2013
Filing Date:
June 11, 2008
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
C07D257/04; A61K31/167; A61K31/41; A61K31/4155; A61K31/4178; A61K31/4196; A61K31/423; A61K31/4245; A61K31/427; A61K31/428; A61K31/433; A61K31/437; A61K31/4439; A61K31/454; A61K31/4709; A61K31/4725; A61K31/496; A61K31/497; A61K31/498; A61K31/501; A61K31/506; A61K31/5365; A61K31/5377; A61K31/5383; A61K31/541; A61K31/5415; A61K31/55; A61K31/5513; A61P7/02; A61P9/00; A61P9/10; C07D401/12; C07D401/14; C07D403/12; C07D405/12; C07D409/12; C07D413/12; C07D417/12; C07D417/14; C07D471/04; C07D487/04; C07D498/04; C07F9/6524
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Foreign References:
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Other References:
Bioorganic and Medicinal Chemistry Letters ,2002年,12(20),2969-2971
Bioorganic and Medicinal Chemistry Letters,2007年,17(9),2448-2451
Journal of Medicinal Chemistry ,2005年,48(13),4469-4473
Chinese Pharmaceutical Journal (Taipei, Taiwan) ,2006年,58(1),19-34
Khimiya Geterotsiklicheskikh Soedinenii ,1985年,(9),1202-6
Bioorganic and Medicinal Chemistry Letters,2007年,17(9),2448-2451
Journal of Medicinal Chemistry ,2005年,48(13),4469-4473
Chinese Pharmaceutical Journal (Taipei, Taiwan) ,2006年,58(1),19-34
Khimiya Geterotsiklicheskikh Soedinenii ,1985年,(9),1202-6
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Shinichiro Yamanaka
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Shinichiro Yamanaka