Title:
ヤケヒョウヒダニ由来の低アレルゲン性DerP1およびDerP3タンパク質
Document Type and Number:
Japanese Patent JP2007525150
Kind Code:
A
Abstract:
The present invention provides a novel treatment for allergy comprising the provision of a recombinant Der p 1/ProDer p 1/PreProDer p 1 allergen derivative, ProDer p 3 or a recombinant ProDer p 3/Der p 3/PreProDer p 3 allergen derivative with hypoallergenic activity. Pharmaceutical compositions comprising said mutant allergens which stimulate a Th1-type immune response in allergic or naïve individuals thereby reducing the potential for an allergic response upon contact with the wild-type allergen, are also provided.
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Inventors:
Jacket, alan
Application Number:
JP2006501950A
Publication Date:
September 06, 2007
Filing Date:
February 24, 2004
Export Citation:
Assignee:
GlaxoSmithKline Biologicals Society Anonymous
International Classes:
C12N15/09; A61K9/00; A61K31/7088; A61K38/00; A61K39/00; A61K39/35; A61K39/39; A61K48/00; A61P37/08; C07K14/435; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/48; C12N15/12; A61K9/19
Domestic Patent References:
| JP2001523452A | 2001-11-27 |
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Ishii Teiji
Satoshi Fujita