Title:
【発明の名称】オリゴデンドログリア増殖因子およびその利用法
Document Type and Number:
Japanese Patent JPH08508014
Kind Code:
A
Abstract:
A 60 kilodalton protein ("oligodendroglial trophic factor", OTF) induces the accumulation of oligodendroglia in cultures of cerebral white matter. Half-maximal oligodendroglial recruitment is obtained with 2 ng/mL of oligodendroglial trophic factor. Oligodendroglial trophic factor is a mitogen for oligodendroglial progenitor cells and oligodendroglia, but does not stimulate proliferation of astroglia, Schwann cells, or endoneurial fibroblasts. Immunohistological studies with a monoclonal oligodendroglial trophic factor antibody indicate that oligodendroglial trophic factor is expressed by neurons in CNS and dorsal root ganglia.
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Inventors:
Crader, Barbara Kew
Pleasure, David
Lee, Virginia M-Wye
Pleasure, David
Lee, Virginia M-Wye
Application Number:
JP52033894A
Publication Date:
August 27, 1996
Filing Date:
March 11, 1994
Export Citation:
Assignee:
The Children's Hospital of Philadelphia
The Trustees of the University of Pennsylvania
The Trustees of the University of Pennsylvania
International Classes:
C12N15/09; A61K38/00; A61P25/00; C07K1/14; C07K14/475; C07K14/74; C07K16/28; C12N5/00; C12N5/10; C12N15/02; C12P21/02; C12P21/08; C12R1/91; (IPC1-7): C07K14/74; A61K38/00; C07K1/14; C12N5/10; C12N15/02; C12N15/09; C12P21/02; C12P21/08
Attorney, Agent or Firm:
Kyozo Yuasa (6 people outside)