To obtain the subject new compound useful for curing and preventing diseases of coronary artery, protecting early atherosclerosis of coronary artery and curing cancers by increasing a high density lipoprotein level.
This restricted 9-cis retinoid is a compound expressed by formula I [A, B and C are each CH, CH2, O or S, wherein no more than one heteroatom is present; D is a residue of the formula; (CH)m [(m) is 0 or 1] or the formula; (CH2)n [(n) is 0-2]; R is H, methyl, ethyl, t-butyl or CF3; A is a residue expressed by formula II (R1 to R4 are each H, a 1-3C alkyl, a 1-3C alkoxy or CF3), a residue expressed by formula III (R is H, a 1-3C alkyl, methoxy or CF3; R6 is H, methyl or ethyl) or the like; Y is H or the like; X is CH2OH, CHO, CN, COOH or the like) or its salt or ester, e.g. Z, E and E,E-3- methyl-5-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-cyclohexen-1- yl]-2,4-pentadienoic acid ethyl ester.
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GEIRII HARORUDO BAANBAAGU
JIYOZEFU UIRIAMU EPUSUTAIN
ADAMU MASHIYUU GIRUBAATO
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