【発明の名称】脳血液関門を通して輸送されるカチオン化抗体 - The Regents of The University of California

Title:

【発明の名称】脳血液関門を通して輸送されるカチオン化抗体

Document Type and Number:

Japanese Patent JPH03500644

Kind Code:

A

Abstract:

The rate of trancytosis of antibodies across the blood-brain barrier is increased by cationizing the antibodies to provide cationized antibodies having an isoelectric point of between about 8.0 to 11.0. The increased rates of transport across the blood-brain barrier makes such cationized antibodies useful for both neurodiagnostic and neuropharmaceutical purposes. Methods for preparing such cationized antibodies are disclosed.

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Inventors:

Paddridge, William M
Simmel, Paul Earl

Application Number:

JP50741588A

Publication Date:

February 14, 1991

Filing Date:

August 15, 1988

Export Citation:

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Assignee:

The Regents of The University of California

International Classes:

A61K39/395; A61K49/00; C07K1/107; C07K14/00; C07K16/00; C07K16/18; G01N33/531; G01N33/569; G01N33/577; A61K38/00; (IPC1-7): A61K39/395; A61K49/00; C07K3/08; C07K15/14; G01N33/531; G01N33/569; G01N33/577

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