Title:
フィードバック耐性メバロン酸キナーゼ
Document Type and Number:
Japanese Patent JP4643569
Kind Code:
B2
Abstract:
The present invention relates to modified mevalonate kinases that are less sensitive to feedback inhibition, and to polynucleotides encoding them. The invention further pertains to vectors comprising these polynucleotides and host cells containing such vectors. The invention provides a method for producing the modified enzyme and a method for producing isoprenoid compounds.
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Inventors:
Bai, Reninan
Humblen, Marx
Lehman, Martin
Lopez-Uliveri, Luar
Vis, Marx
Humblen, Marx
Lehman, Martin
Lopez-Uliveri, Luar
Vis, Marx
Application Number:
JP2006515622A
Publication Date:
March 02, 2011
Filing Date:
June 10, 2004
Export Citation:
Assignee:
DSM IP ASSETS B.V.
International Classes:
C12N9/12; C12N15/09; C12N15/54; C12P23/00; C12Q1/48
Other References:
Gene,2002年,Vol.297,p.129-139
Eur.J.Hum.Genet.,2001年,Vol.9,p.253-259
Eur.J.Hum.Genet.,2001年,Vol.9,p.260-266
Eur.J.Hum.Genet.,2001年,Vol.9,p.253-259
Eur.J.Hum.Genet.,2001年,Vol.9,p.260-266
Attorney, Agent or Firm:
Yuichi Yamada
Masakazu Noda
Yoshinori Shimizu
Masakazu Noda
Yoshinori Shimizu