PD-1, RECEPTOR OF B7-4 AND USE OF THE SAME - DANA FARBER CANCER INST INC

Title:

PD-1, RECEPTOR OF B7-4 AND USE OF THE SAME

Document Type and Number:

Japanese Patent JP2014040419

Kind Code:

A

Abstract:

To provide a method to modulate immune response.

PD-1 polypeptide is identified as a receptor to B7-4. B7-4 can inhibit the activation of an immunocyte when it is bound to an inhibitory receptor on the immunocyte. Therefore, modulation of immune response is induced by modulating costimulatory or inhibitory signal in the immunocyte by providing an agent which modulates PD-1, B7-4 and interaction between B7-4 and PD-1.

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Inventors:

WOOD CLIVE
FREEMANN GORDON J

Application Number:

JP2013172201A

Publication Date:

March 06, 2014

Filing Date:

August 22, 2013

Export Citation:

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Assignee:

DANA FARBER CANCER INST INC
GENETICS INST LLC

International Classes:

A61K45/00; G01N33/50; A61K38/00; A61K39/00; A61K39/395; A61K45/06; A61P1/16; A61P3/10; A61P9/00; A61P9/10; A61P15/06; A61P19/02; A61P21/04; A61P25/00; A61P25/28; A61P29/00; A61P31/06; A61P31/12; A61P31/16; A61P31/18; A61P31/20; A61P31/22; A61P33/06; A61P33/12; A61P35/00; A61P37/02; A61P37/04; A61P37/06; A61P37/08; A61P41/00; A61P43/00; C07K14/705; C07K16/28; C12N15/09; C12N15/12; C12Q1/02; G01N33/15; G01N33/566

Attorney, Agent or Firm:

Mitsuo Tanaka
Hiroshi Yamazaki
Kenji Tomita

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