抗酸化活性物質の製造方法

Japanese Patent JP5464444

B2

Disclosed is a process for producing carnosic acid (the major antioxidant active substance contained in a rosemary plant) with high efficiency by carrying out the ortho-position oxidation of a phenol with an oxidizing agent (e.g., 2-iodoxybenzoic acid) and the subsequent ester removal reaction by using, as a starting material, pisiferic acid (the main component of Chamaecyparis pisifera which is a plant which has been planted in great numbers as wood resources). Specifically disclosed is a process for producing an antioxidant active substance contained in a rosemary plant and represented by general formula (5).  The process is characterized by comprising: a first step of oxidizing a pisiferic acid derivative represented by general formula (1) with an oxidizing agent represented by general formula (2) or (4); and a second step of reducing or hydrolyzing a pisiferic acid derivative intermediate produced in the first step.

JP4959041	Derivatives of dihydro or tetrahydronaphthalene and pharmaceutical compositions containing them
JP2829799	PROBLEM TO BE SOLVED: To produce isoamyl glycolic acid

Masahiro Tada

JP2010516861A

April 09, 2014

June 09, 2009

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National University Corporation Tokyo University of Agriculture and Technology

C07C51/367; C07C62/32; C07B53/00

JP2006199666A	2006-08-03
JP2007508320A	2007-04-05

JPN6013048842; Ｂｉｏｏｒｇａｎｉｃ　＆　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ　Ｌｅｔｔｅｒｓ , 2004, Ｖｏｌ．　１４
JPN6009043985; Ｗａｌｔｅｒ　Ｌ．　ＭＥＹＥＲ，　Ｒｉｃｈａｒｄ　Ａ．　ＭＡＮＮＩＮＧ，　Ｅｒｉｃｈ　ＳＣＨＩＮＤＬＥＲ，　Ｒｏｂｅｒｔ　Ｓ．　ＳＣＨＲＯＥＤＥＲ，　Ｄ．　Ｃｒａｉｇ　ＳＨＥＷ: 'Ｄｉｔｅｒｐｅｎｏｉｄ　Ｔｏｔａｌ　Ｓｙｎｔｈｅｓｉｓ，　ａｎ　Ａ->Ｂ->Ｃ　Ａｐｐｒｏａｃｈ．　ＶＩＩＩ．　Ｉｎｔｒｏｄｕｃｔｉｏｎ　ｏｆ　Ｏｘｙｇｅｎ　ａｔ　Ｃａｒｂｏｎ-１１．　Ｔｏｔａｌ　Ｓ' Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｏｒｇａｎｉｃ　Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．　４１，　Ｎｏ．　６, 1976, １００５-１０１５

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