Title:
【発明の名称】成長ホルモン分泌促進薬によるインスリン耐性の処置
Document Type and Number:
Japanese Patent JP2000514099
Kind Code:
A
Abstract:
This invention is directed to methods of treating insulin resistance in a mammal which comprise administering an effective amount of a compound of formula I,where the variables are defined in the specification, or the stereoisomeric mixtures, diastereomerically enriched, diastereomerically pure, enantiomerically enriched or enantiomerically pure isomers, or the pharmaceutically acceptable salts and prodrugs thereof to said mammal. The compounds of formula I are growth hormone secretagogues and as such are useful for increasing the level of endogenous growth hormone. In another aspect this invention provides certain intermediates which are useful in the synthesis of the foregoing compounds and certain processes useful for the synthesis of said intermediates and th compounds of formula I. This invention is further directed to methods comprising administering to a human or other animal a combination of a functional somatostatin antagonist such as an alpha-2 adrenergic agonist and a compound of formula I.
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Inventors:
Carpino, Philip Albert
Chu, Charles Wok-Hun
Lef Car, Bruce Allen
Bread, Lydia Codetta
Treadway, Judith Lee
The Wistski, Michael Paul
Chu, Charles Wok-Hun
Lef Car, Bruce Allen
Bread, Lydia Codetta
Treadway, Judith Lee
The Wistski, Michael Paul
Application Number:
JP50402999A
Publication Date:
October 24, 2000
Filing Date:
June 05, 1998
Export Citation:
Assignee:
Pfizer Products Inc.
International Classes:
A61K38/00; A61K38/05; A61K38/25; A61P3/04; A61P5/02; A61P9/04; A61P25/00; A61P25/20; A61P43/00; C07D211/60; C07D211/74; C07D211/78; C07D471/04; C07K1/02; C07K1/06; C07K5/04; C07K5/06; C07D; C07K; (IPC1-7): A61K38/00; A61P3/04; A61P5/02; A61P9/04; A61P25/20; A61P43/00; C07D211/74; C07D471/04; C07K5/06
Attorney, Agent or Firm:
Kazuo Shamoto (4 outside)