OPTICAL WAVEGUIDE TYPE GLUCOSE SENSOR

Japanese Patent JP3730652

B2

PROBLEM TO BE SOLVED: To provide an optical waveguide type glucose sensor capable of analyzing a specimen, for example, an extremely small amount of glucose in body fluids, with high sensitivity and with high precision.
SOLUTION: The optical waveguide type glucose sensor is equipped with a substrate 1, a first optical guide layer 2 formed on the surface of the substrate, a pair of gratings 3 respectively formed on the surfaces in the vicinity of both end parts of the first optical guide layer 2, a second optical guide layer 4, of which the refractive index is not lower than that of the first optical guide layer 2, formed on the first optical guide layer 2 which is positioned between a pair of the gratings 3, the functional layer 8, which contains enzyme and a color forming reagent, formed on the second optical guide layer 4 and a protective film 5, of which the refractive index is not higher than that of the first optical guide layer 2, further formed on the first optical guide layer 2 including the gratings 3 so as to expose a functional layer 8.

Shinji Uchiyama
Ichiro Higashino
Hideo Eto
Miki Nagatomo

JP2004291455A

January 05, 2006

October 04, 2004

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Toshiba Corporation

G01N21/27; G01N21/78; C12M1/40; G02B6/122; (IPC1-7): G01N21/27; C12M1/40; G01N21/78; G02B6/122

JP9061346A
JP5332937A
JP11271217A
JP5142142A
JP2000146836A
JP2001183292A
JP272873A
JP6167443A
JP2001194298A

WO2000019203A1

Hidekazu Miyoshi
Iwa Saki Kokuni
Kawamata Sumio
Nakamura Tomoyuki
Masakazu Ito
Shunichi Takahashi
Toshio Takamatsu

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