To obtain the subject new compound useful as a chemokine receptor antagonist capable of inhibiting diseases caused by the chemokine such as interleukin 8 or MIP-1 α.
This compound is represented by the formula; R1-X1-ph-X2-A-Y- R2 [A is D or L-Arg, Lys or the like; X1 is NH, O or the like; X2 is absent, SO2 or the like; Y is S, O or the like; R1 and R2 are each a 12-30C straight-chain alkyl, cholesteryl or the like], e.g. 2-(isopropylcarbamoyl)-benzoyl-L-arginine-n- hexadecylamide. The compound is obtained by condensing, e.g. an N-terminal protected amino acid with a compound represented by the formula; R2-Y-H, then removing the N-terminal protecting group, condensing the resultant compound represented by the formula; A'-Y-R2 (A' is an amino acid having the protected side chain) with a compound represented by the formula; R1X1-ph-X2-Z (Z is a halogen or hydroxyl group) and prepared by condensing a compound represented by the formula; R1-X1-Z with a compound represented by the formula; X1-ph-X2-OR4 (R4 is a protecting group) and subsequently deprotecting the obtained compound and further removing the side chain protecting group of the amino acid.
HIROSE KUNITAKA
YANAKA MIKIRO
MARUOKA HIROSHI
HAKOZAKI MITSUNORI
YAMAZAKI TORU
DEWA TOSHIKAZU
TAKEMURA YOSHIYUKI
INOGUCHI EIJI
EDAMATSU TAKEO
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