Title:
HYDROCINNAMIC ACID DERIVATIVE
Document Type and Number:
Japanese Patent JPS6447748
Kind Code:
A
Abstract:
NEW MATERIAL: The compd. of formula I [one or two of R1 to R4 are halogen, methoxy and the others are H; R5 is H or phenyl; R6 is OR12 or NR13R14 (R12 is H, 1 to 10C alkyl, etc.; R13 is H or 1 to 4C alkyl,; R14 is H, pyridyl, etc.); R7 is 1 to 4C alkyl, etc.; R8, R9 are H or 1 to 4C alkyl; R10 is H; R11 is hydroxy or oxo by bonding].
EXAMPLE: Ethyl N-[2-(4-acetoamidebutyl)-5-chlorohydrocinnamoyl)glycinate.
USE: A medicine for control and prevention of cerebral insufficiency and a medicine for improving cognition functions.
PROCESS: The compd. of the formula I is obtd. by processing the benzazecinedione of formula II in the presence of the compd. of formula HOR12↑' (R12↑' is H, 1 to 10C alkyl) at room temp. by using an acid, such as concd. hydrochloric acid.
Inventors:
BERUNAA ATSUSHIYUBANDEN
RUNE IMUHOFU
ROORANTO YAKOPUURETONE
EMIRIO KIBURUTSU
Application Number:
JP17930088A
Publication Date:
February 22, 1989
Filing Date:
July 20, 1988
Assignee:
HOFFMANN LA ROCHE
International Classes:
A61K31/165; A61K31/325; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4418; A61K31/445; A61K31/47; A61K31/473; A61P25/28; C07C67/00; C07C231/00; C07C231/02; C07C231/12; C07C233/47; C07C235/52; C07C237/12; C07C237/20; C07C237/22; C07D221/10; C07C237/36; C07C239/00; C07C275/24; C07D213/30; C07D213/75; C07D213/81; C07D225/06; C07D295/13; C07D295/185; (IPC1-7): A61K31/165; A61K31/325; A61K31/44; A61K31/445; A61K31/47; C07C102/00; C07C103/183; C07C103/38; C07C103/42; C07C103/46; C07C103/49; C07C103/50; C07C103/76; C07C125/065; C07C127/17; C07D211/28; C07D213/30; C07D213/75; C07D221/10; C07D225/06
Attorney, Agent or Firm:
Heikichi Odashima
