Title:
医薬化合物群
Document Type and Number:
Japanese Patent JP4364944
Kind Code:
B2
Abstract:
The invention provides novel cryptophycin compounds which can be useful for disrupting the microtubulin system, as anti-neoplastic agents, and for the treatment of cancer. The invention further provides a formulation for administering the novel cryptophycin compounds.
More Like This:
| WO/2010/003084 | PHOSPHODIESTERASE 4 INHIBITORS |
| JPH0395179 | PREPARATION OF 4-ACRYLOXYAZETIDIN-2-ONE BY ELECTROCHEMICAL METHOD |
| WO1999019297 | SYNTHESIS OF AZETIDINE DERIVATIVES |
Inventors:
All-A-Hour, Lima Es
Ale Hart, William Jay
Gottmukkala, Sabaraj Buoy
Martinelli, Michael Jay
Mower, eric di
Moore, Richard Yee
Munroe, John Yee
Norman, Brian H
Patel, Vinod F
Sea, chuan
Toss, John Yee
Bus Devan, Benkatra Gabang
Ray, James E
Ale Hart, William Jay
Gottmukkala, Sabaraj Buoy
Martinelli, Michael Jay
Mower, eric di
Moore, Richard Yee
Munroe, John Yee
Norman, Brian H
Patel, Vinod F
Sea, chuan
Toss, John Yee
Bus Devan, Benkatra Gabang
Ray, James E
Application Number:
JP51195998A
Publication Date:
November 18, 2009
Filing Date:
August 29, 1997
Export Citation:
Assignee:
UNIVERSITY OF HAWAII
International Classes:
A61K31/395; C07D273/08; A61K31/427; A61K31/4427; A61K31/496; A61K31/7052; A61P35/00; A61P43/00; C07D273/00; C07D281/00; C07D291/02; C07D413/06; C07D413/10; C07D413/12; C07D417/06; C07D417/14; C07F9/12; C07F9/6527; C07H15/26; A61K31/4025; A61K31/4172
Foreign References:
| WO1995017093A1 |
Other References:
GOLAKOTI, T., et al., Structure Determination, Conformational Analysis, Chemical Stability Studies, and Antitumor Evaluation of the Cryptophycins. Isolation of 18 New Analogs from Nostoc sp. Strain GSV 224, Journal of the American Chemical Society, 1995年, 117(49), p. 12030-12049
REJ, R., et al., Total Synthesis of Cryptophycins and Their 16-(3-Phenylacryloyl) Derivatives, The Journal of Organic Chemistry, 1996年, 61, p. 6289-6295
TRIMURTULE, G., et al., Total Structures of Cryptophycins, Potent Antitumor Depsipeptides from the Blue-Green Alga Nostoc sp. Strain GSV 224, Journal of the American Chemical Society, 1994年, 116(11), p. 4729-4737
MOORE, RE, Cyclic peptides and depsipeptides from cyanobacteria: a review, Journal of Industrial Microbiology, 1996年, 16, p. 134-143
KOBAYASHI, M., et al., Improved total synthesis and structure-activity relationship of arenastatin A, a potent cytotoxic spongean depsipeptide, Chemical & pharmaceutical bulletin, 1995年, 43(9), p. 1598-1600
REJ, R., et al., Total Synthesis of Cryptophycins and Their 16-(3-Phenylacryloyl) Derivatives, The Journal of Organic Chemistry, 1996年, 61, p. 6289-6295
TRIMURTULE, G., et al., Total Structures of Cryptophycins, Potent Antitumor Depsipeptides from the Blue-Green Alga Nostoc sp. Strain GSV 224, Journal of the American Chemical Society, 1994年, 116(11), p. 4729-4737
MOORE, RE, Cyclic peptides and depsipeptides from cyanobacteria: a review, Journal of Industrial Microbiology, 1996年, 16, p. 134-143
KOBAYASHI, M., et al., Improved total synthesis and structure-activity relationship of arenastatin A, a potent cytotoxic spongean depsipeptide, Chemical & pharmaceutical bulletin, 1995年, 43(9), p. 1598-1600
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Youichi Inoue
Naganuma Akio
Hajime Asamura
Youichi Inoue
Naganuma Akio