Title:
置換された2-ナフトイルグアニジン、その製法、医薬または診断剤としてのその使用およびそれを含有する医薬
Document Type and Number:
Japanese Patent JP4039588
Kind Code:
B2
Abstract:
2-Naphthoyl-guanidines (I) and their salts are new: R1 and R3-R8 = H; F; Cl; Br; I; CN; NO2; CF3; C2F5; VpQqU; XYaWZ; or X'YaWZ' (at least 1 is XYaWZ or X'YaWZ'); V = O; S; SO; SO2; NR60; OCO; CO; CONR60; COO; or CR66R67; Q = 1-8C alkylene with 1 CH2 optionally replaced by O, S, NR13 or o-, m- or p-phenylene; U = H; 1-7C alkyl; 3-7C cycloalkyl; COR65; SO2R65; NR61R62; or Ph or a N- or C-linked N-containing 1-9C heterocycle optionally mono-, di- or trisubstituted by F, Cl, Br, CF3, Me, OMe or NR63R64; p, q = 0 or 1; X = O; S; NR10; or CR11R12; Y = 1-8C alkylene with 1 CH2 optionally replaced by O, S, NR13 or o-, m- or p-phenylene; W = CH2; SO2; S(O)(NH); or (when W is not attached directly to a hetero atom of XYa) O or NR14; Z = COR15; SO2R15; or (when W is not O or NR14) NR16R17; a = 0 or 1; X' = CO, CONR30, COO, SO, SO2, SO2NR30, OCO, NR30CO or NR30SO2 linked with the ring via the left hand atom; Z' = COR15; SO2R15; a N- or C-linked N-containing 1-9C heterocycle optionally mono-, di- or trisubstituted by F, Cl, Br, CF3, Me, OMe or NR21R22; or (when W is not O or NR14) Z' is NR16R17; R10-R12 = H; 1-6C alkyl; 1-4C perfluoroalkyl; or 3-7C cycloalkyl; R13, R14, R68 = H; 1-6C alkyl; 1-4C perfluoroalkyl; or 3-6C cycloalkyl; R15 = N=C(NH2)2; NR18R19; N(CH2)bNR18R19; or OR20; b = 2 or 3; R16 - R19 = H; 1-8C alkyl; or 1-4C perfluoroalkyl; or R16+R17 or R18+R19 = tetra- or pentamethylene with 1 CH2 optionally replaced by O, S or NA; A = H; Me; benzyl; or p-Cl-Ph; R20, R30; R60; R66; R67 = H; 1-6C alkyl; 1-4C perfluoroalkyl; or 3-7C cycloalkyl; R21, R22; R63, R64 = H; 1-4C alkyl; or 1-4C perfluoroalkyl; R65 = N=C(NH2)2; NR61R62; or OR60; R61, R62 = H; 1-8C alkyl; or 1-4C perfluoroalkyl; or R61+R62 = tetra- or pentamethylene with 1 CH2 optionally replaced by O, S or NA; provided that at least one of R5-R8 is not H.
Inventors:
Joachim Brendel
Heinz-Werner Kleman
Heinrich Kristien Arngrat
Hans Johen Lang
Yan-Robert Schievalk
Andreas Wueichert
Bansi Ral
Heinz-Werner Kleman
Heinrich Kristien Arngrat
Hans Johen Lang
Yan-Robert Schievalk
Andreas Wueichert
Bansi Ral
Application Number:
JP13822797A
Publication Date:
January 30, 2008
Filing Date:
May 28, 1997
Export Citation:
Assignee:
Hoechst Gesellschaft Mito Beschlenktel Haftung
International Classes:
C07C279/22; A01N1/02; C07D295/14; A01N47/44; A61K31/155; A61K31/165; A61K31/27; A61K31/44; A61K31/495; A61K31/535; A61K31/5375; A61P3/06; A61P3/10; A61P9/00; A61P9/06; A61P9/10; A61P35/00; A61P43/00; C07C271/22; C07C277/08; C07C279/20; C07C311/19; C07C317/50; C07C323/62; C07D213/40; C07D213/75; C07D295/08; C07D295/088
Domestic Patent References:
| JP8041028A | ||||
| JP8225513A | ||||
| JP9067332A | ||||
| JP8059598A |
Attorney, Agent or Firm:
Chika Takagi
Tatsuo Sato
Kosuke Nishimura
Tatsuo Sato
Kosuke Nishimura
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