Title:
【発明の名称】G-蛋白(RGS4)の構造ならびにそれを用いるアゴニストおよびアンタゴニストの同定方法
Document Type and Number:
Japanese Patent JP2003532741
Kind Code:
A
Abstract:
The present invention provides a solution structure of free RGS4 determined using NMR techniques. The structure includes a Galpha binding site and an allosteric binding site. The structural information provided can be employed to identify, select or design agonists and antagonists of RGS4 activity. The invention includes two dimensional and three dimensional models and representations of the structure of free RGS4 based upon structural coordinates that are provided that are useful in the methods described.
Inventors:
Robert Powers
Franklin Moy
Pranab Kay Chanda
Mark eye coquette
Philip Jones
Kimberly Mason
Simon Seamouth
Kathleen H. Young
David Shuey
Franklin Moy
Pranab Kay Chanda
Mark eye coquette
Philip Jones
Kimberly Mason
Simon Seamouth
Kathleen H. Young
David Shuey
Application Number:
JP2001582368A
Publication Date:
November 05, 2003
Filing Date:
May 09, 2001
Export Citation:
Assignee:
Wyeth
International Classes:
C07K14/47; G01N33/15; G01N33/48; G01N33/50; (IPC1-7): C07K14/47; G01N33/15; G01N33/50
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)