Title:
抗血栓作用を有するマロンアミド誘導体
Document Type and Number:
Japanese Patent JP2010532769
Kind Code:
A
Abstract:
The present invention relates to compounds of formula I, The compounds of formula I are valuable pharmacologically active compounds. They exhibit a strong anti-thrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardio-vascular disorders like thromboembolic diseases or restenoses. They are inhibitors of the blood clotting enzymes, especially factor VIIa and can in general be applied in conditions in which an undesired activity of factor VIIa is present or for the cure or prevention of which an inhibition of factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
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Inventors:
Henning Steinhagen
Haoke Shirato
Marx Forman
Reinhard Kirsch
Volkmar Weener
Hans Matter
Martin Lorenz
Kent Double Neuen Schwander
Anthony Sea Scotese
Haoke Shirato
Marx Forman
Reinhard Kirsch
Volkmar Weener
Hans Matter
Martin Lorenz
Kent Double Neuen Schwander
Anthony Sea Scotese
Application Number:
JP2010515374A
Publication Date:
October 14, 2010
Filing Date:
June 26, 2008
Export Citation:
Assignee:
Sanofi-Aventis
International Classes:
C07D207/12; A61K31/167; A61K31/337; A61K31/341; A61K31/351; A61K31/381; A61K31/40; A61K31/4025; A61K31/4164; A61K31/44; A61K31/4409; A61K31/4462; A61K31/4465; A61K31/4535; A61K31/495; A61K31/4965; A61K31/50; A61K31/5375; A61K31/5377; A61K31/553; A61P7/02; A61P9/00; A61P9/10; A61P11/00; A61P29/00; A61P31/04; A61P43/00; C07D207/263; C07D211/42; C07D211/44; C07D211/62; C07D213/30; C07D213/70; C07D213/80; C07D239/26; C07D241/18; C07D277/24; C07D277/28; C07D295/22; C07D305/06; C07D307/20; C07D307/42; C07D309/08; C07D309/10; C07D333/16; C07D333/28; C07D409/12
Attorney, Agent or Firm:
Junji Yuda
Noriyuki Takebayashi
Noriyuki Takebayashi