RXR HOMODIMER FORMATION, BRIDGED BICYCLIC AROMATIC COMPOUND, AND THEIR USE IN MODULATED GENE EXPRESSION

Japanese Patent JP2007001982

A

To provide a method for screening a substance for the ability to exert an influence on the formation of a retinoid X receptor homodimer comprising a step for combining the substance and a solution containing retinoid X receptors and a step for determining the presence of homodimer formation.

The method for screening a substance for the ability to exert an influence on the formation of a retinoid X receptor homodimer comprises a step to combine the substance and a solution containing retinoid X receptors and a step to determine the presence of homodimer formation, and includes a step to determine the presence of the homodimer formation by detecting the activation of transcription by the retinoid X receptor homodimer.

PHAHL MAGNUS
ZHANG XIAO-KUN
LEHMANN JURGEN M
DAWSON MARCIA I
CAMERON JAMES F
HOBBS PETER D
JONG LING

JP2006192124A

January 11, 2007

July 12, 2006

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LIGAND PHARM INC

C07C63/04; G01N33/50; A61K31/19; A61K31/192; A61K31/216; A61K31/335; A61K31/357; A61K31/36; A61K31/38; A61K31/381; A61K31/385; A61K31/39; A61P3/00; A61P3/02; A61P5/12; A61P17/00; A61P17/02; A61P17/06; A61P17/12; A61P19/00; A61P31/12; A61P35/00; A61P35/02; A61P37/00; A61P43/00; C07C63/49; C07C63/66; C07C65/36; C07C69/738; C07C69/76; C07C233/64; C07D311/58; C07D317/30; C07D319/04; C07D319/06; C07D327/04; C07D333/22; C07D333/38; C07D333/40; C07D339/06; C07D339/08; C07D409/04; C07K14/705; C12N15/09; C12Q1/02; C12Q1/68; G01N33/15; G01N33/53; G01N33/566; G01N33/68; G01N33/74

JPH08506323A	1996-07-09
JP2004159664A	2004-06-10

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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