生体高分子を認識するハイブリッド型蛍光プローブ

Japanese Patent JP7264344

B2

To provide a method capable of quantitatively and highly sensitively analyzing biopolymers containing saccharides, particularly oligosaccharides.SOLUTION: It is discovered that: a substituent which increases water solubility is introduced into a mother skeleton of BODIPY (boron-dipyrromethene) which is a type of fluorescent dye used for protein analysis, further a substituted aryl group is introduced at a 5-position of the dipyrromethene skeleton; then, BODIPY, which is known to emit almost no fluorescence in an aqueous solution, causes a decrease in polarity around a molecule when it binds to an oligosaccharide, and in response to the decrease in polarity, it emits strong and dramatically stable fluorescence in an aqueous solution. Further, it becomes possible to introduce a saccharide-selective functional group as a substituent of an aryl group. Thus, a hybrid fluorescent probe which is highly sensitive and can be selective for various saccharides is provided.SELECTED DRAWING: None

WO/2003/106668	GLUCOSE DEHYDROGENASE
WO/1998/037222	METHOD FOR REVERSIBLE IMMOBILIZING OLIGO- AND/OR POLYSACCHARIDES
JP2002524735	[Title of Invention] Module for computer interface

Date Takao
Ryo Watanabe
Ryota Naka
柏▲崎▼ 玄伍
Takashi Kitayama

JP2019034085A

April 25, 2023

February 27, 2019

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Fukui Prefectural University
Kinki University

G01N33/66; C07F5/02; C09B23/14; C09B57/00; C09K11/06; G01N21/64

JP2017518261A
JP2015512955A

WO2015148915A1
WO2018217266A1

中尾圭佑,異なる反応活性基をもつ糖のクリックケミストリー,日本農芸化学会大会講演要旨集,日本農芸化学会,2011年03月05日,2011,307

Yamato Kento
Shinagawa
Masahiro Suwon
Futami Kamahira

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