Title:
【発明の名称】酵素インヒビターとしての芳香族ヘテロ環誘導体
Document Type and Number:
Japanese Patent JPH10510539
Kind Code:
A
Abstract:
The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.
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Inventors:
Tamura, Susan Yoshiko
Semple, Joseph Edward
Lipka, William Charles
Ardley, robert john
Gee, You
Carpenter, Stephen H.
Brunnuk, Terence Kevin
Rim-Wilby, Margarita Es.
Nut, Ruth F.
Abelman, Matthew Mark
Semple, Joseph Edward
Lipka, William Charles
Ardley, robert john
Gee, You
Carpenter, Stephen H.
Brunnuk, Terence Kevin
Rim-Wilby, Margarita Es.
Nut, Ruth F.
Abelman, Matthew Mark
Application Number:
JP51929096A
Publication Date:
October 13, 1998
Filing Date:
December 13, 1995
Export Citation:
Assignee:
Corbus International, Incorporated
International Classes:
A61K31/44; A61K31/495; A61K31/505; A61P7/02; A61P43/00; C07C257/18; C07C279/24; C07C279/34; C07C281/06; C07C311/54; C07C327/48; C07D211/56; C07D211/76; C07D213/75; C07D213/76; C07D239/46; C07D239/47; C07D239/52; C07D239/545; C07D401/12; C07F7/18; C07K5/06; C07K5/078; A61K38/00; C07D239/54; (IPC1-7): C07D213/76; C07D239/46; C07D239/47; C07D239/52
Attorney, Agent or Firm:
Shusaku Yamamoto