7-HYDROXY-4H-THIENO[3,2-B]PYRIDIN-5-ON DERIVATIVE AND USE THEREOF

Title:

7-HYDROXY-4H-THIENO[3,2-B]PYRIDIN-5-ON DERIVATIVE AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2020/055164

Kind Code:

A1

Abstract:

Provided in the present invention is the following compound effective in treating and preventing HIF-associated diseases including ischemia and hypoxia by regulating HIF and stabilizing HIF-α. In particular, the compound is effective in preventing and treating inflammatory bowel disease (IBD). The compound of the present invention is represented by chemical formula I, and in addition, provided are: a prodrug, a salt, and a solvate of the compound, and isomers thereof; a pharmaceutical composition comprising the same; and a preparation method thereof. [Chemical Formula 1] (In the formula, U, V, W, X, Y, R1, R2, and R5 are as defined in the description)

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Inventors:

HONG YONG RAE (KR)
CHO JOONG MYUNG (KR)

Application Number:

PCT/KR2019/011832

Publication Date:

March 19, 2020

Filing Date:

September 11, 2019

Export Citation:

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Assignee:

CRYSTALGENOMICS INC (KR)

International Classes:

C07D513/14; A61K31/4365; A61P1/00; A61P29/00

Domestic Patent References:

WO2008137060A1	2008-11-13
WO2009053799A1	2009-04-30
WO2012130322A1	2012-10-04
WO2011057892A1	2011-05-19

Foreign References:

KR20100045480A

2010-05-03

Attorney, Agent or Firm:

KIM, Aera (KR)

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