Title:
13,13a-DIHYDROBERBERINE DERIVATIVES, THEIR PHARMACEUTICAL COMPOSITION AND USE
Document Type and Number:
WIPO Patent Application WO/2008/040192
Kind Code:
A1
Abstract:
The present invention provides 13,13a-dihydroberberine derivatives as shown below,
their physiologically acceptable salts, use and pharmaceutical composition comprising
the said derivatives. The said 13,13a-dihydroberberine derivatives are glucose
sorbefacient to muscle cells and have medical effects for improving glucose-tolerance
and insulin-resistance, facilitating weight loss, relaxing fatty liver, etc,
approved by tests to integer animals. The said compounds of the present invention
can be used for treating diabetes mellitus, adiposity, fatty liver and their
complications caused by insulin resistance.
Inventors:
HU LIHONG (CN)
YE JIMING (AU)
LI JINGYA (CN)
JAMES DAVID E (AU)
DRAEGEN EDWARD W (AU)
ZHANG HANKUN (CN)
CHENG ZHE (CN)
YE JIMING (AU)
LI JINGYA (CN)
JAMES DAVID E (AU)
DRAEGEN EDWARD W (AU)
ZHANG HANKUN (CN)
CHENG ZHE (CN)
Application Number:
PCT/CN2007/002882
Publication Date:
April 10, 2008
Filing Date:
September 30, 2007
Export Citation:
Assignee:
SHANGHAI INSTITUE OF MATERIA M (CN)
LI JIA (CN)
HU LIHONG (CN)
YE JIMING (AU)
LI JINGYA (CN)
JAMES DAVID E (AU)
DRAEGEN EDWARD W (AU)
ZHANG HANKUN (CN)
CHENG ZHE (CN)
LI JIA (CN)
HU LIHONG (CN)
YE JIMING (AU)
LI JINGYA (CN)
JAMES DAVID E (AU)
DRAEGEN EDWARD W (AU)
ZHANG HANKUN (CN)
CHENG ZHE (CN)
International Classes:
C07D455/03; A61K31/4375; A61P3/04; A61P3/06; A61P3/10
Foreign References:
| CN1582930A | 2005-02-23 | |||
| CN1393264A | 2003-01-29 | |||
| CN1330650A | 2002-01-09 | |||
| CN1295573A | 2001-05-16 | |||
| CN1629160A | 2005-06-22 | |||
| JPH0995452A | 1997-04-08 | |||
| CN1582930A | 2005-02-23 |
Other References:
WEI J. ET AL.: "Clinical study on improvement of type II diabetes mellitus complicated with fatty liver treated by berberine", ZHONGXIYI JIEHE GANBIN ZAZHI, vol. 14, no. 6, 2004, pages 334 - 336, XP008105192
HONGYAN ZHENG; WEIREN XU, CHINESE HERBAL MEDICINE, vol. 35, 2004, pages 708 - 711
JUAN WANG, CHINA AND FOREIGN MEDICAL JOURNAL, vol. 2, no. 12, 2004, pages 65 - 66
"cell-membrane chromatography and alloxan-induced diabetic mice", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, 2006, pages 1380 - 1383
KLIP, A. ET AL., ENDOCRINOLOGY, vol. 130, 1992, pages 2535 - 2544
YAMAMOTO, N. ET AL., ANAL. BIO., vol. 351, 2006, pages 139 - 145
HONGYAN ZHENG; WEIREN XU, CHINESE HERBAL MEDICINE, vol. 35, 2004, pages 708 - 711
JUAN WANG, CHINA AND FOREIGN MEDICAL JOURNAL, vol. 2, no. 12, 2004, pages 65 - 66
"cell-membrane chromatography and alloxan-induced diabetic mice", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, 2006, pages 1380 - 1383
KLIP, A. ET AL., ENDOCRINOLOGY, vol. 130, 1992, pages 2535 - 2544
YAMAMOTO, N. ET AL., ANAL. BIO., vol. 351, 2006, pages 139 - 145
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (Block B KingSound International Center, 116 Zizhuyuan Road, Haidian District, Beijing 7, CN)
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