Title:
PHENYLETHENYL OR PHENYLETHINYL DERIVATIVE AS GLUTAMATE RECEPTOR ANTAGONIST
Document Type and Number:
Japanese Patent JP2008169206
Kind Code:
A
Abstract:
To provide a novel glutamate receptor antagonist.
The present invention retates to the use of a compound represented by formula (I) [wherein R1, R2, R3, R4 and R5 each independently represent hydrogen, a lower alkyl, a -(CH2)n-halogen, a lower alkoxy, a -(CH2)n-NRR', a -(CH2)n-N(R)-C(O)-lower alkyl, an aryl or a heteroaryl which is not substituted or substituted with one or more lower alkyl residues, and A represents -CH=CH- or -CC-] or a pharmaceutically acceptable salt thereof for producing a pharmaceutical agent for treatment or prevention of mGluR5 receptor mediated disorders.
Inventors:
MUTEL VINCENT
PETERS JENS-UWE
WICHMANN JUERGEN
PETERS JENS-UWE
WICHMANN JUERGEN
Application Number:
JP2007325072A
Publication Date:
July 24, 2008
Filing Date:
December 17, 2007
Export Citation:
Assignee:
HOFFMANN LA ROCHE
International Classes:
A61K31/4045; C07D209/14; A61K31/415; C07D233/64; A61K31/4155; A61K31/4164; A61K31/4174; A61K31/4178; A61K31/4245; A61K31/437; A61K31/4985; A61K31/5383; A61K31/542; A61P1/08; A61P9/02; A61P9/10; A61P13/02; A61P19/08; A61P21/02; A61P21/04; A61P25/00; A61P25/04; A61P25/06; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P25/34; A61P25/36; A61P27/02; A61P31/18; A61P43/00; C07D209/16; C07D231/12; C07D233/54; C07D233/58; C07D233/68; C07D233/90; C07D233/92; C07D233/94; C07D403/06; C07D403/10; C07D413/04; C07D491/147; C07D495/14; C07D498/04; C07D513/14
Attorney, Agent or Firm:
Hajime Tsukuni
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