CARBOHYDRATE CONJUGATES AS DELIVERY AGENTS FOR OLIGONUCLEOTIDES

Title:

CARBOHYDRATE CONJUGATES AS DELIVERY AGENTS FOR OLIGONUCLEOTIDES

Document Type and Number:

Japanese Patent JP2018029599

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To provide iRNA agents conjugated with at least one carbohydrate ligand.SOLUTION: An oligonucleotide contains one or more conjugate structure. The conjugate structure may be shown below (X is CO, NH, O or the like; Y is NH, O, S or the like; Z is C(O)NH, NHC(O) or the like; tether is -(CH2) n- or the like; linker is a cyclic carrier such as pyrrolidinyl; sugar may be galactose or N-acetylgalactosamine; n is an integer of 1-6; q is an integer of 0-10).SELECTED DRAWING: None

More Like This:

JP3917640	NUCLEIC ACID PROBE-IMMOBILIZED SUBSTRATE AND METHOD FOR DETECTING THE PRESENCE OF TARGET NUCLEIC ACID BY USING THE SAME
JP2005538734	Preservation of RNA and reverse transcriptase during automatic liquid treatment
JP5122713	Compositions and Methods for Identifying and Targeting Cancer Cells

Inventors:

MUTHIAH MANOHARAN
KALLANTHOTTATHIL G RAJEEV
NARAYANANNAIR K JAYAPRAKASH
MARTIN MAIER

Application Number:

JP2017179798A

Publication Date:

March 01, 2018

Filing Date:

September 20, 2017

Export Citation:

Click for automatic bibliography generation Help

Assignee:

ALNYLAM PHARMACEUTICALS INC

International Classes:

C12N15/09; A61K31/7088; A61K47/26; A61K47/61; A61P31/12; C12N15/113

Domestic Patent References:

JP6215284B2

2017-10-18

Foreign References:

WO2006020768A2	2006-02-23
WO2006078278A2	2006-07-27
WO2005116226A2	2005-12-08

Other References:

NATURE BIOTECHNOLOGY,2007VOL.25,NO.10,P.1149-1157, JPN6013038197, ISSN: 0003877204
JOURNAL OF MEDICINAL CHEMISTRY,2004,VOL.47,NO.23,P.5798-5808, JPN6013038199, ISSN: 0003877205
JOURNAL OF MEDICINAL CHEMISTRY,1999,VOL.42,NO.4,P.609-618, JPN6013038200, ISSN: 0003877206
BIOCONJUGATE CHEM.,2003,VOL.14,NO.1,P.239-246, JPN6013038202, ISSN: 0003877207

Attorney, Agent or Firm:

Hiroshi Higuchi

Previous Patent: How to deal with a mango

Next Patent: Cultivation normalization of corneal endothelial cells